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Artimmune SAS

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Orleans, FR

About Artimmune SAS

ArtImmune is a contract research company which offers consulting and preclinical research services in immunology and inflammation. We have a long expertise on lung diseases, but not limited to this domain.

Our mission is to evaluate in vivo the effects of novel drug candidates in lung, skin and gut diseases: allergic asthma, chronic bronchitis, lung fibrosis, emphysema and acute respiratory distress syndrome, psoriasis, wound healing, atopic dermatitis, and inflammatory Bowel disease (IBD), Pseudomonas aeruginosa and influenza A virus infection.

ArtImmune has a strong expertise in preclinical investigations of lung functions in vivo including plethysmography, bronchoalveolar lavage, cytology, histology, immunohistochemistry, and analysis of biochemical, immunological and molecular parameters.

Selected Publications

  • Li et al, Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells. Cell Death Dis. 2017; 8(4).
  • Madouri et al, Protein kinase Cθ controls type 2 innate lymphoid cell and TH2 responses to house dust mite allergen. J Allergy Clin Immunol. 2017;139(5)
  • Mascarell L et al, The regulatory dendritic cell marker C1q is a potent inhibitor of allergic inflammation. Mucosal Immunol. 2017; 10(3):695-704
  • Cochez PM et al., AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model. Eur J Immunol. 2016; 46(6):1449-59.
  • Rabeony H et al., IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome. Eur J Immunol. 2015; 45(10):2847-57.

Our Services (41)


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Colitis Animal Models

Price on request

DSS-induced colitis in mice
TNBS-induced colitis in mice

Mouse

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Oncology Animal Models

Price on request
  • Local tumor growth: Subcutaneous implantation of syngeneic tumors.
  • Lung metastasis: Intravenous injection of B16 melanoma, Lewis lung or CT26 colon carcinoma.
  • Xenograft of human tumors into nude mice.


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Lung Inflammation Animal Models

Price on request

Intranasal administration of LPS in mice or rat.
Readouts:

  • Cell infiltration (BronchoAlveolar Lavage: neutrophils)
  • Cytokines and chemokines profil (IL-1b, IL-6, TNFa, KC (CXCL1)
  • MyeloPerOxydase activity: lung neutrophils
  • Lung function: Bronchoconstriction
  • Lung inflammation (histology: Hematoxylin eosin staining)


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Skin Inflammation Animal Models

Price on request

Scleroderma:

  • Dermal and systemic fibrosis induced by bleomycin in mice
    Psoriasis:
  • Imiquimod (IMQ) induced Psoriasis in mice
  • Atopic dermatitis induced by MC903 in mice


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Bacterial Infection Animal Models

Price on request
  • Pseudomonas aeruginosa infection in mice
    Read-outs: Lung weight; Lung CFU; Lung inflammation (HE) staining); Cytokines in lung homogenates: IL-1b, IL-6, TNF.
  • Escherichia coli induced urinary tract infection model in mice
    Read-outs: Body weight evolution; CFU in urine, bladder and kidney; Myeloperoxydase (MPO) level in bladder; Histological analysis; H&E staining of bladder.


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Liver Fibrosis Animal Models

Price on request

Intraperitoneal administration of CCL4 in mice.
Read-outs:

  • Weight, side effects
  • ALT, AST, bilirubin
  • Neutrophils, MyeloPerOxydase activity in liver
  • Cytokines profile (IL-1b, IL-6 and TGFb) and TIMP-1, KC
  • Lung inflammation (histology: HE and Red Sirius staining), Collagen assay, Fibronectin, a-SMA


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Atopic Dermatitis Animal Models

Price on request
  • Dermal and systemic fibrosis induced by bleomycin in mice


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Wound Healing Animal Models

Price on request

Wound healing in female mice after taking aseptic 4 mm diameter biopsy punches


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Histology and Pathology Services

Price on request
  • Fresh and frozen Full tissue processing
  • Conventional fixation, processing and paraffin blocs
  • Preparation of microscopic slides and staining
  • Macroscopic analysis
  • Staining (HE, PAS, Sirius red, TMB, Luxol blue, PAS)
  • Immunofuorescence
  • Immunohistochemistry


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Psoriasis Animal Models

Price on request
  • Imiquimod (IMQ) induced Psoriasis in mice
  • Atopic dermatitis induced by MC903 in mice


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Tobacco Smoke-Induced Disease Animal Models

Price on request
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Peritonitis Animal Models

Price on request
  • Zymosan induced in mice
  • LPS induced in mice


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Multiple Sclerosis Animal Models

Price on request
  • MOG induced in mice


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Viral Infection Animal Models

Price on request
  • Influenza A virus infection in mice (Read-outs: Weight loss; fever; Differential cell count; Lung weight; Viral load in lung tissue; Mortality; Histology; Cytokines and chemokines in BALF: IL-6, TNF , CCL5)
  • Dengue virus infection in mice (Read-outs: Plasma ALT and AST; Plasma cytokines levels (IL-1b , TNF, IL-6, IFNg , CCL17 and CXCL1); Blood for hematology; MyeloPerOxydase activity in liver and spleen)


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Pulmonary Disease Animal Models

Price on request
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IBS/IBD Animal Models

Irritable Bowel Syndrome/Disease Animal Models
Price on request
  • DSS induced colitis in mice
  • TNBS induced colitis in mice
    Read-outs:
  • Clinical score, body weight, gut length.
  • Inflammation: cell infiltration in the gut
  • Gut inflammation (histology)


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Pulmonary Fibrosis Animal Models

Price on request
  • Bleomycin induced in mice and rats
  • CCL4 induced in mice
  • Silica induced in mice


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Cytokine Storm Testing

Price on request
  • In vivo anti CD3e


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COPD Animal Models

Chronic Obstructive Pulmonary Disease Animal Models
Price on request
  • Cigarette smoke
  • Ozone
  • Elastase


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Asthma Animal Models

Price on request
  • House dust mite (HDM) induced in mice
  • OVA induced in mice
  • Papain induced in mice
  • Birch pollen induced in mice


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Knock-In Mouse Development

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Rheumatoid Arthritis Animal Models

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  • KBxN induced in mice
  • Collagen type II antigen


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Gastroenterology Animal Models

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Genetic Engineering

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Immunoassays

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Clinical Research

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Biology

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Inflammation Animal Models

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Clinical and Anatomic Pathology

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Dermatology Animal Models

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Animal Models of Disease

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Transgenic Animal Model Development

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Respiratory Disease Animal Models

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Hepatic Animal Models

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CNS/Neurology Animal Models

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Pharmacology & Toxicology

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Infectious Disease Animal Models

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Transgenic Mouse Services

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Clinical Laboratory Services

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Immunology Animal Models

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Animal Models and Studies

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