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Artimmune SAS

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Orleans, FR

About Artimmune SAS

ArtImmune is a contract research company which offers consulting and preclinical research services in immunology and inflammation. We have a long expertise on lung diseases, but not limited to this domain.

Our mission is to evaluate in vivo the effects of novel drug candidates in lung, skin and gut... Show more »

ArtImmune is a contract research company which offers consulting and preclinical research services in immunology and inflammation. We have a long expertise on lung diseases, but not limited to this domain.

Our mission is to evaluate in vivo the effects of novel drug candidates in lung, skin and gut diseases: allergic asthma, chronic bronchitis, lung fibrosis, emphysema and acute respiratory distress syndrome, psoriasis, wound healing, atopic dermatitis, and inflammatory Bowel disease (IBD), Pseudomonas aeruginosa and influenza A virus infection.

ArtImmune has a strong expertise in preclinical investigations of lung functions in vivo including plethysmography, bronchoalveolar lavage, cytology, histology, immunohistochemistry, and analysis of biochemical, immunological and molecular parameters.

Selected Publications

  • Li et al, Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells. Cell Death Dis. 2017; 8(4).
  • Madouri et al, Protein kinase Cθ controls type 2 innate lymphoid cell and TH2 responses to house dust mite allergen. J Allergy Clin Immunol. 2017;139(5)
  • Mascarell L et al, The regulatory dendritic cell marker C1q is a potent inhibitor of allergic inflammation. Mucosal Immunol. 2017; 10(3):695-704
  • Cochez PM et al., AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model. Eur J Immunol. 2016; 46(6):1449-59.
  • Rabeony H et al., IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome. Eur J Immunol. 2015; 45(10):2847-57.
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Our Services (41)


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Colitis Animal Models

Price on request

DSS-induced colitis in mice
TNBS-induced colitis in mice

DSS-induced colitis in mice
TNBS-induced colitis in mice

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Oncology Animal Models

Price on request
  • Local tumor growth: Subcutaneous implantation of syngeneic tumors.
  • Lung metastasis: Intravenous injection of B16 melanoma, Lewis lung or CT26 colon carcinoma.
  • Xenograft of human tumors into nude mice.
  • Local tumor growth: Subcutaneous implantation of syngeneic tumors.
  • Lung metastasis: Intravenous injection of B16 melanoma, Lewis lung or CT26 colon carcinoma.
  • Xenograft of human tumors into nude mice.
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Lung Inflammation Animal Models

Price on request

Intranasal administration of LPS in mice or rat.
Readouts:

  • Cell infiltration (BronchoAlveolar Lavage: neutrophils)
  • Cytokines and chemokines profil (IL-1b, IL-6, TNFa, KC (CXCL1)
  • MyeloPerOxydase activity: lung neutrophils
  • Lung function: Bronchoconstriction
  • Lung inflammation (histology: Hematoxylin eosin staining)

Intranasal administration of LPS in mice or rat.
Readouts:

  • Cell infiltration (BronchoAlveolar Lavage: neutrophils)
  • Cytokines and chemokines profil (IL-1b, IL-6, TNFa, KC (CXCL1)
  • MyeloPerOxydase activity: lung neutrophils
  • Lung function: Bronchoconstriction
  • Lung inflammation (histology: Hematoxylin eosin staining)
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Skin Inflammation Animal Models

Price on request

Scleroderma:

  • Dermal and systemic fibrosis induced by bleomycin in mice
    Psoriasis:
  • Imiquimod (IMQ) induced Psoriasis in mice
  • Atopic dermatitis induced by MC903 in mice

Scleroderma:

  • Dermal and systemic fibrosis induced by bleomycin in mice
    Psoriasis:
  • Imiquimod (IMQ) induced Psoriasis in mice
  • Atopic dermatitis induced by MC903 in mice
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Bacterial Infection Animal Models

Price on request
  • Pseudomonas aeruginosa infection in mice
    Read-outs: Lung weight; Lung CFU; Lung inflammation (HE) staining); Cytokines in lung homogenates: IL-1b, IL-6, TNF.
  • Escherichia coli induced urinary tract infection model in mice
    Read-outs: Body weight evolution; CFU in urine, bladder and kidney; Myeloperoxydase (MPO) level in bladder; Histological analysis; H&E staining of bladder.
  • Pseudomonas aeruginosa infection in mice
    Read-outs: Lung weight; Lung CFU; Lung inflammation (HE) staining); Cytokines in lung homogenates: IL-1b, IL-6, TNF.
  • Escherichia coli induced urinary tract infection model in mice
    Read-outs: Body weight evolution; CFU in urine, bladder and kidney; Myeloperoxydase (MPO) level in bladder; Histological analysis; H&E staining of bladder.
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Liver Fibrosis Animal Models

Price on request

Intraperitoneal administration of CCL4 in mice.
Read-outs:

  • Weight, side effects
  • ALT, AST, bilirubin
  • Neutrophils, MyeloPerOxydase activity in liver
  • Cytokines profile (IL-1b, IL-6 and TGFb) and TIMP-1, KC
  • Lung inflammation (histology: HE and Red Sirius staining), Collagen assay, Fibronectin, a-SMA

Intraperitoneal administration of CCL4 in mice.
Read-outs:

  • Weight, side effects
  • ALT, AST, bilirubin
  • Neutrophils, MyeloPerOxydase activity in liver
  • Cytokines profile (IL-1b, IL-6 and TGFb) and TIMP-1, KC
  • Lung inflammation (histology: HE and Red Sirius staining), Collagen assay, Fibronectin, a-SMA
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Atopic Dermatitis Animal Models

Price on request
  • Dermal and systemic fibrosis induced by bleomycin in mice
  • Dermal and systemic fibrosis induced by bleomycin in mice
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Wound Healing Animal Models

Price on request

Wound healing in female mice after taking aseptic 4 mm diameter biopsy punches

Wound healing in female mice after taking aseptic 4 mm diameter biopsy punches

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Histology and Pathology Services

Price on request
  • Fresh and frozen Full tissue processing
  • Conventional fixation, processing and paraffin blocs
  • Preparation of microscopic slides and staining
  • Macroscopic analysis
  • Staining (HE, PAS, Sirius red, TMB, Luxol blue, PAS)
  • Immunofuorescence
  • Immunohistochemistry
  • Fresh and frozen Full tissue processing
  • Conventional fixation, processing and paraffin blocs
  • Preparation of microscopic slides and staining
  • Macroscopic analysis
  • Staining (HE, PAS, Sirius red, TMB, Luxol blue, PAS)
  • Immunofuorescence
  • Immunohistochemistry
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Psoriasis Animal Models

Price on request
  • Imiquimod (IMQ) induced Psoriasis in mice
  • Atopic dermatitis induced by MC903 in mice
  • Imiquimod (IMQ) induced Psoriasis in mice
  • Atopic dermatitis induced by MC903 in mice
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Tobacco Smoke-Induced Disease Animal Models

Price on request
Request a quote for more information about this service.

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Peritonitis Animal Models

Price on request
  • Zymosan induced in mice
  • LPS induced in mice
  • Zymosan induced in mice
  • LPS induced in mice
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Multiple Sclerosis Animal Models

Price on request
  • MOG induced in mice
  • MOG induced in mice
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Viral Infection Animal Models

Price on request
  • Influenza A virus infection in mice (Read-outs: Weight loss; fever; Differential cell count; Lung weight; Viral load in lung tissue; Mortality; Histology; Cytokines and chemokines in BALF: IL-6, TNF , CCL5)
  • Dengue virus infection in mice (Read-outs: Plasma ALT and AST; Plasma cytokines levels (IL-1b , TNF, IL-6, IFNg , CCL17... Show more »
  • Influenza A virus infection in mice (Read-outs: Weight loss; fever; Differential cell count; Lung weight; Viral load in lung tissue; Mortality; Histology; Cytokines and chemokines in BALF: IL-6, TNF , CCL5)
  • Dengue virus infection in mice (Read-outs: Plasma ALT and AST; Plasma cytokines levels (IL-1b , TNF, IL-6, IFNg , CCL17 and CXCL1); Blood for hematology; MyeloPerOxydase activity in liver and spleen)
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Pulmonary Disease Animal Models

Price on request
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IBS/IBD Animal Models

Irritable Bowel Syndrome/Disease Animal Models
Price on request
  • DSS induced colitis in mice
  • TNBS induced colitis in mice
    Read-outs:
  • Clinical score, body weight, gut length.
  • Inflammation: cell infiltration in the gut
  • Gut inflammation (histology)
  • DSS induced colitis in mice
  • TNBS induced colitis in mice
    Read-outs:
  • Clinical score, body weight, gut length.
  • Inflammation: cell infiltration in the gut
  • Gut inflammation (histology)
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Pulmonary Fibrosis Animal Models

Price on request
  • Bleomycin induced in mice and rats
  • CCL4 induced in mice
  • Silica induced in mice
  • Bleomycin induced in mice and rats
  • CCL4 induced in mice
  • Silica induced in mice
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Cytokine Storm Testing

Price on request
  • In vivo anti CD3e
  • In vivo anti CD3e
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COPD Animal Models

Chronic Obstructive Pulmonary Disease Animal Models
Price on request
  • Cigarette smoke
  • Ozone
  • Elastase
  • Cigarette smoke
  • Ozone
  • Elastase
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Asthma Animal Models

Price on request
  • House dust mite (HDM) induced in mice
  • OVA induced in mice
  • Papain induced in mice
  • Birch pollen induced in mice
  • House dust mite (HDM) induced in mice
  • OVA induced in mice
  • Papain induced in mice
  • Birch pollen induced in mice
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Knock-In Mouse Development

Price on request
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Rheumatoid Arthritis Animal Models

Price on request
  • KBxN induced in mice
  • Collagen type II antigen
  • KBxN induced in mice
  • Collagen type II antigen
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Gastroenterology Animal Models

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Genetic Engineering

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Immunoassays

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Clinical Research

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Biology

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Inflammation Animal Models

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Clinical and Anatomic Pathology

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Dermatology Animal Models

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Animal Models of Disease

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Transgenic Animal Model Development

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Respiratory Disease Animal Models

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Hepatic Animal Models

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CNS/Neurology Animal Models

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Pharmacology & Toxicology

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Infectious Disease Animal Models

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Transgenic Mouse Services

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Clinical Laboratory Services

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Immunology Animal Models

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Animal Models and Studies

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Bruno Pouzet

Head of Business Development

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