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APS Pathology Services

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Minneapolis, Minnesota, US

About APS Pathology Services

Pathology is the gold standard for the evaluation of medical device performance and safety designed for high volume and rapid throughput to meet and exceed all of your tissue and device collection requirements. APS has extensive histopathology services for preclinical research studies. We also offer a full set... Show more »

Pathology is the gold standard for the evaluation of medical device performance and safety designed for high volume and rapid throughput to meet and exceed all of your tissue and device collection requirements. APS has extensive histopathology services for preclinical research studies. We also offer a full set of services for studies performed at outside labs, as well as pathologist consulting services conducted within a comfortable working environment.

The APS pathology department operates a fully equipped, 5,000 square foot, histopathology and SEM laboratory in the main facility. APS pathology lab is operated by board certified histotechnicians and has advanced equipment for the precise sectioning of all medical devices, using paraffin, plastic thin microtomy, plastic EXAKT ground sectioning, and SEM techniques.

Our dedicated necropsy labs feature down draft tables, as well as gravity and static pressure perfusion systems to ensure that, once harvested, organs are completely fixed prior to histoprocessing. APS pathology staff are also highly skilled at intricate dissections necessary for today's complex tissue treatments and device implants. We take tissue and device harvest seriously.

APS has both board certified veterinary pathologists and MD, PhD pathologists who oversee gross necropsies, interpret histopathology slides and write reports evaluating the safety of products. Our pathology services technicians possess college degrees, histotechnology board certifications and have many years of hands-on experience.

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Our Services (23)


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Histological Staining

Price on request
  • Hemotoxylin and Eosin
  • Verhoeff Van Gieson
  • Luxol Fast Blue
  • PTAH and Carstairs (fibrin or muscle striations)
  • Gram
  • Von Kossa
  • Masson's Trichrome
  • Gomori Trichrome
  • Masson's Elastic Trichrome
  • Gomori Elastic Trichrome
  • Goldner's Trichrome
  • Movat's Pentachrome
  • Hemotoxylin and Eosin
  • Verhoeff Van Gieson
  • Luxol Fast Blue
  • PTAH and Carstairs (fibrin or muscle striations)
  • Gram
  • Von Kossa
  • Masson's Trichrome
  • Gomori Trichrome
  • Masson's Elastic Trichrome
  • Gomori Elastic Trichrome
  • Goldner's Trichrome
  • Movat's Pentachrome
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Special Slide Staining

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Tissue Sectioning

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  • Microtomy
  • Cryosectioning
  • Plastic microtomy and EXAKT grinding
  • EXAKT grinding
  • Microtomy
  • Cryosectioning
  • Plastic microtomy and EXAKT grinding
  • EXAKT grinding
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Plastic Methyl Methacrylate Embedding

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Resin Embedding

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Paraffin Embedding

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Histomorphometric Analysis

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Scanning Electron Microscopy (SEM)

Scanning Electron Microscopy services
Price on request

American Preclinical Services has in-house, GLP compliant SEM capability, which can perform imaging on wet or dry specimens without the need for critical point drying or sputter coating.
SEM is useful for qualitatively evaluating cellular deposition and tissue-related effects on devices and implants (e.g. endothelialization,... Show more »

American Preclinical Services has in-house, GLP compliant SEM capability, which can perform imaging on wet or dry specimens without the need for critical point drying or sputter coating.
SEM is useful for qualitatively evaluating cellular deposition and tissue-related effects on devices and implants (e.g. endothelialization, fibrin deposition, granuloma formation), as well as surface changes (oxidation, pitting, cracking) and surface erosion.
All image acquisition is performed by our trained pathology technicians to ensure images of representative and abnormal nature are precisely acquired. In addition, APS is capable of splicing image montages, so you can view an entire surface or device as one large image, with minimal loss in resolution.

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Stereomicroscopy

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Animal Necropsy Services

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  • Large / Small Animal
  • Microdissection
  • In-situ perfusion fixation
  • Ex-vivo perfusion fixation
  • Fluorogram guided tissue harvesting
  • Pharmacokinetic sampling
  • TTC in-situ and ex-vivo staining
  • Evans blue staining
  • Large / Small Animal
  • Microdissection
  • In-situ perfusion fixation
  • Ex-vivo perfusion fixation
  • Fluorogram guided tissue harvesting
  • Pharmacokinetic sampling
  • TTC in-situ and ex-vivo staining
  • Evans blue staining
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Microscopy

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Tissue Embedding

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Imaging & Spectroscopy

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Discovery Pathology

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Optical Microscopy

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Biospecimens

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Tissue Processing

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Clinical Research

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Clinical Laboratory Services

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Cells and Tissues

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Fluorescence-Based Microscopy

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Biology

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Clinical and Anatomic Pathology

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