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Applied Pathology Systems

14 Orders Completed
Shrewsbury, Massachusetts, US

About Applied Pathology Systems

Applied Pathology Systems was founded in July 2016. We are dedicated to providing high quality histology services, accurate pathology evaluation, and superior human cancer specimens to help biotech and pharmaceutical companies fight against human diseases.

We are located in Biotechnology Park of University... Show more »

Applied Pathology Systems was founded in July 2016. We are dedicated to providing high quality histology services, accurate pathology evaluation, and superior human cancer specimens to help biotech and pharmaceutical companies fight against human diseases.

We are located in Biotechnology Park of University of Massachusetts Medical School, Worcester, Massachusetts. Our laboratory is staffed by experienced histologists and supervised by US board certified pathologists. The combination of our state-of-the-art histology laboratory and the strong histology and pathology expertise allows us to deliver high quality histology services and accurate data interpretation. On the other hand, we have developed a comprehensive list of clinical tissue specimens covering a wide range of cancer types with detailed annotated clinical data to further support related researches and development. We also welcome all types of collaborations and partnerships.

Publications

  • Liu J, Li H, et al. "Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid". Mol Pharmacol. 2003 May;63(5):983-92
  • Gutierrez S, Liu J. et al. "The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain". J Biol Chem. 2004 Oct 15;279(42):43581-8
  • McDonald ER 3rd, de Weck A, et al. "Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening" Cell. 2017 Jul 27;170(3):577-592
  • Leonard JL, Leonard DM, et al. "The Dkk3 gene encodes a vital intracellular regulator of cell proliferation". PLoS One. 2017 Sep 1;12(9)
  • Leo C, Yang X, et al. "Role of retinoid receptor coactivator pockets in cofactor recruitment and transcriptional regulation". J Biol Chem. 2001 Jun 22;276(25):23127-34
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Our Services (25)


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Histology and Pathology Services

Price on request

To support your research, APS offers a comprehensive list of services, including sample processing, embedding, sectioning, staining and imaging and pathologic evaluation, performed by our experienced histologists and a board certified pathologist. Customers also have the flexibility to request the specific needs during the... Show more »

To support your research, APS offers a comprehensive list of services, including sample processing, embedding, sectioning, staining and imaging and pathologic evaluation, performed by our experienced histologists and a board certified pathologist. Customers also have the flexibility to request the specific needs during the procedure. No matter what stage your samples are in, we can finish the rest.

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Human Rabbit Sheep Goat Mouse Pig Rat Dog Oncology Hematology Rare Disease CNS/Neurology Fibrotic Disease Dermatology Gastroenterology Respiratory Musculoskeletal/Orthopedic Hepatology Immuno-Oncology Inflammation Genetic Disease Neurology Gynecology Virology Metabolic Disease immunohistochemistry histology IHC H&E staining Special staining IF Paraffin Embedding in situ hybridization IF/ICC Histology assessment IHC Staining Pathology Review immunofluorescence labelling Pathology services pathology laboratory FFPE tissue Frozen Tissue Human tissue Bone marrow Brain Fresh Tissue Bone whole tissue Biology Drug Discovery Genomics Microbiology Pharmacology Neuroscience Show 54 more tags Show less

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H&E Staining

Hematoxylin and eosin staining
Price on request

Even though histology has been widely used in research and clinic for many years, it remains an essential technology that allows researchers and clinicians to study the morphology and structure of tissues in particular pathophysiological conditions. The Hematoxylin and Eosin (H&E) stain allows the visualization of nuclei and... Show more »

Even though histology has been widely used in research and clinic for many years, it remains an essential technology that allows researchers and clinicians to study the morphology and structure of tissues in particular pathophysiological conditions. The Hematoxylin and Eosin (H&E) stain allows the visualization of nuclei and cytoplasm respectively and is considered the general/ routine procedure in histology. Each step during the whole procedure may affect the H&E stain result dramatically.

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Human Rabbit Sheep Goat Mouse Pig Rat Dog Cat Regenerative Medicine Immunology Oncology Hematology CNS/Neurology Fibrotic Disease Dermatology Women's Health and Prenatal Care Gastroenterology Nephrology and Urology Pediatrics Metabolism and Endocrinology Otolaryngology/ENT Inflammation Neurology Virology Rheumatology H&E staining FFPE tissue Antibodies Frozen Tissue Human tissue Bone marrow Primary Cells Brain Fresh Tissue Bone Show 36 more tags Show less

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Special Slide Staining

Price on request

While the H&E stain is the general stain in histology that allows the pathologist to visualize most of the diseases or physiological conditions, special stains are used to differentiate some specific components that cannot be distinguished by H&E stain. Listed below are the more routinely performed special stains we offered at... Show more »

While the H&E stain is the general stain in histology that allows the pathologist to visualize most of the diseases or physiological conditions, special stains are used to differentiate some specific components that cannot be distinguished by H&E stain. Listed below are the more routinely performed special stains we offered at APS. If your special stains are not listed, we can also order any special staining kit and perform the stains for you.

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Human Rabbit Sheep Goat Mouse Rat Dog Cat Oncology Hematology Dermatology Women's Health and Prenatal Care Gastroenterology Respiratory Nephrology and Urology Otolaryngology/ENT Immuno-Oncology Inflammation Neurology Gynecology Metabolic Disease Rheumatology Special staining Masson's Trichrome Pathology services Show 25 more tags Show less

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Tissue Microarrays

Price on request

TMA allows researchers to investigate multiple cases of tissue in one slide, therefore increase the efficiency and consistency. TMAs can be used in many applications, such as immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH). In addition to our pre-made TMAs covering many types of cancers, we also offer... Show more »

TMA allows researchers to investigate multiple cases of tissue in one slide, therefore increase the efficiency and consistency. TMAs can be used in many applications, such as immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH). In addition to our pre-made TMAs covering many types of cancers, we also offer customized TMA construction with very flexible templates and features that you can choose from.

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Immunohistochemistry (IHC)

Price on request

In Immunohistochemistry (IHC), antibody can bind specifically to its antigen in biological tissues. IHC is a powerful tool to study the expression, localization, and distribution of a specific protein in the cells of a tissue section. Since the specific expression of some proteins is the characteristic of a particular disease or... Show more »

In Immunohistochemistry (IHC), antibody can bind specifically to its antigen in biological tissues. IHC is a powerful tool to study the expression, localization, and distribution of a specific protein in the cells of a tissue section. Since the specific expression of some proteins is the characteristic of a particular disease or cellular event, IHC staining has been widely used in both clinical diagnosis and basic researches, such as in pathway studies and biomarker development. However some of the procedures in IHC staining such as sample preparation and antigen retrieval could be very challenging and often need to be optimized. While in partnership with a third party company, we have validated a list of antibodies of some common targets for IHC staining. Our experienced histologists can also help to work up any antibody of your choice, and provide you the final IHC results.

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DAKO Autostainer Plus Immunology Oncology Hematology Rare Disease Fibrotic Disease Aging Dermatology Women's Health and Prenatal Care Gastroenterology Respiratory Nephrology and Urology Hepatology Nutrition Inflammation Genetic Disease Neurology Gynecology Virology Autoimmunity Metabolic Disease Rheumatology immunohistochemistry IHC IF IF/ICC IHC Staining immunofluorescence labelling Show 28 more tags Show less

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Pathology Reports

Price on request

Our contracted board certified pathologists could provide pathology report to precisely evaluate the pathological changes for particular specimens. We could evaluate both inflammation and neoplasm with either descriptive report or semi-quantitative report. Please tell us your requirement and we are also happy to discuss with you for the parameters/indexes for particular samples.

Our contracted board certified pathologists could provide pathology report to precisely evaluate the pathological changes for particular specimens. We could evaluate both inflammation and neoplasm with either descriptive report or semi-quantitative report. Please tell us your requirement and we are also happy to discuss with you for the parameters/indexes for particular samples.

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Human Biobanking

Starting at $40.00 per slide

We have a list of human cancer specimen covering most of the common cancers. These samples have detailed annotated clinical data to support your research. Please contact us for what you need.

We have a list of human cancer specimen covering most of the common cancers. These samples have detailed annotated clinical data to support your research. Please contact us for what you need.

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Common Histochemical Stains

Price on request

While the H&E stain is the general stain in histology that allows the pathologist to visualize most of the diseases or physiological conditions, special stains are used to differentiate some specific components that cannot be distinguished by H&E stain. In addition to H&E stain, listed below are the more routinely performed... Show more »

While the H&E stain is the general stain in histology that allows the pathologist to visualize most of the diseases or physiological conditions, special stains are used to differentiate some specific components that cannot be distinguished by H&E stain. In addition to H&E stain, listed below are the more routinely performed special stains we offered at APS. If your special stains are not listed, we can also order any special staining kit and perform the stains for you. PAS, Trichrome, Elastic, Sirius Red, Oil red O, Alcian Blue

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Biospecimens

Starting at $40.00 per slide

We have a list of human cancer specimen covering most of the common cancers. These samples have detailed annotated clinical data to support your research. Please contact us for what you need

We have a list of human cancer specimen covering most of the common cancers. These samples have detailed annotated clinical data to support your research. Please contact us for what you need

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Microscopy

Starting at $15.00 per slide

In addition to our whole slide scanning system that is mainly used to scan whole slides, our Olympus DP26 imaging system allows us to provide high quality of microscopic imaging. The price listed here is for two magnification of a representative view.

In addition to our whole slide scanning system that is mainly used to scan whole slides, our Olympus DP26 imaging system allows us to provide high quality of microscopic imaging. The price listed here is for two magnification of a representative view.

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Histological Staining

Price on request

While the H&E stain is the general stain in histology that allows the pathologist to visualize most of the diseases or physiological conditions, special stains are used to differentiate some specific components that cannot be distinguished by H&E stain. In addition to H&E stain, listed below are the more routinely performed... Show more »

While the H&E stain is the general stain in histology that allows the pathologist to visualize most of the diseases or physiological conditions, special stains are used to differentiate some specific components that cannot be distinguished by H&E stain. In addition to H&E stain, listed below are the more routinely performed special stains we offered at APS. If your special stains are not listed, we can also order any special staining kit and perform the stains for you. PAS, Trichrome, Elastic, Sirius Red, Oil red O, Alcian Blue

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immunohistochemistry in situ hybridization (ISH) immunofluorescence labelling

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Immunostaining

Price on request

We routinely perform immunostaining including IHC and IF for both cultured cells and FFPE or frozen sectioned slides. You could provide primary antibodies for the stain. We also have a list of validated antibodies that could be used directly to speed up your projects.

We routinely perform immunostaining including IHC and IF for both cultured cells and FFPE or frozen sectioned slides. You could provide primary antibodies for the stain. We also have a list of validated antibodies that could be used directly to speed up your projects.

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Cells and Tissues

Price on request

We could help to culture, treat and expand your cells. For tissue, we offer microdissection to isolated specific type of cells from your slides. Please contact us for detail.

We could help to culture, treat and expand your cells. For tissue, we offer microdissection to isolated specific type of cells from your slides. Please contact us for detail.

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Coverslipping

Starting at $0.50 per slide

As part of our histology service, we offer automatic coverslipping to slides you have (only for tissue/cell slides with standard size)

As part of our histology service, we offer automatic coverslipping to slides you have (only for tissue/cell slides with standard size)

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Histology Control Slides

Starting at $20.00 per slide

We offer extensive list of human control tissue slides. These tissues have been properly processed and preserved and have been using in our daily stains. Please contact us to see whether we have what you need.

We offer extensive list of human control tissue slides. These tissues have been properly processed and preserved and have been using in our daily stains. Please contact us to see whether we have what you need.

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Human Mouse Rat Oncology Hematology CNS/Neurology Immuno-Oncology Gynecology FFPE tissue Show 9 more tags Show less

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Immunofluorescence

Price on request

We offer both immunofluorescence (IF) staining and imaging, including microscopic imaging and whole slide scanning (both with three channels)

We offer both immunofluorescence (IF) staining and imaging, including microscopic imaging and whole slide scanning (both with three channels)

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Histopathological Examination

Price on request

Our contracted board certified pathologists could provide microscopic examination to precisely evaluate the histopathological changes for particular specimens. We could evaluate both inflammation and neoplasm with either descriptive report or semi-quantitative report. Please tell us your requirement and we are also happy to discuss with you for the parameters/indexes for particular samples

Our contracted board certified pathologists could provide microscopic examination to precisely evaluate the histopathological changes for particular specimens. We could evaluate both inflammation and neoplasm with either descriptive report or semi-quantitative report. Please tell us your requirement and we are also happy to discuss with you for the parameters/indexes for particular samples

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Immunocytochemistry

Price on request

APS scientists have developed a series of method to embed cultured cells and small amount of tissues into paraffin blocks for further study.

APS scientists have developed a series of method to embed cultured cells and small amount of tissues into paraffin blocks for further study.

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Whole Slide Imaging/Digital Slide Scanning

Starting at $15.00 per slide

In addition to taking digital images using our state-of-the-art digital imaging systems, we can also scan your entire slides and send you the whole images through a secured cloud. This will allow you to review, analyze, edit, and present your images in your own computer and share the images between your coworkers.

*Highlights... Show more »

In addition to taking digital images using our state-of-the-art digital imaging systems, we can also scan your entire slides and send you the whole images through a secured cloud. This will allow you to review, analyze, edit, and present your images in your own computer and share the images between your coworkers.

Highlights of whole slide scanning:

  • Access all the views of a slide from your computer
  • Keep permanent electronic files for important slides
  • Convenient to download, share your images through a secure network
  • High resolution scan up to 40X magnification
  • Free software that allows you to view slides at different magnifications, adjust the colors and snapshot your selected views for presentation.
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Mallory's Trichrome Staining

Price on request
Request a quote for more information about this service.

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Masson's Trichrome Staining

Price on request
Request a quote for more information about this service.

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Periodic Acid-Schiff (PAS) Staining

Price on request
Request a quote for more information about this service.

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Wiegert Elastic Fiber Staining

Price on request
Request a quote for more information about this service.

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Antibody Condition Optimization

Price on request
Request a quote for more information about this service.
Human Hamster Guinea pig Mouse Rat Immunology Oncology Hematology Rare Disease CNS/Neurology Fibrotic Disease Women's Health and Prenatal Care Infectious Disease Respiratory Hepatology Otolaryngology/ENT Immuno-Oncology Inflammation Genetic Disease Neurology Metabolic Disease immunohistochemistry IHC Fluorescent insitu hybridization immunofluorescence labelling Biology Drug Discovery Antibiotic Development Genomics Toxicology Neuroscience Epigenetics Show 32 more tags Show less

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Tissue Processing

Starting at $5.00 per sample

While we provide a full list of histology/pathology service, you also have the flexibility to request any steps during the process, including tissue dissecting, processing, embedding, sectioning, staining, imaging, and evaluation.

While we provide a full list of histology/pathology service, you also have the flexibility to request any steps during the process, including tissue dissecting, processing, embedding, sectioning, staining, imaging, and evaluation.

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LEICA TP300 Processor Human Mouse Rat Immunology Oncology Hematology Rare Disease Dermatology Gastroenterology Infectious Disease Respiratory Nephrology and Urology Metabolism and Endocrinology Musculoskeletal/Orthopedic Immuno-Oncology Inflammation Neurology Gynecology Autoimmunity Rheumatology tissue clearing Biology Drug Discovery Antibiotic Development Genomics Microbiology Pharmacology Neuroscience Show 29 more tags Show less

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James Liu

President
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Bryan Pursell

Lab Manager

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