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Antibody Solutions

17 Orders Completed
Sunnyvale, California, US

About Antibody Solutions

Antibody Solutions’ Mission is to provide the highest quality antibody services and products to meet meet our clients’ needs and applications.

Contract R & D is our Primary Focus. We offer a comprehensive portfolio of antibody services and products from antigen design through immunoassay and bioassay... Show more »

Antibody Solutions’ Mission is to provide the highest quality antibody services and products to meet meet our clients’ needs and applications.

Contract R & D is our Primary Focus. We offer a comprehensive portfolio of antibody services and products from antigen design through immunoassay and bioassay development.

All services are performed in the USA to maintain confidentiality of intellectual property and control of client materials.

Personalized service, breadth and depth of knowledge, and record of success combine to deliver superior results in a cost effective and timely manner.

Founded in 1995, Antibody Solutions is a privately held California Corporation serving customers around the world. Antibody Solutions is a member of BIO, the Biotechnology Industry Organization.

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Diversity Certificates

Small business

Our Services (29)


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Antibody Discovery

Price on request

Custom Antibody Discovery to meet your needs - From Therapeutic targets to Critical Reagents.

In as little as 10 weeks, Antibody Solutions can deliver your custom Antibody.
We have over 21 years of experience to rely on in developing your fit-for-purpose antibody.

Some of the variables we will examine when considering... Show more »

Custom Antibody Discovery to meet your needs - From Therapeutic targets to Critical Reagents.

In as little as 10 weeks, Antibody Solutions can deliver your custom Antibody.
We have over 21 years of experience to rely on in developing your fit-for-purpose antibody.

Some of the variables we will examine when considering your target and applications:
Animals: Multiple Species, Multiple Strains available. Including knock-out, auto-immune, and Transgenic Animals.
Antibody Solutions has extensive experience with OmniAb, Harbour, and Trianni Transgenic Animals.
Protocols: Multiple proven protocols examine the adjuvant, routes, and timing in order increase the chance of
producing the needed antibody.

Our Platform: Antibody Solutions specialized in hybridoma generation using our Hybridoma Library™ method. This method is essentially a bulk fusion used to immortalize the immune response of the animal. From there, we single cell sort the Hybridoma Library using Flow Cytometry, for true monoclonal results. Clones are tested (ELISA, High-Throughput Flow Cytometry, and others available) against your target and positive clones are expanded and cryopreserved.

Downstream Services Available!

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BD FACSAria Cell Sorting System AKTA FPLC Guava EasyCyte HT Perkin Elmer Enspire Rabbit Goat Chicken Mouse Rat Automated hybridoma Biofluids Drug Discovery Show 13 more tags Show less

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Monoclonal Antibody (mAb) Development

Price on request

We are the leading CRO for Monoclonal Antibody Development using conventional mice and rats, and human antibodies from transgenic animals (OmniAb, Harbour, Trianni).

Many features of our antibody development process make Antibody Solutions the obvious choice for your antibody development parter. Transgenic, hyperimmune, gene... Show more »

We are the leading CRO for Monoclonal Antibody Development using conventional mice and rats, and human antibodies from transgenic animals (OmniAb, Harbour, Trianni).

Many features of our antibody development process make Antibody Solutions the obvious choice for your antibody development parter. Transgenic, hyperimmune, gene knockout, and human antibody transgenic mice or rats may be used with a wide variety of antigens. Rapid (4-week) immunization protocols yielding high-affinity antibodies are available. Hybridoma Libraries can be interrogated for antibody binding activity prior to cloning. Our process include cloning of single-cells by flow cytometry which enables the analysis of true clones and does not require multiple round of sub-cloning. We offer ELISA, FIA, flow cytometry, and functional assays of antibody activity as well as label-free affinity and epitope analysis.

Benefits:

  • PEG fusion to enhance for Ab-secreting Hybridomas
  • HAT Selection of the Bulk Culture eliminates unstable hybridomas
  • Our Proprietary Cloning/Growth Factor ensures outgrowth of productive hybridomas
  • A cryopreserved a Cell Bank immortalizes the hybridoma population
  • Supernatant can be tested for antibody binding activity prior to cloning

Advantages over Structural Libraries:

  • Inducible system that can be driven to high sensitivity and specificity.
  • In vivo affinity maturation in multiple species.
  • Negative selection for self-Ag binding.
  • Natural pairing of heavy and light chains.
  • Ab secreted directly by the hybridoma, no cloning for expression.
  • Mammalian post-translational modification of Ab.
  • Fewer potential downstream issues.

Our Platform Advantages:

  • Hyperimmune and gene knockout mice
  • Human Transgenic Animals (OmniAb, Harbour, Trianni)
  • Rapid (4-week) immunization protocols
  • Optimized hybridoma culture conditions
  • Single-cell flow cloning (no sub-cloning required)
  • High-throughput flow screening
  • High-affinity clones in as little as 10 weeks
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Monoclonal Antibody (mAb) Production

Price on request

Reliable, Timely and Cost Effective Monoclonal Antibody Production and Purification Programs

MAbExpress™

The use of MAbExpress™ technology allows for reliable, timely and cost-effective antibody production and purification programs. This technology is the fastest way to obtain from 5 mg to grams of monoclonal antibody, and... Show more »

Reliable, Timely and Cost Effective Monoclonal Antibody Production and Purification Programs

MAbExpress™

The use of MAbExpress™ technology allows for reliable, timely and cost-effective antibody production and purification programs. This technology is the fastest way to obtain from 5 mg to grams of monoclonal antibody, and production and purification for all antibody species (mouse, rat, human) and isotopes (IgG and IgM). The in vitro methods utilized through MAbExpress™ that are animal friendly, in addition to being faster and producing more reliable results.

Standard MAb Express™ Production and Purification Programs

  • MAbExpress-5 mg:
    • Raw or purified antibody in as little as 14 days
    • Research-scale quantity of antibody –> Fast.
  • MAbExpress: 100 mg, 500 mg and >1 gram:
    • Manufacture-scale quantities of antibody
    • Quantities can be guaranteed by in-process monitoring
  • <0.01 EU/mg Endotoxin
  • <0.1% Bovine IgG
  • Very Low Protease, Host DNA & RNAse
  • High-Purity Abs for In Vivo Animal Studies
  • Analysis and documentation including Certificate of Analysis

Small Scale Pilot Productions also available. Please inquire for more information about these.

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Wheaton CellLine Bioreactor Human Mouse Rat in vitro

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Polyclonal Antibody Production

Price on request

A diverse and time-tested custom polyclonal antibody program makes Antibody Solutions a one-stop shop for serum production, affinity purification, and analysis. Available services include:

  • Anti-Idiotype Antibody Controls for Immunogenicity Assays
  • Affinity Purified Antibodies with Positive and Negative Selection
  • Rapid... Show more »

A diverse and time-tested custom polyclonal antibody program makes Antibody Solutions a one-stop shop for serum production, affinity purification, and analysis. Available services include:

  • Anti-Idiotype Antibody Controls for Immunogenicity Assays
  • Affinity Purified Antibodies with Positive and Negative Selection
  • Rapid Rabbit program (35 days) for high titer sera and high yields of affinity purified antibody.
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Antigen Design

Price on request

The Antigen Development services offered by Antibody Solutions are applicable to a wide range of applications and assays. Antibody Solutions has a long history of designing the appropriate antigen to generate antibodies with the affinity and specificity you need. We customize our antigen development to your specific needs. After... Show more »

The Antigen Development services offered by Antibody Solutions are applicable to a wide range of applications and assays. Antibody Solutions has a long history of designing the appropriate antigen to generate antibodies with the affinity and specificity you need. We customize our antigen development to your specific needs. After doing a target analysis, Antibody Solutions can suggest antigens based on the Customers specific objectives. Antibody Solutions can make or source your antigen, as appropriate.

Antibody Solutions has experience with:
Peptides and conjugates
Extracellular Domains
Human Cells
DNA
Syngeneic Transfectants
Viral Lipoparticles/VLPs
Nanodiscs
Haptens and Conjugates

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Cell Banking

Price on request

Antibody Solutions offers multi-tiered system of cell banks including Research, Master and Working Cell Banks. It is ideal for start-up groups for whom limited space and resources make on-site cell storage difficult, or larger organizations looking for a secure back-up site. Our cell banking service is a natural outgrowth of cell... Show more »

Antibody Solutions offers multi-tiered system of cell banks including Research, Master and Working Cell Banks. It is ideal for start-up groups for whom limited space and resources make on-site cell storage difficult, or larger organizations looking for a secure back-up site. Our cell banking service is a natural outgrowth of cell line development and testing services which we already provide.

We offer the a variety of services for cell banking including:

  • Cell expansion and cryopreservation
  • Testing
  • Storage
  • Clonality Testing
  • Patent deposits
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Analytical Method Development

Price on request

Robust, sensitive, reliable, and reproducible analytical methods are key to determining the physico-chemical and functional properties of antibodies.

Antibody Solutions offers analytical methods development including:

  • Critical Reagent Manufacture
  • Method Development
  • Method Qualification
  • Method Validation

Our... Show more »

Robust, sensitive, reliable, and reproducible analytical methods are key to determining the physico-chemical and functional properties of antibodies.

Antibody Solutions offers analytical methods development including:

  • Critical Reagent Manufacture
  • Method Development
  • Method Qualification
  • Method Validation

Our analytical method development optimizes and documents:

  • Repeatability (CV)
  • Intermediate precision (CV)
  • Accuracy (spike and recover for 70-130% potency samples is >90%)
  • Specificity (placebo has no activity even at 100 times concentration)
  • Additional experiments
  • Specificity
  • Stability indicating property
  • Location effects
  • Robustness

Contact us for tailor-made solutions to your analytical method development needs.

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Biolayer Interferometry

Price on request

We use Bio-layer Interferometry, a label-free technology for measuring biomolecular interactions at an optical surface, to measures molecular binding events. It is ideal to rank antibodies by binding kinetics, to determine epitope specificity of a collection of antibodies, and measure receptor-ligand interactions.

*Rank... Show more »

We use Bio-layer Interferometry, a label-free technology for measuring biomolecular interactions at an optical surface, to measures molecular binding events. It is ideal to rank antibodies by binding kinetics, to determine epitope specificity of a collection of antibodies, and measure receptor-ligand interactions.

Rank Antibodies by Binding Kinetics

  • Label-Free Kinetics Analysis
  • Affinity Measurement
  • Epitope Mapping
  • Pairing of Antibodies
  • Ligand Binding
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Assay Development

Price on request

Antibody Solutions offers custom-tailored method development for most bio-analytical assays used in pharmaceutical and diagnostics research and development. In our assay development we focus on antibody-driven solutions that are innovative, inexpensive, reliable, and amenable to high-throughput screening. We can also validate your... Show more »

Antibody Solutions offers custom-tailored method development for most bio-analytical assays used in pharmaceutical and diagnostics research and development. In our assay development we focus on antibody-driven solutions that are innovative, inexpensive, reliable, and amenable to high-throughput screening. We can also validate your and our assays for use under GLP and GMP regulations. Bioassays and immunoassays are among the many varieties of specialized biochemical assays we offer. We have developed assays to measure processes such as enzyme activity, antigen capture, cell proliferation and activities and competitive protein binding. We can offer services for the following assay types:

  • Bioanalytical Ligand Binding
  • ELISA
  • Flow Cytometry
  • Immunogenicity / HAHA
  • Immunohistochemistry
  • Itopia
  • PK/PD
  • Potency Assays
  • Western Blot
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Biochemistry & Molecular Biology

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Chemistry and Materials

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Cells and Tissues

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Recombinant Antibody Production

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Hybridoma Subcloning

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Recombinant Antigen Development

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Bioconjugation/Chemical Crosslinking

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Antibody Solutions offers custom conjugation of your peptide, antibody or other protein to haptens, carriers, labels and effector enzymes.

Antibody Solutions offers custom conjugation of your peptide, antibody or other protein to haptens, carriers, labels and effector enzymes.

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Project Management

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Animal Immunization for Antibody Production

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Interferometry

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Antigen Expression and Purification

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Antibody Isotyping

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Antibody Purification

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Therapeutic Monoclonal Antibody (mAb) Development

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Biology

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Imaging & Spectroscopy

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Antibody Services

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Analytical Chemistry Services

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Protein Services

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Epitope Mapping

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FileType/PDF Created with Sketch. Antibodies to Difficult Membrane Proteins.pdf

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FileType/PDF Created with Sketch. Critical Reagent (PK_ADA) Ab Discovery.pdf

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FileType/PDF Created with Sketch. General Overview.pdf

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FileType/PDF Created with Sketch. How We Work.pdf

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FileType/PDF Created with Sketch. Therapeutic Antibody Discovery Programs 2018.pdf

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