The Small Animal Core Facility provides Loyola University and outside researchers, including industry scientists, with a central resource for creating and studying cardiovascular physiology and pathophysiology in animal models on a fee-for-service basis.
While the central focus of the facility is cardiovascular research, the techniques employed are useful to a number of investigators in other fields. Currently, the facility is conducting studies focusing on burn and shock trauma, gene targeting, heart failure and other cardiovascular diseases. In addition to studying disease, the core can also provide laboratory teaching for various surgical techniques and echocardiography.
Services are oriented towards providing investigators with data suitable for use in grant proposals and manuscripts. Researchers work with the core facility scientists to assess their needs and provide the appropriate level of technical and scientific assistance.
cardio (2-D B mode short and long axis, m-mode, doppler flow) $100 animal
cardio (tissue doppler) add $30 animal
cardio (strain) add $30 animal
cardio (simpson’s) add $30 animal
cardio (3-D modeling) add $35 animal
tumor (3-D modeling)
organ (3-D modeling)
training $600 day
machine use $100 hour
chronic ECG/arterial pressure measurements
full instrumentation/probes/analysis $250 animal
surgery (no probe provided) $80 animal
Transverse Aortic Constriction (TAC) $120 animal
PV loop $180 animal
Myocardial infarction $120 animal
Aortic banding $120 animal
Ischemic/reperfusion $120 animal
Minipump implantation and drug-induced cardiac hypertrophy model $40 plus pump
Minor surgery (IV injections, blood sample collection, etc). $40 procedure
Tissue harvesting $30 organ
Invasive hemodynamic measurements such as Pressure-Volume analysis
We currently have 2 systems at our disposal:
Our facility has almost 20 different probes for measuring PV loops in rats up to rabbits.
Blood pressure measurements can be obtained by invasive and non-invasive means, either acutely or chronically
Acute Measurements through Transonic/Scisence system
Directly through cannulas we make in house that prevents the cost associated with battery refurbishment of other systems.
chronic myocardial infarction
Transverse Aortic Constriction (TAC)
Pacing induced Heart Failure
Hypertension models: Endocrine (DOCA-salt), Environment (restraint stress induced), Pharmacological (NO based), Renal (2 Kidney, 1 clip), etc.
Surgical models of cardiovascular disease, viral infection through the use of in-house viral vector core, etc.
Our trained professionals can train personnel at our facility or come train you at your facility in performing surgery, echocardiography, animal handling, etc.
Direct recordings of diaphragmatic EMG and 2 lead EKG
Achieved through acute or chronic instrumentation by either direct or telemetry based systems.
Tissue harvesting (lungs, heart, kidney, etc)
2 treadmill systems for rodent exercise tolerance testing and training
We have systems for performing echocardiography in small rodents and large animals.
Respiratory Disease Animal Models Services
Animal Surgery and Echocardiography Core Facility has not received any reviews.
Animal Surgery and Echocardiography Core Facility has not received any endorsements.