Animal Surgery and Echocardiography Core Facility
About Animal Surgery and Echocardiography Core Facility
The Small Animal Core Facility provides Loyola University and outside researchers, including industry scientists, with a central resource for creating and studying cardiovascular physiology and pathophysiology in animal models on a fee-for-service basis.
While the central focus of the facility is... Show more »
The Small Animal Core Facility provides Loyola University and outside researchers, including industry scientists, with a central resource for creating and studying cardiovascular physiology and pathophysiology in animal models on a fee-for-service basis.
While the central focus of the facility is cardiovascular research, the techniques employed are useful to a number of investigators in other fields. Currently, the facility is conducting studies focusing on burn and shock trauma, gene targeting, heart failure and other cardiovascular diseases. In addition to studying disease, the core can also provide laboratory teaching for various surgical techniques and echocardiography.
Services are oriented towards providing investigators with data suitable for use in grant proposals and manuscripts. Researchers work with the core facility scientists to assess their needs and provide the appropriate level of technical and scientific assistance.
Echocardiography
cardio (2-D B mode short and long axis, m-mode, doppler flow) $100 animal
cardio (tissue doppler) add $30 animal
cardio (strain) add $30 animal
cardio (simpson’s) add $30 animal
cardio (3-D modeling) add $35 animal
tumor (3-D modeling)
organ (3-D modeling)
training $600 day
machine use $100 hour
chronic ECG/arterial pressure measurements
full instrumentation/probes/analysis $250 animal
surgery (no probe provided) $80 animal
Transverse Aortic Constriction (TAC) $120 animal
PV loop $180 animal
Myocardial infarction $120 animal
Aortic banding $120 animal
Ischemic/reperfusion $120 animal
Minipump implantation and drug-induced cardiac hypertrophy model $40 plus pump
Minor surgery (IV injections, blood sample collection, etc). $40 procedure
Tissue harvesting $30 organ
Certifications & Qualifications
Our Services (29)
Pulmonary Hypertension Animal Models
Custom Animal Models
- We provide customized model development to meet the individual needs of the researcher at a fraction of the cost of an initial equipment investment and maintenance (i.e. Myocardial infarction, TAC, pacing, hypertension, etc).
- Data is produced efficiently and consistently.
- Our staff has a broad knowledge base in cardiovascular physiology and animal surgery.
- We provide customized model development to meet the individual needs of the researcher at a fraction of the cost of an initial equipment investment and maintenance (i.e. Myocardial infarction, TAC, pacing, hypertension, etc).
- Data is produced efficiently and consistently.
- Our staff has a broad knowledge base in cardiovascular physiology and animal surgery.
Animal Hemodynamics
Invasive hemodynamic measurements such as Pressure-Volume analysis
We currently have 2 systems at our disposal:
Transonic/Scisense
Millar
Our facility has almost 20 different probes for measuring PV loops in rats up to rabbits.
Invasive hemodynamic measurements such as Pressure-Volume analysis
We currently have 2 systems at our disposal:
Transonic/Scisense
Millar
Our facility has almost 20 different probes for measuring PV loops in rats up to rabbits.
Tail Cuff Blood Pressure Monitoring
Blood pressure measurements can be obtained by invasive and non-invasive means, either acutely or chronically
DSI system
Acute Measurements through Transonic/Scisence system
Directly through cannulas we make in house that prevents the cost associated with battery refurbishment of other systems.
Blood pressure measurements can be obtained by invasive and non-invasive means, either acutely or chronically
DSI system
Acute Measurements through Transonic/Scisence system
Directly through cannulas we make in house that prevents the cost associated with battery refurbishment of other systems.
Custom Cardiovascular Animal Models
models include:
chronic myocardial infarction
ischemia/reperfusion
Transverse Aortic Constriction (TAC)
Pacing induced Heart Failure
Hypertension models: Endocrine (DOCA-salt), Environment (restraint stress induced), Pharmacological (NO based), Renal (2 Kidney, 1 clip), etc.
models include:
chronic myocardial infarction
ischemia/reperfusion
Transverse Aortic Constriction (TAC)
Pacing induced Heart Failure
Hypertension models: Endocrine (DOCA-salt), Environment (restraint stress induced), Pharmacological (NO based), Renal (2 Kidney, 1 clip), etc.
Surgical Animal Models
Surgical models of cardiovascular disease, viral infection through the use of in-house viral vector core, etc.
Surgical models of cardiovascular disease, viral infection through the use of in-house viral vector core, etc.
Laboratory Animal Surgical Training
Our trained professionals can train personnel at our facility or come train you at your facility in performing surgery, echocardiography, animal handling, etc.
Our trained professionals can train personnel at our facility or come train you at your facility in performing surgery, echocardiography, animal handling, etc.
Drug Discovery
- Assistance with drug studies, tissue collection, blood collection
- Stereotaxic cannula placement/drug administration in rats for cerebral injections
- Assistance with drug studies, tissue collection, blood collection
- Stereotaxic cannula placement/drug administration in rats for cerebral injections
Animal Electromyography
Direct recordings of diaphragmatic EMG and 2 lead EKG
Direct recordings of diaphragmatic EMG and 2 lead EKG
Animal Electrocardiography
Achieved through acute or chronic instrumentation by either direct or telemetry based systems.
Achieved through acute or chronic instrumentation by either direct or telemetry based systems.
Animal Tissue Procurement
Tissue harvesting (lungs, heart, kidney, etc)
Tissue harvesting (lungs, heart, kidney, etc)
Metabolic Cage Studies
Animal Exercise Testing
2 treadmill systems for rodent exercise tolerance testing and training
2 treadmill systems for rodent exercise tolerance testing and training
Animal Echocardiography
We have systems for performing echocardiography in small rodents and large animals.
Equipment includes:
1) Visualsonics Vevo 2100
2) Seimens Acuson Sequoia Ultrasound
Systems allow for:
Superb B-Mode (2D) imaging for anatomical visualization and quantification, with enhanced temporal resolution with frame rates up to... Show more »
We have systems for performing echocardiography in small rodents and large animals.
Equipment includes:
1) Visualsonics Vevo 2100
2) Seimens Acuson Sequoia Ultrasound
Systems allow for:
Superb B-Mode (2D) imaging for anatomical visualization and quantification, with enhanced temporal resolution with frame rates up to 740 fps (in 2D for a 4x4 mm FOV) , and enhanced image uniformity with multiple focal zones (included in base package)
M-Mode for visualization and quantification of wall motion in cardiovascular research, single line acquisition allows for the very high-temporal (1000 fps) resolution necessary for analysis of LV function
Anatomical M-Mode for adjustable anatomical orientation in reconstructed M-Mode imaging; software automatically optimizes field of view for maximum frame rate
Pulsed-Wave Doppler Mode (PW) for quantification of blood flow
Color Doppler Mode for detection of blood vessels including flow directional information and mean velocities; as well as for identification of small vessels not visible in B-Mode
Power Doppler Mode for detection and quantification of blood flow in small vessels not visible in B-Mode; increased frame rates allow for significantly faster data acquisition
Tissue Doppler Mode for quantification of myocardial tissue movement; for example in assessing diastolic dysfunction
Vevo MicroMarker® Nonlinear Contrast Agent Imaging – for quantification of relative perfusion & molecular expression of endothelial cell surface markers; enhanced sensitivity to Vevo MicroMarker contrast agents as linear tissue signal is suppressed
3D-Mode Imaging for anatomical and vascular visualization, when combined with either B-Mode, Power Doppler Mode or Nonlinear Contrast Imaging; allows for quantification of volume and vascularity within a defined anatomical structure
Digital RF-Mode for the acquisition and exportation of radio frequency (RF) data in digital format for further analysis; full screen acquisition provides a complete data set for more comprehensive analysis and tissue characterization.
Animal Motor Function Tests
Biospecimens
Animal Models and Studies
Animal Physiology Analyses
Animal Imaging
Drug Discovery & Development
Animal Biospecimens
Animal Cognition & Behavior Tests
Animal Model Housing and Maintenance
Biology
Animal Model in vivo Analyses
Respiratory Disease Animal Models
Respiratory Disease Animal Models Services
Respiratory Disease Animal Models Services
Cells and Tissues
Cardiovascular Animal Models
Animal Models of Disease
Not finding what you're looking for?
Get info on this provider's capabilities without requesting a quote.Jonathan Dugas PhD
Program Coordinator
campsmallanimalcorefacility
Animal Surgery and Echocardiography Core Facility has not received any reviews.
Animal Surgery and Echocardiography Core Facility has not received any endorsements.