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Animal Surgery and Echocardiography Core Facility

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Maywood, Illinois, US

About Animal Surgery and Echocardiography Core Facility

The Small Animal Core Facility provides Loyola University and outside researchers, including industry scientists, with a central resource for creating and studying cardiovascular physiology and pathophysiology in animal models on a fee-for-service basis.

While the central focus of the facility is... Show more »

The Small Animal Core Facility provides Loyola University and outside researchers, including industry scientists, with a central resource for creating and studying cardiovascular physiology and pathophysiology in animal models on a fee-for-service basis.

While the central focus of the facility is cardiovascular research, the techniques employed are useful to a number of investigators in other fields. Currently, the facility is conducting studies focusing on burn and shock trauma, gene targeting, heart failure and other cardiovascular diseases. In addition to studying disease, the core can also provide laboratory teaching for various surgical techniques and echocardiography.

Services are oriented towards providing investigators with data suitable for use in grant proposals and manuscripts. Researchers work with the core facility scientists to assess their needs and provide the appropriate level of technical and scientific assistance.

Echocardiography
cardio (2-D B mode short and long axis, m-mode, doppler flow) $100 animal
cardio (tissue doppler) add $30 animal
cardio (strain) add $30 animal
cardio (simpson’s) add $30 animal
cardio (3-D modeling) add $35 animal
tumor (3-D modeling)
organ (3-D modeling)
training $600 day
machine use $100 hour

chronic ECG/arterial pressure measurements
full instrumentation/probes/analysis $250 animal
surgery (no probe provided) $80 animal
Transverse Aortic Constriction (TAC) $120 animal
PV loop $180 animal
Myocardial infarction $120 animal
Aortic banding $120 animal
Ischemic/reperfusion $120 animal
Minipump implantation and drug-induced cardiac hypertrophy model $40 plus pump
Minor surgery (IV injections, blood sample collection, etc). $40 procedure
Tissue harvesting $30 organ

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Certifications & Qualifications

AAALAC BSL-1 BSL-2 DEA Schedule II DEA Schedule III IACUC

Our Services (29)


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Pulmonary Hypertension Animal Models

Price on request
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Custom Animal Models

Price on request
  • We provide customized model development to meet the individual needs of the researcher at a fraction of the cost of an initial equipment investment and maintenance (i.e. Myocardial infarction, TAC, pacing, hypertension, etc).
  • Data is produced efficiently and consistently.
  • Our staff has a broad knowledge base in cardiovascular physiology and animal surgery.
  • We provide customized model development to meet the individual needs of the researcher at a fraction of the cost of an initial equipment investment and maintenance (i.e. Myocardial infarction, TAC, pacing, hypertension, etc).
  • Data is produced efficiently and consistently.
  • Our staff has a broad knowledge base in cardiovascular physiology and animal surgery.
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Rabbit Guinea pig Mouse Rat Rodents

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Animal Hemodynamics

Price on request

Invasive hemodynamic measurements such as Pressure-Volume analysis

We currently have 2 systems at our disposal:
Transonic/Scisense
Millar

Our facility has almost 20 different probes for measuring PV loops in rats up to rabbits.

Invasive hemodynamic measurements such as Pressure-Volume analysis

We currently have 2 systems at our disposal:
Transonic/Scisense
Millar

Our facility has almost 20 different probes for measuring PV loops in rats up to rabbits.

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Rabbit Mouse Rat Rodents

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Tail Cuff Blood Pressure Monitoring

Price on request

Blood pressure measurements can be obtained by invasive and non-invasive means, either acutely or chronically

DSI system
Acute Measurements through Transonic/Scisence system
Directly through cannulas we make in house that prevents the cost associated with battery refurbishment of other systems.

Blood pressure measurements can be obtained by invasive and non-invasive means, either acutely or chronically

DSI system
Acute Measurements through Transonic/Scisence system
Directly through cannulas we make in house that prevents the cost associated with battery refurbishment of other systems.

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Custom Cardiovascular Animal Models

Price on request

models include:
chronic myocardial infarction
ischemia/reperfusion
Transverse Aortic Constriction (TAC)
Pacing induced Heart Failure
Hypertension models: Endocrine (DOCA-salt), Environment (restraint stress induced), Pharmacological (NO based), Renal (2 Kidney, 1 clip), etc.

models include:
chronic myocardial infarction
ischemia/reperfusion
Transverse Aortic Constriction (TAC)
Pacing induced Heart Failure
Hypertension models: Endocrine (DOCA-salt), Environment (restraint stress induced), Pharmacological (NO based), Renal (2 Kidney, 1 clip), etc.

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Surgical Animal Models

Price on request

Surgical models of cardiovascular disease, viral infection through the use of in-house viral vector core, etc.

Surgical models of cardiovascular disease, viral infection through the use of in-house viral vector core, etc.

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Laboratory Animal Surgical Training

Price on request

Our trained professionals can train personnel at our facility or come train you at your facility in performing surgery, echocardiography, animal handling, etc.

Our trained professionals can train personnel at our facility or come train you at your facility in performing surgery, echocardiography, animal handling, etc.

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Drug Discovery

Price on request
  • Assistance with drug studies, tissue collection, blood collection
  • Stereotaxic cannula placement/drug administration in rats for cerebral injections
  • Assistance with drug studies, tissue collection, blood collection
  • Stereotaxic cannula placement/drug administration in rats for cerebral injections
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Animal Electromyography

Price on request

Direct recordings of diaphragmatic EMG and 2 lead EKG

Direct recordings of diaphragmatic EMG and 2 lead EKG

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Animal Electrocardiography

Price on request

Achieved through acute or chronic instrumentation by either direct or telemetry based systems.

Achieved through acute or chronic instrumentation by either direct or telemetry based systems.

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Animal Tissue Procurement

Price on request

Tissue harvesting (lungs, heart, kidney, etc)

Tissue harvesting (lungs, heart, kidney, etc)

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Metabolic Cage Studies

Price on request
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Animal Exercise Testing

Price on request

2 treadmill systems for rodent exercise tolerance testing and training

2 treadmill systems for rodent exercise tolerance testing and training

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Animal Echocardiography

Price on request

We have systems for performing echocardiography in small rodents and large animals.
Equipment includes:
1) Visualsonics Vevo 2100
2) Seimens Acuson Sequoia Ultrasound
Systems allow for:
 Superb B-Mode (2D) imaging for anatomical visualization and quantification, with enhanced temporal resolution with frame rates up to... Show more »

We have systems for performing echocardiography in small rodents and large animals.
Equipment includes:
1) Visualsonics Vevo 2100
2) Seimens Acuson Sequoia Ultrasound
Systems allow for:
 Superb B-Mode (2D) imaging for anatomical visualization and quantification, with enhanced temporal resolution with frame rates up to 740 fps (in 2D for a 4x4 mm FOV) , and enhanced image uniformity with multiple focal zones (included in base package)
 M-Mode for visualization and quantification of wall motion in cardiovascular research, single line acquisition allows for the very high-temporal (1000 fps) resolution necessary for analysis of LV function
 Anatomical M-Mode for adjustable anatomical orientation in reconstructed M-Mode imaging; software automatically optimizes field of view for maximum frame rate
 Pulsed-Wave Doppler Mode (PW) for quantification of blood flow
 Color Doppler Mode for detection of blood vessels including flow directional information and mean velocities; as well as for identification of small vessels not visible in B-Mode
 Power Doppler Mode for detection and quantification of blood flow in small vessels not visible in B-Mode; increased frame rates allow for significantly faster data acquisition
 Tissue Doppler Mode for quantification of myocardial tissue movement; for example in assessing diastolic dysfunction
 Vevo MicroMarker® Nonlinear Contrast Agent Imaging – for quantification of relative perfusion & molecular expression of endothelial cell surface markers; enhanced sensitivity to Vevo MicroMarker contrast agents as linear tissue signal is suppressed
 3D-Mode Imaging for anatomical and vascular visualization, when combined with either B-Mode, Power Doppler Mode or Nonlinear Contrast Imaging; allows for quantification of volume and vascularity within a defined anatomical structure
 Digital RF-Mode for the acquisition and exportation of radio frequency (RF) data in digital format for further analysis; full screen acquisition provides a complete data set for more comprehensive analysis and tissue characterization.

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Vevo 2100 Sequoia Echo Rabbit Guinea pig Mouse Rat Show 6 more tags Show less

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Animal Motor Function Tests

Price on request
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Biospecimens

Price on request
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Animal Models and Studies

Price on request
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Animal Physiology Analyses

Price on request
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Animal Imaging

Price on request
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Drug Discovery & Development

Price on request
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Animal Biospecimens

Price on request
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Animal Cognition & Behavior Tests

Price on request
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Animal Model Housing and Maintenance

Price on request
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Biology

Price on request
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Animal Model in vivo Analyses

Price on request
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Respiratory Disease Animal Models

Price on request

Respiratory Disease Animal Models Services

Respiratory Disease Animal Models Services

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Cells and Tissues

Price on request
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Cardiovascular Animal Models

Price on request
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Animal Models of Disease

Price on request
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Jonathan Dugas PhD

Program Coordinator
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Animal Surgery and Echocardiography Core Facility has not received any reviews.

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