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Amylgen

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Montferrier sur Lez, FR

About Amylgen

Amylgen is a CRO proposing innovative in vivo models of ageing, psychiatric and neurodegenerative pathologies for the development of new medicines or nutraceuticals.


Amylgen is at your service to provide quick POC for your product as a food supplement for brain health and helps you to substantiate the efficacy of your product by preclinical studies in rodent models


Amylgen brings you preclinical scientific data for your product on

- Brain aging preservation

- Memory enhancement

- Antidepressant /anti anxiety effect

- Protection against Alzheimer’s disease


Amylgen has access to regulatory and clinical partners to aid in the preparation of health claims for EFSA or FDA and the commercialization of your product

Our Services (13)


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Sigma 1 receptor agonist/antagonist assays

Price on request

Characterization of agonist/antagonist properties of

potential sigma1 receptor ligands in vitro



We developed an original fast-screening in vitro assay based from the observation that the Sig-1R chaperone association to BiP is specifically modulated by agonistic activity of ligands (Meunier & Hayashi, J Pharmacol Exp Ther,2009, Fujimoti et al., Synapse, 2012). By using high affinity ELISA assay, this activity test allows a fast determination of agonist or antagonist property of tested compound.

 

We need almost 5-8mg of each compound (depending of their MW), and the MSDS of each compound (if possible). We have a preference for solid form but liquid is fine. If compounds are in their liquid form we suggest you to send them frozen.

 

The price of the assay is directly dependent of the number of compounds you want to test.

 

Experiments start at reception of your compounds at our facilities and is performed during the month following compounds reception.

sigma CNS/Neurology

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In vivo Pharmacology Studies

Price on request
Request a quote for more information about this service.

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Cognitive, Behavioral, and Psychiatric Animal Models

Price on request
  • Depression
  • Anxiety
  • Chronic restraint stress
  • Schizophrenia:
  •     MK801-induced hyperactivity
  •     D-amphetamine-induced hyperactivity
  •     Phencyclidine-induced hyperactivity
  • Sleep deprivation




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Neurodegeneration Animal Models

Price on request
Request a quote for more information about this service.

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Schizophrenia Animal Models

Price on request
  • MK801-induced hyperactivity
  • D-amphetamine-induced hyperactivity
  • Phencyclidine-induced hyperactivity



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Aging Animal Models

Price on request
  • Senescence Accelerated Mice (SAM)
  • D-galactose (D-Gal) intoxication model
  • Aged animals



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Amnesia Animal Models

Price on request
  • MK-801-induced cognitive deficit
  • Scopolamine-induced cognitive deficit
  • Phencyclidine-induced cognitive deficit



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Anxiety Animal Models

Price on request
Request a quote for more information about this service.

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Depression Animal Models

Price on request
Request a quote for more information about this service.

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Cognition and Behavior Animal Models

Price on request
  • Y-maze
  • T-maze
  • Passive avoidance
  • Object recognition test
  • Morris water-maze



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Parkinsons Disease Animal Models

Price on request
  • 6-hydroxydopamine (6-OHDA)
  • α-synuclein overexpression



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Alzheimer's Disease Animal Models

Price on request
  • Central injection of Aβ25-35 peptide
  • Sporadic pathology (SAM)



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ALS Animal Models

Amyotrophic Lateral Sclerosis Animal Models
Price on request
  • SOD1*G93A mouse model (valid license agreement with Northwestern University)


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LC

Laura Ceolin

Global Studies Manager

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