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AM Chemicals, LLC

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Oceanside, California, US

About AM Chemicals, LLC

Established in 2003, AM Chemicals is a key player in the arena of universal solid supports and reagents for oligonucleotide synthesis. The stringent product specifications as well as batch to batch consistency of each of the products are achieved through exceptional internal quality control processes. We offer high quality products and an uncompromising commitment to excellence in our technical support.

AM Chemicals offers services in expert synthesis of radiolabeled oligonucleotides and their phosphorothioate analogs. We synthesize radiolabeled, protected nucleoside phosphoramidite reagents required for the incorporation of the desired radiolabels into oligonucleotides, carry out oligo synthesis, deprotect, purify, and desalt the target radiolabeled oligonucleotides.

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Small business

Our Services (8)


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Radiolabeling/Radiosynthesis

Price on request

Custom Radiolabeling of Synthetic Oligonucleotides

AM Chemicals offers services in expert synthesis of 14C, 35S and 3H radiolabeled oligonucleotides and their phosphorothioate analogs (1 to 100 mmol of isolated product) including:

  • Synthesis of [14C] - and [3H] -labeled, protected nucleoside phosphoramidite building blocks
  • Synthesis of the target radiolabeled oligonucleotides
  • Purification by reverse-phase or ion-exchange HPLC as requested by customer and desalting
  • For siRNA, forming a duplex by hybridization with the unlabeled strand
  • Optionally, confirmation of structure by ES MS
  • Optionally, removal of endotoxin from the final product
  • Optionally, performing above operations under GMP conditions

Custom Quote

​AM Chemicals is pleased to provide a custom quote for radiolabeled oligonucleotide synthesis project.
To request the custom quote, please furnish the following information:

  • Oligonucleotide sequence
  • Desired radioisotope (14C, 35S, and 3H )
  • Placement of the radiolabeled nucleoside in the sequence
  • Desired specific activity (SA):
    • A single labeling affords SA of 30-40, 100-400, and 500-1500 Ci/mol for 14C, 35S, and 3H radioisotopes, respectively
  • Desired amount of radiolabel incorporated or amount of radiolabeled oligonucleotide
  • Customers’ ability to provide project-specific unlabeled phosphoramidites of modified nucleosides or non-nucleosidic moieties

Guidelines for Optimal Cost Control of Radio-labeling Project

​- Awareness of radiolytic degradation saves money: aim for the specific activity of the target oligonucleotide as low as permissible

  • Use [4-^14C] -thymidine or 35S as carriers of the radiolabel
  • Placement of the radiolabeled moiety: close to the 5'-terminus of the target oligonucleotide
  • Provide project-specific unlabeled phosphoramidites of nucleosides or non-nucleosidic moieties
  • For shipping, solution is a preferred physical state of the finished product (oligo)
  • Acknowledge lead time for radio-labeling project (8 to 12 weeks) and plan ahead


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DNA Services

Price on request

DNA Services


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DNA Synthesis and Probe Development

Price on request

DNA Synthesis and Probe Development Services


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Nucleic Acid Services

Price on request

Nucleic Acid Services


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Biochemistry & Molecular Biology

Price on request

Biochemistry & Molecular Biology Services


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Biology

Price on request

Biology Services


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Radiochemistry

Price on request

Radiochemistry Services


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Chemistry and Materials

Price on request

Chemistry and Materials Services


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Andrei Guzaev

President & CSO

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