AM Biotechnologies develops DNA-based affinity agents called thioaptamers using unique chemistries and a proprietary bead-based selection process. Antibodies are currently the most widely-used affinity agents but they are produced in animals; are easily degraded; are expensive to produce; and suffer from batch-to-batch variability. In contrast, thioaptamers are chemically synthesized; they are stable in ambient environments with very long shelf life; and are rapidly produced in large quantities with easy quality control. We solve the problems associated with antibodies while delivering the same functionality. Thioaptamers can be substituted for antibodies in virtually any application. We can develop thioaptamer affinity agents for your targets using our bead-based development service.
AM also offers DNA thiophosphoramidite reagents via a strategic partnership with Glen Research Corporation and the RNA thiophosphoramidites are near market introduction. These unique reagents are used to synthesize thioaptamers and are also highly useful for providing in vivo stability and increased potency in RNAi applications.
The company was founded in 2006 and is primarily owned by two corporations. It has been awarded numerous SBIR grants and has also benefited from over $10M of prior university research into its technologies. Importantly, all of our technologies have freedom to operate.
Contract Thioaptamer Discovery
AM Biotechnologies can discover thioaptamer binding agents for your target. We will identify the sequence and dithioate backbone modifications that provide the best performance characteristics for customer-selected targets using our bead-based discovery process.
• Customer provides the target and information regarding special requirements
• AM will select the sequence and backbone modifications that best meet customer requirements
• AM will test the sequences discovered and deliver a small quantity of the best thioaptamers along with the sequence/modification information
• Virtually any customer-specified chemical modification can be used during the selection of the binding agents
AM works with synthesis partners to deliver custom oligos with the dithio backbone or other chemical modification.
AM develops custom thiophosphoramidite reagents for DNA and RNA synthesis. Our chemists have extensive experience with this unique chemistry and can develop new reagents based upon phosphorodithioate chemistry for our customers.
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