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Alpha Nano Tech LLC

Chapel Hill, North Carolina, US

Each nanoparticle formulation is unique, and each instrument or technique has it's optimal range and certain limitations. We chose particular technique for each nanoparticle sample taking into account what is the nature of that sample and what information that method can give us, and perform rigorous method validation and optional cross-validation using other techniques.

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Nanoparticle Tracking Analysis
Price on request

Nanoparticle Tracking Analysis Nanosight

Nanosight LM10-HS (Malvern) provides accurate nanoparticles size and concentration measurement in the range 30-1000nm. Instrument requires only 0.5 mL of the sample with concentration range 10^7 to 10^9 particles/mL. This technique is most widely used in exosome analysis. Unlike DLS... Show more »

Nanoparticle Tracking Analysis Nanosight

Nanosight LM10-HS (Malvern) provides accurate nanoparticles size and concentration measurement in the range 30-1000nm. Instrument requires only 0.5 mL of the sample with concentration range 10^7 to 10^9 particles/mL. This technique is most widely used in exosome analysis. Unlike DLS (dynamic light scattering) Nanosight is capable of resolving sub-populations of particles with close size. Turn around for orders under 20 samples - 3-5 business days.

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DLS
Laser Diffraction
Nanosight
NTA
TEM
SEM
Zetasizer
qNano
TRPS
Laser Diffraction Analysis
Price on request

Laser diffraction analysis of size and size distribution of the particles in solution in the range 100nm-900um.

Laser diffraction analysis of size and size distribution of the particles in solution in the range 100nm-900um.

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Karl Fischer Titration
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Potentiometric titration for determination of water content in solutions and dry powders.

Potentiometric titration for determination of water content in solutions and dry powders.

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Dynamic Light Scattering
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By Zeta-sizer Nano ZS (Malvern) to evaluate particles size and size distribution

By Zeta-sizer Nano ZS (Malvern) to evaluate particles size and size distribution

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Transmission Electron Microscopy (TEM)
Transmission Electron Microscopy services
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200Kv transmission electron microscopy to cross-validate other techniques or aquire images

200Kv transmission electron microscopy to cross-validate other techniques or aquire images

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Zeta Potential Measurements
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Zetasizer Nano ZS (Malvern) requires minimum of 0.5 mL of sample in electrolyte (PBS, NaCl solutions fit), analysis turnaround time - 5 business days. Instrument report will be provided.

Zetasizer Nano ZS (Malvern) requires minimum of 0.5 mL of sample in electrolyte (PBS, NaCl solutions fit), analysis turnaround time - 5 business days. Instrument report will be provided.

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Zetasizer Nano ZS
Zetasizer
HPLC-DAD
High Performance Liquid Chromatography Coupled with Diode Array Detection
Price on request

Method development, qualification and validation. Method development to include LOD, LOQ, Linearity, Accuracy, Precision.

Method development, qualification and validation. Method development to include LOD, LOQ, Linearity, Accuracy, Precision.

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Particle Size Distribution
Price on request

From 1 nm to 1000 um: we use laser diffraction (X-100 by Microtrac and Spraytec by Malvern) to analyze dry powder particels, nasal sprays, aerosols, inhalers and solutions of microparticles and DLS (Zetasizer Nano ZS by Malvern), NTA (Nanosight by Malvern), TRPS (qNano by Izon) for analysis of nanoparticles. Electron microscope by TEM/SEM is offered to confirm achieved data.

From 1 nm to 1000 um: we use laser diffraction (X-100 by Microtrac and Spraytec by Malvern) to analyze dry powder particels, nasal sprays, aerosols, inhalers and solutions of microparticles and DLS (Zetasizer Nano ZS by Malvern), NTA (Nanosight by Malvern), TRPS (qNano by Izon) for analysis of nanoparticles. Electron microscope by TEM/SEM is offered to confirm achieved data.

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Malvern
DLS
Laser Diffraction
Nanosight
Zetasizer
NTA
Microtrac
Spraytec
Exosome Isolation and Characterization
Price on request

Exosomes and extracellular vesicles (EV) play important roles in myriad of biological processes and are widely studied. Biological matrix, isolation and purification steps, heterogeneity of particles’ size make characterization of exosomes considerably complex for most techniques available on the market. Over the past few years... Show more »

Exosomes and extracellular vesicles (EV) play important roles in myriad of biological processes and are widely studied. Biological matrix, isolation and purification steps, heterogeneity of particles’ size make characterization of exosomes considerably complex for most techniques available on the market. Over the past few years Nanoparticle Tracking Analysis (NTA) and Tunable Resistive Pulse Sensing (TRPS) technology by Izon were found to be the most suitable and reliable techniques for analysis of variety of nanoparticles, and found to be exceptionally suitable for exosomes characterization.

NTA sinultaneously identifies and tracks each individual particle moving under Brownian motion and relates movement trajectory to particle size. It results in exceptional capability to resolve and count particles of different size in the mixture.

TRPS is an impedance-based system and is the only technique that can deliver three fundamental parameters of nanoparticles:

  • Particle concentration, being the number of particles/ml for a specified size range
  • Particle size and accurate number based size distribution, derived on a real particle by particle basis
  • Particle charge and number based charge distribution, also derived on a real particle by particle basis.

A voltage is applied across a pore that is filled with electrolyte, resulting in an ionic current. As particles cross the pore they briefly increase electrical resistance, creating a resistive pulse, which is precisely proportional to particle volume. TRPS represents a rapid, convenient, accurate and reproducible method for nanoparticle analysis.

Both Nanosight and qNano are excellent complimentary tools to study and characterize exosomes. AlphaNanoTech operates with Nanosight NS200-HS (Malvern) and qNano (IZON). Cross-validation by Dynamic Light Scattering (DLS) and SEM/TEM imaging is available upon request.

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Nanoscale Analysis and Characterization
Price on request

AlphaNanoTech provides top level nanoparticle characterization services with following optional cross-validation by Tunable Resistive Pulse Sensing (TRPS) qNano technology by Izon, Nanoparticle tracking analysis by Malvern Nanosight, and SEM/TEM imaging.

APPLICATIONS

Exosomes and Extracellular vesicles

Exosomes and... Show more »

AlphaNanoTech provides top level nanoparticle characterization services with following optional cross-validation by Tunable Resistive Pulse Sensing (TRPS) qNano technology by Izon, Nanoparticle tracking analysis by Malvern Nanosight, and SEM/TEM imaging.

APPLICATIONS

Exosomes and Extracellular vesicles

Exosomes and microvesicles play important role in transmission of biological signals between cells. Pathophysiological role of exosomes is beginning to be realized in cancer, neurodegenerative diseases, infectious diseases and other conditions. They are also attracting significant interest as drug delivery and transfection vehicles.

Nanoparticles

Nanoparticles as drug delivery systems gained a lot of attention in past few decades. There is number of FDA approved nanomedicines on the market for treatment of cancer, infectious diseases, cardiac/vascular disorders, viral infections, and others. Nanoparticles are also used in vaccines, cosmetics, for imaging nad theranostics.

Vaccines

Aggregation state of viral particles or adjuvant, as well as their count is crucial to understand and optimize vaccine's biological activity and evaluate long term stability.

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Analytical Chemistry Services
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Chemistry and Materials
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Electron Microscopy
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Liquid Chromatography
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Spectroscopy
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Pharmacology & Toxicology
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Bioanalysis
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Purification Services
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Scattering Techniques
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Engineering and Fabrication
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Chromatography
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Microscopy
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Material Testing Services
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Biomarkers
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Imaging & Spectroscopy
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Physical Analysis Methods
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2018-08-03 18:20:28 -0500

Net Promoter Score of 10 received for Karl Fischer Titration.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-04-24 14:23:07 -0500

Net Promoter Score of 10 received for Nanoparticle Tracking Analysis.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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