Aldevron has been perfecting plasmid DNA production since 1998. With the successful completion of over 60,000 projects, we have developed unsurpassed expertise in plasmid manufacturing. Using proprietary technology, Aldevron manufactures DNA for a wide range of research, preclinical, clinical, and diagnostic applications. Whether you require 1 mg of DNA for a research study or 100 g for a clinical trial, our goal is to be your vendor of choice and provide you with the most affordable, high-quality plasmid DNA manufacturing services that ensure your satisfaction.
Over the last 10 years, Aldevron has become the world's leading provider of plasmid purification services. With the successful completion of over 50,000 projects, we have developed unsurpassed expertise in plasmid manufacturing. Using proprietary technology, Aldevron manufactures DNA for a wide range of research, preclinical, clinical, and diagnostic applications.
Whether you require 1 mg of DNA for a research study or 100 g for a clinical trial, our goal is to be your vendor of choice and provide you with the most affordable, high-quality plasmid DNA manufacturing services that ensure your satisfaction.
Aldevron's research-grade production takes place in a facility separate from our clinical manufacturing laboratories and provides the flexibility we need to offer the competitive pricing and rapid turnaround times while still maintaining the quality expected under the appropriate levels of product scrutiny from our QA and QC departments. The scope of the services we offer are broken down in the following sections.
Small-Scale (0.5 to 20 mg)
Aldevron's small-scale production services are often used for transfection and screening studies requiring greater quantities of DNA and more stringent release specifications. Five to seven business day turnaround times are typical for orders of 20-50 preps. Aldevron's standard small scale plasmid production includes:
Mid-Scale (20 to 200 mg)
In this range of production, Aldevron includes a multi-host cell screening and cell banking operation as part of the service. In those instances where vector stability and/or yield are known issues, we can help identify favorable growth conditions. The plasmids manufactured at this scale typically undergo two to three disparate forms of chromatography. Step recovery rates are greatly improved through the use of tangential or hollow fiber flow systems, which eliminate precipitation and allow plasmids as large as 20 kb to be sterile filtered. DNA manufactured at this scale is typically used in formulation experiments, preclinical studies in larger animal models (e.g., rabbits and primates), validation work, and toxicology studies. Aldevron's mid-scale plasmid production ensures:
Large-Scale (0.2 to 20 g)
Aldevron interacts closely with clients to assist with the preparation of regulatory documentation. Starting with the product release specifications and known construct traits, the Aldevron large-scale platform technologies are adapted to meet your requirements. In addition, the scale of the equipment used makes this quantity range appropriate for the purification of low-yielding and/or highly unstable plasmids. Large-scale plasmid production includes:
High-Throughput Production (up to 0.5 mg)
With fast, industry leading turnaround times and unsurpassed quality at any scale, we make it easy to choose Aldevron for your routine high-throughput plasmid preps. In many instances you'll receive your DNA the same week you send it. Our high-throughput production provides:
Microgram to gram quantities of ultrapure, linearized plasmid vectors are provided using a highly scalable, enzymatic digestion and multi-mode chromatography process. The resulting products can be used for a variety of applications including hybridization assays, PCR cloning, and ligation-ready kit components. Aldevron's linearization includes:
Enabled by key license agreements, Aldevron provides researchers with the most viable production option for these increasingly important gene delivery vectors. You can expect:
Aldevron will work closely with you to manufacture products under your label and with your documentation requirements. Our quality infrastructure will give you a high level of assurance that can be passed on to your end users. In addition, Aldevron can provide non-GMP and GMP OEM services.
Aldevron is pleased to offer our clients full-featured gene synthesis capability to compliment our best-in-class plasmid, protein, and antibody manufacturing platforms.
Our client relations specialists can handle your request seamlessly from sequence or accession number, straight through to deliverable material manufactured to your specifications. Aldevrons’ state-of-the-art quality systems ensure your material will meet your exacting standards.
Sequence design and optimization, synthesis, cloning (standard pUC57), sequence verification, restriction digestion, and plasmid preparation to most any specification required from research through clinical applications.
Approximately 2 - 3 weeks for <2 kb synthetic genes
Aldevron’s on-campus storage facility offers a controlled, secure and reliable site to house clients’ precious material. We offer storage options from -80º C to ambient temperatures. The controlled access facility is fully monitored at all times. Aldevron’s proprietary data management system has the capacity to manage thousands of critical samples with on demand shipments to all over the world.
In cooperation with our Quality Control department, Aldevron can offer stability testing tailored to your timeline, testing needs and budget. Aldevron’s full panel of quality control assays is available to create the ideal custom study for each client.
QC Assays for Stability Testing
"Working with Aldevron has been a regrettable experience! It took them additional four weeks to complete a routine cloning and scale up order. They originally quoted us a turnaround time of two weeks, but they would come back to us with excuse after excuse of why the order keeps getting delayed. Please stay away from using this company, it's not worth your time. We will no longer use Aldevron in the future and have warned others to avoid using them."
"they did good job."
"A great Service provider with great customer service."
Aldevron - DNA has not received any endorsements.