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Aldevron - DNA

Fargo, North Dakota, US

Aldevron has been perfecting plasmid DNA production since 1998. With the successful completion of over 60,000 projects, we have developed unsurpassed expertise in plasmid manufacturing. Using proprietary technology, Aldevron manufactures DNA for a wide range of research, preclinical, clinical, and diagnostic applications. Whether you require 1 mg of DNA for a research study or 100 g for a clinical trial, our goal is to be your vendor of choice and provide you with the most affordable, high-quality plasmid DNA manufacturing services that ensure your satisfaction.

Aldevron - DNA has not listed any services.

Cell Paste
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Polyclonal Antibody Production
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Plasmid DNA Preparation
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Over the last 10 years, Aldevron has become the world's leading provider of plasmid purification services. With the successful completion of over 50,000 projects, we have developed unsurpassed expertise in plasmid manufacturing. Using proprietary technology, Aldevron manufactures DNA for a wide range of research, preclinical,... Show more »

Over the last 10 years, Aldevron has become the world's leading provider of plasmid purification services. With the successful completion of over 50,000 projects, we have developed unsurpassed expertise in plasmid manufacturing. Using proprietary technology, Aldevron manufactures DNA for a wide range of research, preclinical, clinical, and diagnostic applications.

Whether you require 1 mg of DNA for a research study or 100 g for a clinical trial, our goal is to be your vendor of choice and provide you with the most affordable, high-quality plasmid DNA manufacturing services that ensure your satisfaction.

Aldevron's research-grade production takes place in a facility separate from our clinical manufacturing laboratories and provides the flexibility we need to offer the competitive pricing and rapid turnaround times while still maintaining the quality expected under the appropriate levels of product scrutiny from our QA and QC departments. The scope of the services we offer are broken down in the following sections.

Small-Scale (0.5 to 20 mg)
Aldevron's small-scale production services are often used for transfection and screening studies requiring greater quantities of DNA and more stringent release specifications. Five to seven business day turnaround times are typical for orders of 20-50 preps. Aldevron's standard small scale plasmid production includes:

  • Chemistries and QC release specifications tailored to meet your specific needs
  • Unmatched turnaround times

Mid-Scale (20 to 200 mg)
In this range of production, Aldevron includes a multi-host cell screening and cell banking operation as part of the service. In those instances where vector stability and/or yield are known issues, we can help identify favorable growth conditions. The plasmids manufactured at this scale typically undergo two to three disparate forms of chromatography. Step recovery rates are greatly improved through the use of tangential or hollow fiber flow systems, which eliminate precipitation and allow plasmids as large as 20 kb to be sterile filtered. DNA manufactured at this scale is typically used in formulation experiments, preclinical studies in larger animal models (e.g., rabbits and primates), validation work, and toxicology studies. Aldevron's mid-scale plasmid production ensures:

  • Elimination of precipitation steps to maximize recovery and favor formulation-intensive studies
  • Impurity levels below most clinical specifications using multi-modal chromatography
  • Favorable vector-host combinations that assist in the next level of production
  • A decade of expertise handling even the most challenging projects

Large-Scale (0.2 to 20 g)
Aldevron interacts closely with clients to assist with the preparation of regulatory documentation. Starting with the product release specifications and known construct traits, the Aldevron large-scale platform technologies are adapted to meet your requirements. In addition, the scale of the equipment used makes this quantity range appropriate for the purification of low-yielding and/or highly unstable plasmids. Large-scale plasmid production includes:

  • A fully automated scalable system
  • Extensive in-process QC testing
  • Close interaction and process tailoring to meet client needs

High-Throughput Production (up to 0.5 mg)
With fast, industry leading turnaround times and unsurpassed quality at any scale, we make it easy to choose Aldevron for your routine high-throughput plasmid preps. In many instances you'll receive your DNA the same week you send it. Our high-throughput production provides:

  • Demonstrated capability through 400 preps/day with ability to expand further
  • Multiple entry points including electronic sequences, DNA, glycerol stocks and more
  • Chemistries and QC release specifications tailored to meet your specific needs

Linearized Vectors
Microgram to gram quantities of ultrapure, linearized plasmid vectors are provided using a highly scalable, enzymatic digestion and multi-mode chromatography process. The resulting products can be used for a variety of applications including hybridization assays, PCR cloning, and ligation-ready kit components. Aldevron's linearization includes:

  • Removal of unwanted fragments
  • Optimized step recoveries to maintain yield
  • Incorporation of client specifications into our QC system

Minicircles
Enabled by key license agreements, Aldevron provides researchers with the most viable production option for these increasingly important gene delivery vectors. You can expect:

  • Seamless integration of your gene into the appropriate vector
  • Ultra low prokaryotic remnants
  • Cell banking of the transformed host
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Competent Cell Production
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Aldevron will work closely with you to manufacture products under your label and with your documentation requirements. Our quality infrastructure will give you a high level of assurance that can be passed on to your end users. In addition, Aldevron can provide non-GMP and GMP OEM services.

Aldevron will work closely with you to manufacture products under your label and with your documentation requirements. Our quality infrastructure will give you a high level of assurance that can be passed on to your end users. In addition, Aldevron can provide non-GMP and GMP OEM services.

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Gene Synthesis
Price on request

Aldevron is pleased to offer our clients full-featured gene synthesis capability to compliment our best-in-class plasmid, protein, and antibody manufacturing platforms.

Our client relations specialists can handle your request seamlessly from sequence or accession number, straight through to deliverable material manufactured to... Show more »

Aldevron is pleased to offer our clients full-featured gene synthesis capability to compliment our best-in-class plasmid, protein, and antibody manufacturing platforms.

Our client relations specialists can handle your request seamlessly from sequence or accession number, straight through to deliverable material manufactured to your specifications. Aldevrons’ state-of-the-art quality systems ensure your material will meet your exacting standards.

Full Service
Sequence design and optimization, synthesis, cloning (standard pUC57), sequence verification, restriction digestion, and plasmid preparation to most any specification required from research through clinical applications.

Rapid Turnaround
Approximately 2 - 3 weeks for <2 kb synthetic genes

Standard Deliverables:

  • 2-5 ug (depending on vector) of lyophilized plasmid containing the desired synthetic construct
  • Certificate of Analysis (COA) including restriction digest
  • Sequence trace data with alignment
  • Sequence of synthetic gene alone and in vector
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Human Biobanking
Price on request

Aldevron’s on-campus storage facility offers a controlled, secure and reliable site to house clients’ precious material. We offer storage options from -80º C to ambient temperatures. The controlled access facility is fully monitored at all times. Aldevron’s proprietary data management system has the capacity to manage thousands of critical samples with on demand shipments to all over the world.

Aldevron’s on-campus storage facility offers a controlled, secure and reliable site to house clients’ precious material. We offer storage options from -80º C to ambient temperatures. The controlled access facility is fully monitored at all times. Aldevron’s proprietary data management system has the capacity to manage thousands of critical samples with on demand shipments to all over the world.

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Product Stability Testing
Price on request

In cooperation with our Quality Control department, Aldevron can offer stability testing tailored to your timeline, testing needs and budget. Aldevron’s full panel of quality control assays is available to create the ideal custom study for each client.

QC Assays for Stability Testing

In cooperation with our Quality Control department, Aldevron can offer stability testing tailored to your timeline, testing needs and budget. Aldevron’s full panel of quality control assays is available to create the ideal custom study for each client.

QC Assays for Stability Testing

  • Endotoxin Analysis by LAL Assay
  • Protein Content by BCA Assay
  • Spectrophotometry Analysis for Concentration
  • Spectrophotometry Analysis for Purity
  • BioBurden Monitoring
  • Purity by Gel Densitometry Analysis
  • pH Analysis
  • RNase and DNase Content
  • Quantitation of Residual Host Genomic DNA by qPCR
  • Final Product Appearance
  • USP <71> Sterility Test
  • Mycoplasma Detection
  • Restriction Endonuclease Analysis
  • Agarose Gel Electrophoresis
  • Detection of Residual RNA
  • DNA Sequence Analysis
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Biology
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Cells and Tissues
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Biospecimens
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Biospecimen Management and Storage
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Mammalian Cell Culture
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Biochemistry & Molecular Biology
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Protein Services
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Antibody Services
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Therapeutic Monoclonal Antibody (mAb) Development
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Nucleic Acid Services
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DNA Services
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DNA Synthesis and Probe Development
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Molecular Cloning
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Plasmids and Vectors
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Product Development, Testing, and Packaging
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2018-08-27 17:15:28 -0400

Net Promoter Score of 9 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2018-07-02 14:04:05 -0400

Net Promoter Score of 10 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-04-26 12:16:08 -0400

Net Promoter Score of 7 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 7.
2018-02-20 21:05:28 -0500

Net Promoter Score of 9 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 8.
2018-01-08 17:58:40 -0500

Net Promoter Score of 10 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-12-21 11:43:50 -0500

Net Promoter Score of 9 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
December 19, 2017

Negative review received for Plasmid DNA Preparation:

"Working with Aldevron has been a regrettable experience! It took them additional four weeks to complete a routine cloning and scale up order. They originally quoted us a turnaround time of two weeks, but they would come back to us with excuse after excuse of why the order keeps getting delayed. Please stay away from using this company, it's not worth your time. We will no longer use Aldevron in the future and have warned others to avoid using them."

2017-12-14 12:30:59 -0500

Net Promoter Score of 10 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
December 14, 2017

Positive review received for Plasmid DNA Preparation:

"they did good job."

2017-12-13 18:05:46 -0500

Net Promoter Score of 1 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 1, satisfaction with timeliness: 1.
September 20, 2017

Positive review received for Plasmid DNA Preparation:

"A great Service provider with great customer service."

2017-07-17 17:25:04 -0400

Net Promoter Score of 9 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 7.
2017-06-27 19:30:48 -0400

Net Promoter Score of 9 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 7.
2017-06-27 19:29:08 -0400

Net Promoter Score of 9 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 7.
2017-06-06 13:04:09 -0400

Net Promoter Score of 9 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 8.
2017-06-06 12:36:39 -0400

Net Promoter Score of 9 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 8.
2017-05-31 18:26:27 -0400

Net Promoter Score of 6 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 4, satisfaction with timeliness: 8.
2017-05-15 17:12:36 -0400

Net Promoter Score of 10 received for Plasmid DNA Preparation.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 8.

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