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Albert Einstein College of Medicine Genomics Core

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Bronx, New York, US

About Albert Einstein College of Medicine Genomics Core

The Genomics Core serves the Einstein scientific community by providing a broad scala of services, utilizing current and emerging nucleic acid technologies. Microarrays, real-time PCR, Sanger sequencing and new, massively parallel sequencing (MPS; also known as next-gen sequencing) are available. The Core... Show more »

The Genomics Core serves the Einstein scientific community by providing a broad scala of services, utilizing current and emerging nucleic acid technologies. Microarrays, real-time PCR, Sanger sequencing and new, massively parallel sequencing (MPS; also known as next-gen sequencing) are available. The Core provides a number of technologies for genotyping DNA from humans or model organisms, varying from SNP (single nucleotide polymorphism) detecting to sequencing DNA for unknown variations. Furthermore, the Genomics Core performs quantitative CpG methylation analysis for the Epigenomics Core.

Selected Publications

  • Gallagher RE, Schachter-Tokarz EL, Zhou DC, Ding W, Kim SH, Sankoorikal BJ, Bi W, Livak KJ, Slack JL, Willman CL. Relapse of acute promyelocytic leukemia with PML-RARalpha mutant subclones independent of proximate all-trans retinoic acid selection pressure. Leukemia, 2006 Apr;20(4):556-62
  • Niklaus AL, Pollard JW. Mining the mouse transcriptome of receptive endometrium reveals distinct molecular signatures for the luminal and glandular epithelium. Endocrinology, 2006 Jul;147(7):3375-90
  • Li Z, Zhao C, Iglesias-Ussel MD, Polonskaya Z, Zhuang M, Yang G, Luo Z, Edelmann W, Scharff MD. The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus. Immunity, 2006 Apr;24(4):393-403
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Our Services (21)


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Single Cell Immune Repertoire Sequencing

Price on request

Libraries prepared with 10x Genomics Chromium Instrument and 5' Gene Expression V(D)J Kit

Libraries prepared with 10x Genomics Chromium Instrument and 5' Gene Expression V(D)J Kit

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Single Cell RNA-Seq

Price on request

Libraries prepared with 10x Genomics Chromium Instrument and 3' Kit

Libraries prepared with 10x Genomics Chromium Instrument and 3' Kit

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DNA/RNA Analysis and Quality Control

Price on request
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Agilent Bioanalyzer

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Multiplex Gene Expression Analysis

Price on request

Sequenom QGE – multiplex quantitative gene expression and copy number analysis

Sequenom QGE – multiplex quantitative gene expression and copy number analysis

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qPCR

Quantitative PCR
Price on request
  • Real Time qPCR (ABI 7900) 384 well and 96 well instruments
    • Quantitative gene expression,
    • HRM (High Resolution Melting) – SNP discovery
    • Copy number analysis
  • Real Time qPCR (ABI 7900) 384 well and 96 well instruments
    • Quantitative gene expression,
    • HRM (High Resolution Melting) – SNP discovery
    • Copy number analysis
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DNA Microarrays

Price on request
  • Affymetrix Exon Arrays for gene expression and splice variant analysis
    • Gene 1.0 ST – new, lower cost arrays for gene expression
    • SNP 6.0 arrays: Genome-wide SNP and copy number variant typing- 1.8 M markers
  • NimbleGen – ChIP on Chip, HELP-Chip
  • Affymetrix Exon Arrays for gene expression and splice variant analysis
    • Gene 1.0 ST – new, lower cost arrays for gene expression
    • SNP 6.0 arrays: Genome-wide SNP and copy number variant typing- 1.8 M markers
  • NimbleGen – ChIP on Chip, HELP-Chip
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DNA Fragment Analysis

Price on request

Microsatellite markers; Multiplex Ligation-dependent Probe Amplification (MLPA) for detection of copy number and genomic disorders.

Microsatellite markers; Multiplex Ligation-dependent Probe Amplification (MLPA) for detection of copy number and genomic disorders.

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SNP Genotyping

Single Nucleotide Polymorphism Genotyping
Price on request

Sequenom iPLEX - multiplex SNP genotyping by Single Base Extension; 1-40 SNPs/assay

Sequenom iPLEX - multiplex SNP genotyping by Single Base Extension; 1-40 SNPs/assay

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DNA Methylation Analysis

Price on request
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Next Generation Sequencing (NGS)

Price on request
  • Illumina GAII—36+ bp reads; useful for large genomes
  • Roche 454—400+ bp reads; useful for de novo sequencing and microorganisms
  • Illumina GAII—36+ bp reads; useful for large genomes
  • Roche 454—400+ bp reads; useful for de novo sequencing and microorganisms
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Illumina Genome Analyzer II Sequencer Roche GS-FLX 454

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DNA Sequencing

Price on request

Traditional DNA sequencing (ABI 3730)- tubes for single samples or 96 well plates

  • Optional PCR or plasmid purification prior to sequencing

Traditional DNA sequencing (ABI 3730)- tubes for single samples or 96 well plates

  • Optional PCR or plasmid purification prior to sequencing
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Biochemistry & Molecular Biology

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Epigenetic Studies

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RNA Sequencing

Price on request

RNA Sequencing Services

RNA Sequencing Services

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RNA Services

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Nucleic Acid Services

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DNA Services

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Genotyping and Gene Expression Assays

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PCR

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Biology

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Single Cell Western Blot

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Up to 1000 cells captured on a ProteinSimple Milo Western Chip. Chip may be probed with up to 3 western antibodies, stripped and re-probed multiple times

Up to 1000 cells captured on a ProteinSimple Milo Western Chip. Chip may be probed with up to 3 western antibodies, stripped and re-probed multiple times

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