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AJES LifeSciences, LLC

Stony Brook, New York, US

AJES LifeSciences, LLC is founded with a vision to provide integrated R&D support in all the key areas of Pharmaceutical development. We offer proprietary orthotopic and metastases tumor models. Our services include, whole body animal imaging, small animal ultra sound MRI, CT scan and other advanced technologies. We provide a complete array of research services as required for Investigational New Drug Applications (IND). AJES LifeSciences at Stony Brook New York is fully committed to the judicious, humane use of animals in research and development.

Selected Publications

  • Bossi D, Carlomagno F, Pallavicini I, Pruneri G, Trubia M, Raviele PR, Marinelli A, Anaganti S, Cox MC, Viale G, Santoro M, Di Fiore PP, Minucci S. Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies. Mol Oncol. 2014 Mar;8(2):221-31. doi:10.1016/j.molonc.2013.11.004. Epub 2013 Nov 19. PubMed... Show more »

AJES LifeSciences, LLC is founded with a vision to provide integrated R&D support in all the key areas of Pharmaceutical development. We offer proprietary orthotopic and metastases tumor models. Our services include, whole body animal imaging, small animal ultra sound MRI, CT scan and other advanced technologies. We provide a complete array of research services as required for Investigational New Drug Applications (IND). AJES LifeSciences at Stony Brook New York is fully committed to the judicious, humane use of animals in research and development.

Selected Publications

  • Bossi D, Carlomagno F, Pallavicini I, Pruneri G, Trubia M, Raviele PR, Marinelli A, Anaganti S, Cox MC, Viale G, Santoro M, Di Fiore PP, Minucci S. Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies. Mol Oncol. 2014 Mar;8(2):221-31. doi:10.1016/j.molonc.2013.11.004. Epub 2013 Nov 19. PubMed PMID: 24315414; PubMed Central PMCID: PMC5528547.
  • Anaganti S, Fernández-Cuesta L, Langerød A, Hainaut P, Olivier M. p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines. Cancer Lett. 2011 Jan 28;300(2):215-24. doi: 10.1016/j.canlet.2010.10.008. Epub 2010 Nov 10. PubMed PMID: 21071137.
  • Fernandez-Cuesta L, Anaganti S, Hainaut P, Olivier M. p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines. Int J Cancer. 2011 Apr 15;128(8):1813-21. doi: 10.1002/ijc.25512. PubMed PMID: 20549698.
  • Fernández-Cuesta L, Anaganti S, Hainaut P, Olivier M. Estrogen levels act as a rheostat on p53 levels and modulate p53-dependent responses in breast cancer cell lines. Breast Cancer Res Treat. 2011 Jan;125(1):35-42. doi: 10.1007/s10549-010-0819-x. Epub 2010 Mar 11. PubMed PMID: 20221692.
  • Anaganti S, Hansen JK, Ha D, Hahn Y, Chertov O, Pastan I, Bera TK. Non-AUG translational initiation of a short CAPC transcript generating protein isoform. Biochem Biophys Res Commun. 2009 Mar 13;380(3):508-13. doi: 10.1016/j.bbrc.2009.01.089. Epub 2009 Jan 23. PubMed PMID: 19250639; PubMed Central PMCID: PMC2664252.
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Dermal Toxicity Studies
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Small Animal CT Scan
Small Animal Computed Tomography Scan
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Small Animal MRI
Small Animal Magnetic Resonance Imaging
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In vivo Toxicity Testing
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Acute Toxicity Study

To determine LD50, MTD or NOEL of test compounds and to determine the doses for repeated dose studies

Sub-acute Toxicity Study

To determine the repeated dose toxicity of test compounds and also the doses for chronic studies

Sub-chronic Toxicity Study

To establish NOEL, to identify and... Show more »

Acute Toxicity Study

To determine LD50, MTD or NOEL of test compounds and to determine the doses for repeated dose studies

Sub-acute Toxicity Study

To determine the repeated dose toxicity of test compounds and also the doses for chronic studies

Sub-chronic Toxicity Study

To establish NOEL, to identify and characterize the specific organs affected after repeated dosing and predict the appropriate dose for chronic toxicity studies

Chronic Toxicity Study

To establish to identify the cumulative toxicity, carcinogenic potential of the test compound and characterize the specific organs affected after repeated dosing

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In vitro Genotoxicity Testing
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AMES:

Biological assay to assess the mutagenic potential of chemical compounds.

Test system includes Salmonella typhimurium TA98 and/or TA100 using 6 concentrations of the test substance in the absence of metabolic activation

Potential solvents include: USP Water for Injection (WFI), USP 0.9% Sodium Chloride for... Show more »

AMES:

Biological assay to assess the mutagenic potential of chemical compounds.

Test system includes Salmonella typhimurium TA98 and/or TA100 using 6 concentrations of the test substance in the absence of metabolic activation

Potential solvents include: USP Water for Injection (WFI), USP 0.9% Sodium Chloride for Injection (NaCl), Dimethylsulfoxide (DMSO), Acetone, 95% Ethanol (EtOH), and Cottonseed Oil.

Micronucleus Test:

To assess the potential of a test material to induce genetic damage in vivo and determine toxicity

An Initial range finding study is performed using a maximum dose of 2,000-mg/kg body weight followed by four lower concentrations of the test substance using rodents

End points observed are signs of toxicity, loss of weight, clinical symptoms of toxicity, alteration of ratio of immature to mature red blood cells in the bone marrow and clastogenicity is measured as the proportion of micronucleated erythrocytes

Bone marrow smears are prepared after 24 and 48 hours of treatment. The treatment groups consist of negative, test, and positive control groups. The bone marrow smears are examined to count approximately 2,000 immature and a corresponding number of mature erythrocytes per animal in each group.

Potential solvents include: USP 0.9% Sodium Chloride for Injection (NaCl) and Cottonseed Oil.

Chromosomal Aberration Assay:

To assess the potential of a test material to induce genetic damage in vivo and determine toxicity

The cells are exposed to the test substance at three concentrations in the presence and absence of metabolic activation

The duration of study is TK+/- mouse lymphoma or CHO HGPRT mutation assay: 14 - 18 days

Test system includes rodents, mammalian-cells

Potential solvents include: Ham’s F12, Dimethylsulfoxide (DMSO), and 95% Ethanol (EtOH)

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Local Tolerance Studies
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Irritation and Sensitization

To determine the potential of a test material to provoke ocular, dermal irritation, or sensitization

The duration of study for Irritation - one hour to two weeks after a single topical or corneal administration, Sensitization – intra dermal or topical induction doses followed by topical... Show more »

Irritation and Sensitization

To determine the potential of a test material to provoke ocular, dermal irritation, or sensitization

The duration of study for Irritation - one hour to two weeks after a single topical or corneal administration, Sensitization – intra dermal or topical induction doses followed by topical challenges with a non-irritating dose

Endpoints include degree of erythema, edema, pruritis, papules, vesicles, corneal irritation, swelling, microscopic integrity of corneal endothelium, other features of the eye (conjuctive, cornea, iris, lens, opthalmascopy)

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Toxicology
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AJES toxicology Studies are designed for the evaluation of toxicity of test articles. These studies may be preliminary investigations/ early toxicology for internal review or for regulatory submissions and direct extrapolation to human safety.

Regulatory Guidelines:

AJES toxicology studies are designed as per major... Show more »

AJES toxicology Studies are designed for the evaluation of toxicity of test articles. These studies may be preliminary investigations/ early toxicology for internal review or for regulatory submissions and direct extrapolation to human safety.

Regulatory Guidelines:

AJES toxicology studies are designed as per major international guidelines applicable. Some of these include OECD, US FDA, EPA, EMEA, ICH, EC, ISO or USP.

Test Systems:

AJES offers testing services in rodents and non human primates.

Routes of Administration:

  • Oral
  • Subcutaneous
  • Intravenous injection
  • Interperitoneal
  • Percutaneous
  • Dermal
  • Vaginal
  • Rectal
  • Urinary Bladder
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Immunohistochemistry (IHC)
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Preclinical Histology
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FACS
Fluorescence Activated Cell Sorting
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Flow Cytometry
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Fluid Analysis
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  • Blood
  • Urine
  • CSF etc.,
  • Blood
  • Urine
  • CSF etc.,
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Immunoassays
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Orthotopic Tumor Animal Models
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AJES has over 15 years of experience using xenograft and orthotopic tumor models, Our cell bank offers a wide selection of fully characterized cell lines used in our animal studies. We also offer fully tested bioluminescence (BLS) and fluorescent (FLS) cell lines used in our orthotopic/metastatic tumor models. AJES is one of the... Show more »

AJES has over 15 years of experience using xenograft and orthotopic tumor models, Our cell bank offers a wide selection of fully characterized cell lines used in our animal studies. We also offer fully tested bioluminescence (BLS) and fluorescent (FLS) cell lines used in our orthotopic/metastatic tumor models. AJES is one of the leading companies that carry reference data on a wide selection of tumor growth analysis and standards of care.

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Xenograft Models
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AJES has over 15 years of experience using xenograft and orthotopic tumor models, Our cell bank offers a wide selection of fully characterized cell lines used in our animal studies. We also offer fully tested bioluminescence (BLS) and fluorescent (FLS) cell lines used in our orthotopic/metastatic tumor models. AJES is one of the... Show more »

AJES has over 15 years of experience using xenograft and orthotopic tumor models, Our cell bank offers a wide selection of fully characterized cell lines used in our animal studies. We also offer fully tested bioluminescence (BLS) and fluorescent (FLS) cell lines used in our orthotopic/metastatic tumor models. AJES is one of the leading companies that carry reference data on a wide selection of tumor growth analysis and standards of care.

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Diabetes Animal Models
Price on request
  • Type I Diabetes
    • Streptozotocin induced rat model
  • Type II Diabetes
    • Neonatal STZ induced rat model
    • STZ and Nicotinamide induced mice model
    • High fat diet and low dose STZ induced rat model
  • Type I Diabetes
    • Streptozotocin induced rat model
  • Type II Diabetes
    • Neonatal STZ induced rat model
    • STZ and Nicotinamide induced mice model
    • High fat diet and low dose STZ induced rat model
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Mouse
Rat
Rheumatoid Arthritis Animal Models
Price on request
  • Collagen induced arthritis rat model
  • Adjuvant arthritis rat model

AJES constantly makes new animal models and services available for our customers.

  • Collagen induced arthritis rat model
  • Adjuvant arthritis rat model

AJES constantly makes new animal models and services available for our customers.

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Rat
ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
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AJES drug metabolism and pharmacology group offers a wide range of in vivo and in vitro Drug Metabolism and Pharmacokinetics (DMPK) services.

  • Bio Analytical services
  • Drug metabolismand pharmacokinetics
  • Metabolomics

At AJES We offer a wide range of pharmacology and drug metabolism studies. Please contact our team for more information

AJES drug metabolism and pharmacology group offers a wide range of in vivo and in vitro Drug Metabolism and Pharmacokinetics (DMPK) services.

  • Bio Analytical services
  • Drug metabolismand pharmacokinetics
  • Metabolomics

At AJES We offer a wide range of pharmacology and drug metabolism studies. Please contact our team for more information

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Animal Models and Studies
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Animal Model in vivo Analyses
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Animal Imaging
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Animal Models of Disease
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Oncology Animal Models
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Metabolic Animal Models
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Immunology Animal Models
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Inflammation Animal Models
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Biology
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Cells and Tissues
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Cell and Tissue Culture
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Cytometry
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Biochemistry & Molecular Biology
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Protein Services
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Protein Expression Visualization
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Immunostaining
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Engineering and Fabrication
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Physical Analysis Methods
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Pharmacology & Toxicology
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In vitro Toxicity Testing
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In vitro Toxicity Testing Services

In vitro Toxicity Testing Services

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Drug Discovery & Development
Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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