Advanced Cell Diagnostics, Inc.
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Hayward, California, US
Advanced Cell Diagnostics (ACD) specializes in molecular pathology and develops cell/tissue based diagnostic assays for personalized medicine. RNAscope® is a proprietary RNA in situ hybridization (ISH) assay based on ACD patented signal amplification and background suppression technology which advances RNA biomarker analysis in tissues and cells. Unique to this technology, RNAscope® delivers quantitative, sensitive and specific molecular detection of RNA species on a cell-by-cell basis with morphological context in a single assay. This enables researchers to visualize which genes are expressed, localize where they are expressed, and quantify the level of expression. **KEY BENEFITS** MOLECULAR DETECTION Distinguish between RNA molecules of up to 85% sequence homology and with single copy detection MORPHOLOGICAL CONTEXT Visualize gene expression within individual cells in all regions of the tissue QUANTITATIVE Determine the number of RNA transcripts per cell and compare different regions of the tissue or across samples UNIVERSAL Apply to virtually ANY gene from ANY genome in ANY tissue SCALABLE Scale up with automation for routine high-throughput analysis
Use RNAscope to screen and validate candidate targets with single molecule sensitivity.
Partner with ACD to support the assay feasibility, proof of concept, and validation steps of your RNAscope CDx development efforts.
Use RNAscope to evaluate candidate biomarker expression and establish assay performance using bioanalytical validation parameters.
Advanced Cell Diagnostics’ Pharma Assay Services is the only laboratory services provider/contract research organization with the unique combination of qualifications for processing RNAscope or BaseScope assays. 1. ACD is the patent holder and only manufacturer of RNAscope and BaseScope Assay reagents and kits. Thus, any other laboratory services vendor will need to purchase necessary reagents from ACD. 2. Pharma Assay Services is housed in the same facility as ACD’s R&D and Technical Support Teams. This provides Pharma Assay Services with a unique access to scientific expertise and an extensive knowledge base from years of customer support. 3. Pharma Assay Services is housed in the same facility as the Probe Design Team, which is the sole provider of RNAscope or BaseScope probe designs. This provides for very rapid custom probe generation and performance customization as needed. 4. The Scientists and Specialists on the Pharma Assay Services team are dedicated to RNAscope and BaseScope ISH assays exclusively, with a high level of technical expertise and experience across hundreds of tissue types and tens of thousands of samples. 5. Data analysis, including visual scoring and software image analysis, are performed routinely by RNAscope ISH specialists. Board Certified Pathologists on the team provide pathology notes and reviews. 6. Pharma Assay Services possesses unique access to early access, pre-launched products from ACD. This provides for access to the most up-to-date capabilities related to ACD products. 7. PAS is uniquely qualified to perform Companion Diagnostic assay feasibility and ultimate transfer to CLIA laboratories. 8. PAS has access to eleven (11) Leica Bond RX or Ventana Discovery autostainer systems and can perform assays at a high throughput with fast turnaround times. 9. PAS is highly experienced in all available RNAscope and BaseScope assays, including chromogenic, fluorescent, singleplex, duplex, multiplex, manual, and automated assays. 10. PAS possesses an in-house pre-validated tissue sample bank. This provides for rapid assay turnaround and a high level of confidence in the tissue quality.
Use RNAscope to visualize the biodistribution of CAR-T or TCR-T cells within the tumor microenvironment and assess functionality with co-detection of immune cell markers or markers of activation.
Fluorescence in situ Hybridization (RNAscope in Fluorescence)
ACD offers a wide range of assay services for your biomarker validation and companion diagnostic development, utilizing our breakthrough RNAscope technology. Results are usually available approximately 6 weeks after receipt of specimens. By tapping into our world-leading assay development expertise, you will have the highest confidence in your results.
ACD offers a wide range of assay services for your biomarker validation and companion diagnostic development, utilizing our breakthrough RNAscope technology. Results are usually available approximately 6 weeks after receipt of specimens. By tapping into our world-leading assay development expertise, you will have the highest confidence in your results.
ACD offers a wide range of assay services for your biomarker validation and companion diagnostic development, utilizing our breakthrough RNAscope technology. Results are usually available approximately 6 weeks after receipt of specimens. By tapping into our world-leading assay development expertise, you will have the highest confidence in your results.
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