1319050460000

Advanced BioScience Laboratories

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Rockville, Maryland, US

About Advanced BioScience Laboratories

Founded: 1961 Type: Privately Held Size: 51-200 employees

Advanced BioScience Laboratories, Inc (ABL) is a leading contract research and manufacturing organization, partnering with our clients to advance their vaccine and therapeutic development programs. Our unique combination of preclinical and clinical services provide the tools to address the scientific challenges... Show more »

Advanced BioScience Laboratories, Inc (ABL) is a leading contract research and manufacturing organization, partnering with our clients to advance their vaccine and therapeutic development programs. Our unique combination of preclinical and clinical services provide the tools to address the scientific challenges encountered during any stage of product development. For preclinical studies, we utilize immunological, molecular, and cell-based assay platforms for candidate selection. We offer proof-of-concept in vivo studies with preclinical immunomonitoring and efficacy and potency testing. Once a clinical candidate is identified, ABL's in-house cGMP suites are designed for single-use technologies accommodating a wide range of products, including mammalian- and microbial-based protein therapeutics as well as viral vectors and vaccines.

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Certifications & Qualifications

GCLP ISO 9001

Our Services (60)


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Antigen Expression and Purification

Price on request

VIRAL ANTIGENS AND PROTEINS
ABL has the capability to produce highly pure native envelope and gag HIV-1 and SIV antigens. These native proteins are purified from the conditioned media of chronically infected Human T-cell lines using immunoaffinity chromatography. They are purified by reverse phase chromatography resulting in... Show more »

VIRAL ANTIGENS AND PROTEINS
ABL has the capability to produce highly pure native envelope and gag HIV-1 and SIV antigens. These native proteins are purified from the conditioned media of chronically infected Human T-cell lines using immunoaffinity chromatography. They are purified by reverse phase chromatography resulting in purities greater than 95%. In addition, we offer a biologically active recombinant HIV-1 Tat protein which is produced in E. coli and purified using heparin sepharose and reverse phase chromatography. Tat is greater than 95% pure and biologically active by an HIV-1 rescue assay.

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Adenovirus Production

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AAV Production

Adeno-associated virus (AAV) production
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Cell Proliferation Assays

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Lymphoproliferation assay

Lymphoproliferation assay

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Custom Cell-Based Assay Development

Price on request

PBMC and target cell based assays

Antibody-dependent cellular cytotoxicity (ADCC) / antibody-dependent cellular phagocytosis (ADCP)

PBMC and target cell based assays

Antibody-dependent cellular cytotoxicity (ADCC) / antibody-dependent cellular phagocytosis (ADCP)

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Cell Line Collections

Price on request

Mammalian cell lines
Microbial cell lines
Insect cell lines
Adherent and suspension-based processes
Adaptation to animal origin-free media
Up to 500 vials per bank

Mammalian cell lines
Microbial cell lines
Insect cell lines
Adherent and suspension-based processes
Adaptation to animal origin-free media
Up to 500 vials per bank

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Cytokine Analysis

Price on request

Cytokine detection / quantitation

Cytokine detection / quantitation

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ELISA

Enzyme-linked immunosorbent assay
Price on request

Custom / Commercial / Client Methods

Qualification, verification, or partial full validation

Custom / Commercial / Client Methods

Qualification, verification, or partial full validation

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FACS

Fluorescence Activated Cell Sorting
Price on request

Examine T-cell Responses by FACS
Examine B-Cell Responses by FACS
FACS analysis to determine production of IFN-gamma, TNF-alpha, IL-2, IL-4, IL-5, IL-6, IL-10, and other cytokines
Tetramer, Pentamer, Dextramer Staining Assays (TCR binding assays)

Examine T-cell Responses by FACS
Examine B-Cell Responses by FACS
FACS analysis to determine production of IFN-gamma, TNF-alpha, IL-2, IL-4, IL-5, IL-6, IL-10, and other cytokines
Tetramer, Pentamer, Dextramer Staining Assays (TCR binding assays)

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ELISpot Assays

Enzyme-Linked ImmunoSpot Assays
Price on request

ELISPOT / Fluorospot

ELISPOT / Fluorospot

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Immunofluorescence

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Immunophenotyping

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Lentivirus Production

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Biopharmaceutical Process Development

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ABL regularly conducts upstream and downstream development work for our clients - an essential step towards efficient design of cGMP-compliant manufacturing. We draw on our scientific, manufacturing and quality expertise to design production processes that optimize product yields and minimize regulatory risk. Our technical... Show more »

ABL regularly conducts upstream and downstream development work for our clients - an essential step towards efficient design of cGMP-compliant manufacturing. We draw on our scientific, manufacturing and quality expertise to design production processes that optimize product yields and minimize regulatory risk. Our technical approach incorporates the use of disposal, single use technologies to maximize flexible manufacturing capacities, reduce clean room turn around, and accelerate time to clinic.

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Serological Assays

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Vaccine Production

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Western Blot

Price on request

Semi-quantitative or detection

Semi-quantitative or detection

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Monoclonal Antibody (mAb) Production

Price on request

ABL has developed high affinity murine monoclonal antibodies (Mabs) against numerous retroviral proteins, including the envelope proteins gp120 and gp160. These antibodies are purified from ascites fluid or the conditioned media from hybridoma cultures using protein A sepharose. The resulting Mabs are highly reactive and specific.

ABL has developed high affinity murine monoclonal antibodies (Mabs) against numerous retroviral proteins, including the envelope proteins gp120 and gp160. These antibodies are purified from ascites fluid or the conditioned media from hybridoma cultures using protein A sepharose. The resulting Mabs are highly reactive and specific.

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qPCR

Quantitative PCR
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Site-Directed Mutagenesis

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Immunoassays

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Virus Production

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PCR

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Microbiology

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Vaccines

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Specialized Cell-Based Assays

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Model Organisms

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Bioanalysis

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Biospecimen Management and Storage

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Sample processing
- Whole Blood Processing (PBMCs, Serum, Plasma)
- Tissue Processing (Splenocytes, bone marrow aspirate, tumor, lymph node, gut, rectal, vaginal)
- Mucosal Immunology Experts - years of experience monitoring antibody and T-Cell response in mucosa

Sample processing
- Whole Blood Processing (PBMCs, Serum, Plasma)
- Tissue Processing (Splenocytes, bone marrow aspirate, tumor, lymph node, gut, rectal, vaginal)
- Mucosal Immunology Experts - years of experience monitoring antibody and T-Cell response in mucosa

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Cells and Tissues

Price on request
  • Whole Blood Processing (PBMCs, Serum, Plasma)
  • Tissue Processing (Splenocytes, bone marrow aspirate, tumor, lymph node, gut, rectal, vaginal)
  • Mucosal Immunology Experts - years of experience monitoring antibody and T-Cell response in mucosa
  • Whole Blood Processing (PBMCs, Serum, Plasma)
  • Tissue Processing (Splenocytes, bone marrow aspirate, tumor, lymph node, gut, rectal, vaginal)
  • Mucosal Immunology Experts - years of experience monitoring antibody and T-Cell response in mucosa
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Biomarkers

Price on request

Assay development and fit-for-purpose analytical validation
Assay optimization and prototyping for future diagnostic tests
Sample testing for preclinical and clinical studies
ELISA / Luminex, SIMOA, Aushon, MSD

Assay development and fit-for-purpose analytical validation
Assay optimization and prototyping for future diagnostic tests
Sample testing for preclinical and clinical studies
ELISA / Luminex, SIMOA, Aushon, MSD

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Nucleic Acid Services

Price on request

Biodistribution Studies (PCR)
PK Studies (gene therapies)

Biodistribution Studies (PCR)
PK Studies (gene therapies)

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Protein Quantification

Price on request

Assay optimization, characterization, verification and validation services available.
ELISA / MSD / Luminex / SIMOA / Auschon

Assay optimization, characterization, verification and validation services available.
ELISA / MSD / Luminex / SIMOA / Auschon

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Pharmacology & Toxicology

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Cytometry

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Formulation Services

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DNA Services

Price on request

Biodistribution Studies (PCR)
PK Studies (gene therapies)

Biodistribution Studies (PCR)
PK Studies (gene therapies)

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Virology Services

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Clinical Research

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Clinical Laboratory Services

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ISO 9001:2015 Accredited
GCLP Certified
EQUAPOL (External Quality Assurance Program Oversight Laboratory) Monitored

ISO 9001:2015 Accredited
GCLP Certified
EQUAPOL (External Quality Assurance Program Oversight Laboratory) Monitored

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Human Immunology CNS/Neurology Immuno-Oncology

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Mutagenesis

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Drug Discovery

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Protein Services

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Manufacturing Services

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Biospecimens

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Biology

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Protein Expression Visualization

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Immunostaining

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Cell-Based Assays

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Drug Discovery & Development

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Antibody Services

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Mammalian Models

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Animal Models and Studies

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Cell Lines

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Cell Viability & Proliferation Assays

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Clinical Hematology

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Biochemistry & Molecular Biology

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Flow Cytometry Data Analysis

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Bioanalytical Assays

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Bioanalytical Assays Services

Bioanalytical Assays Services

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Pharmacology

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Pharmacology Services

Pharmacology Services

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Noah Cockroft

Sales Manager
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Beth Zielinski-Habershaw

Sales Manager

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