6r1p3c7st6llznveknxq adesis

Adesis, Inc.

No Reviews Yet
No Completed Orders
New Castle, Delaware, US

About Adesis, Inc.

Adesis offers the fastest and highest quality custom synthesis and small molecule manufacturing services.

We are a contract research organization (CRO) supporting the pharmaceutical and biopharmaceutical industry, biomaterials, and catalysts industry. It specializes in organic and organometallic synthesis, in milligrams to multi-kilogram quantities. Adesis has a business model of providing clients with organic chemistry services in three areas: early stage research, scale up and development, and specialty manufacturing. We have been successful for over 20 years by taking a different approach than other CRO’s. Our leadership team of scientists implemented a simple approach: hire talented chemists with exceptional work ethics, integrity, versatility, and a commitment to deliver the project/material to our client.

 

On-site Specialized Equipment:
2 x 3000 L Liquid nitrogen tanks to supply high purity N2 for analytical and inert atmosphere for reaction safety.
Reactors:
• 2 L Chemglass glass jacketed, Huber Ministat 230 (-40-200C)

• 2 x 12 L Jacketed glass round-bottom (custom made by At-Mar)

• 1 x 20 L ChemGlass Glass Jacketed, Huber chiller/heater (-50 to 250C)

• 3 x 100 L ChemGlass Glass Jacketed, Huber chiller/heater (-50 to 250C)

• 300 mL, 500 mL, and 1 L ChemGlass jacketed reactors

Process Development Equipment:
• EasyMax 102

   o Advanced synthesis work station enabling the optimization of synthetic routes

   o Capable of optimizing reaction conditions on volumes between 0.5 – 100 mL

   o Temperature range of -40 °C – 180 °C

 

• Biotage Endeavor o Catalyst screening system capable of optimization of pressurized reactions

   o Pressure range of 50 – 500 psi

   o Temperature range of ambient to 200 °C

• PolyBLOCK

   o Flexible and Compact Multi-Reactor System

   o Eight independent reaction zones

   o Temperature range of -60 °C to 225 °C

• Thermal screening unit (TSU)

• Olympus Microscope

• X-Ray powder diffractometer (XRPD)

Distillation Equipment:
• Molecular-film Distillation o Capable on small scale through kilo scale depending on type of compound

• Fractional Distillation

   o Capable of operation on kilo-scale

• Kugelrohr distillation

Chromatography Equipment:
• Automated Chromatography systems:

   o Capable of mg - ~100 g during a single purification

   o Biotage chromatography system

   o 7 x Buchi chromatography system

▪ Capable with ELS detector

   o 11 x Interchim automated chromatography systems

   o Interchim preparative chromatography system

   o Teledyne Isco AccuPrep preparative chromatography system

• Biotage Flash Chromatography systems (for large scale purifications)

• Proprietary chromatography systems (for large scale purifications)

• Preparative chiral separations (via third-party arrangements)

• Glass columns for chromatography ranging in size from small scale to industrial size

Specialized Equipment:
• Hydrogenator and Parr reactors (20 mL, 100 mL, 250 mL, 2 L, and 20 L)

   o Capable of up to 2000 psi at varying temperatures

   o Typical ranges: Approx. up to 200 psi and up to 150 °C

• Ozone Generator: up to 5 lb per day

• Automated microwave synthesizer (parallel synthesis format)

• Advion benchtop mass spec with TLC plate express

• Rayonet Photolyzer

• UV Lamps

• Lyophilizer

Sublimation Equipment:
• Sublimation / Zone refinement

   o 2 PVD sublimation units

▪ 100 mm and 200 mm diameters

   o 4 Thermcraft sublimation units

      ▪ 1, 3, 4, and 6 inch diameters

   o Temperatures reaching over 500 °C

   o Mg to 400 g scale

   o Edwards rough pumps

   o Leybold turbo pumps – reaching pressures as low as 1 x 10-6 torr o Dry ice traps & particle traps


Miscellaneous Equipment:
• Flow cytometer

• Soxhlet Extraction

• ChillstatTM chillers

• Syringe pump

• Buchi rotary evaporators w/pumps (ranging in size from bench top to stand-alone, industrial size)

• Preparatory TLC plates for small scale, precise, purification

• Dean-Stark distillation apparatus

• Schlenk glassware for air-sensitive chemistry

• Glove-box for air-sensitive chemistry

• Extraction and addition funnels, small scale through industrial scale

• Vacuum/convection ovens

On-Site Analytical Capabilities:
• Multi-nuclei 300 MHz and 400 MHz NMRs with heteronuclear capabilities

• HPLC:

   o 2 x Agilent HPLC 1100

   o Waters Aquity Arc

       ▪ Both HPLC and UPLC Modes available

       ▪ Pressure up to 800 bar

       ▪ Normal phase

   o Agilent 1260 Infinity II

   o Shimadzu Prominence

   o Preparative HPLC – Teledyne Isco AccqPrep HP125

       ▪ Equipped with autosampler

• HPLC-MS:

   o Agilent HPLC 1260 Infinity with Agilent 6150 MSD (Mass selective detector)

       ▪ Operating pressure up to 600 bar

       ▪ Mass range to 1200 mass units

   o 4 x Agilent HPLC 1260 Infinity II with Agilent G6125B MSD

       ▪ Operating pressure up to 600 bar

       ▪ Mass range to 2000 mass units

       ▪ ELS detection capability

   o Waters Aquity Arc with Qda MSD

       ▪ Both HPLC and UPLC Modes available

       ▪ Pressure up to 800 bar

       ▪ Reverse phase

       ▪ Charged Aerosol Detection (CAD) – ThermoScientific CoronaVeo

• For detection of molecules without a chromophore

   o 2 x Agilent 1260 Infinity

• UPLC-MS:

   o 3 x Shimadzu Nexera X2 (LCMS-2020 MSD)

       ▪ Mass range to 2000 mass units

• 2 x Shimadzu Nexera X2 UPLC o Used to run multiple columns and solvent systems to scout methods

• GC:

   o Agilent 7890A GC with Agilent 5975C MSD

   o Shimadzu GC 2010 o GC – Agilent 6850

   o Additional GC-MS on order

• GPC – Waters e2695 separation module with 2414 RI detector

• Hydrogen Generator #1 & #2 – Peak Scientific Precision Hydrogen 200 cc

• Hydrogen Generator #3 – LNI Swissgas HG Pro

• Karl Fischer Titrator - Metrohm 784 KFP Titrino

• Acid/Base Titrator - Metrohm 888 Titrando

• FT-IR – Perken Elmer Spectrum Two o KBr pellets and liquid sample cards

• UV/Vis spectrophotometer – ThermoScientific Genesys 10S o 10 mm path length cells o Quartz cells available

• Polarimeter – Perken Elmer Model 343

   o 1 mL and 10 mL sample cells

• TGA – TA Instruments 951

• Melting Point:

   o Buchi M565, Equipped with playback

   o Buchi B545

• Analytical balances:

   o Mettler Toledo New Classic MS

       ▪ 5 decimal places, reads grams and milligrams

o Sartorious Quintix123-IS

       ▪ 5 decimal places

o Fisher SLF5000

Our Services (7)


ic

Medicinal Chemistry Consulting

Price on request
Request a quote for more information about this service.

ic

Drug Discovery

Price on request

Typically these projects have more of a research component, which many clients preferably undertake in Full time equivalents (FTEs), which are committed full time to the sponsor. FTE-based projects are quoted on time and materials, with back-charge of raw materials.

These are research oriented projects and/or difficult projects, where the substantial technical risks preclude quoting a fixed price. FTE projects generally involve smaller amounts of material (500 mg to 50 grams). Additional benefits for contracting full time equivalents (FTE) versus contracting multiple one-off type projects include:

Reliable Capacity
FTE contracts provide our clients consistent and reliable laboratory capacity. We have the attribute of personnel skillset redundancies, which allow for additional personnel to be incorporated into a project with minimum productivity loss.
Project Execution Facilitation
Projects may be initiated immediately when the chemistry is provided – there is no time lapse for proposal writing and contract approval process.
Flexibility and Responsiveness
The data-driven dynamics of the discovery environment often necessitates changes in goals. For example, late-breaking biological or physicochemical data on an investigational molecule will prompt its deprioritization in favor of another lead. Consequently, the scale-up synthesis of a target molecule may need to be modified mid-stream or suspended. The FTE approach allows for projects to change without the need to adjust a work order.

On-site Specialized Equipment:
2 x 3000 L Liquid nitrogen tanks to supply high purity N2 for analytical and inert atmosphere for reaction safety.
Reactors:
• 2 L Chemglass glass jacketed, Huber Ministat 230 (-40-200C) • 2 x 12 L Jacketed glass round-bottom (custom made by At-Mar) • 1 x 20 L ChemGlass Glass Jacketed, Huber chiller/heater (-50 to 250C) • 3 x 100 L ChemGlass Glass Jacketed, Huber chiller/heater (-50 to 250C) • 300 mL, 500 mL, and 1 L ChemGlass jacketed reactors

Process Development Equipment:
• EasyMax 102 o Advanced synthesis work station enabling the optimization of synthetic routes o Capable of optimizing reaction conditions on volumes between 0.5 – 100 mL o Temperature range of -40 °C – 180 °C • Biotage Endeavor o Catalyst screening system capable of optimization of pressurized reactions o Pressure range of 50 – 500 psi o Temperature range of ambient to 200 °C • PolyBLOCK o Flexible and Compact Multi-Reactor System o Eight independent reaction zones o Temperature range of -60 °C to 225 °C • Thermal screening unit (TSU) • Olympus Microscope • X-Ray powder diffractometer (XRPD)

Distillation Equipment:
• Molecular-film Distillation o Capable on small scale through kilo scale depending on type of compound • Fractional Distillation o Capable of operation on kilo-scale • Kugelrohr distillation

Chromatography Equipment:
• Automated Chromatography systems: o Capable of mg - ~100 g during a single purification o Biotage chromatography system
o 7 x Buchi chromatography system ▪ Capable with ELS detector o 11 x Interchim automated chromatography systems o Interchim preparative chromatography system o Teledyne Isco AccuPrep preparative chromatography system • Biotage Flash Chromatography systems (for large scale purifications) • Proprietary chromatography systems (for large scale purifications) • Preparative chiral separations (via third-party arrangements) • Glass columns for chromatography ranging in size from small scale to industrial size

Specialized Equipment:
• Hydrogenator and Parr reactors (20 mL, 100 mL, 250 mL, 2 L, and 20 L) o Capable of up to 2000 psi at varying temperatures o Typical ranges: Approx. up to 200 psi and up to 150 °C • Ozone Generator: up to 5 lb per day • Automated microwave synthesizer (parallel synthesis format) • Advion benchtop mass spec with TLC plate express • Rayonet Photolyzer • UV Lamps • Lyophilizer
Sublimation Equipment:
• Sublimation / Zone refinement o 2 PVD sublimation units ▪ 100 mm and 200 mm diameters o 4 Thermcraft sublimation units ▪ 1, 3, 4, and 6 inch diameters o Temperatures reaching over 500 °C o Mg to 400 g scale o Edwards rough pumps o Leybold turbo pumps – reaching pressures as low as 1 x 10-6 torr o Dry ice traps & particle traps

Miscellaneous Equipment:
• Flow cytometer • Soxhlet Extraction • ChillstatTM chillers • Syringe pump • Buchi rotary evaporators w/pumps (ranging in size from bench top to stand-alone, industrial size)
• Preparatory TLC plates for small scale, precise, purification • Dean-Stark distillation apparatus • Schlenk glassware for air-sensitive chemistry • Glove-box for air-sensitive chemistry • Extraction and addition funnels, small scale through industrial scale • Vacuum/convection ovens

On-Site Analytical Capabilities:
• Multi-nuclei 300 MHz and 400 MHz NMRs with heteronuclear capabilities • HPLC: o 2 x Agilent HPLC 1100 o Waters Aquity Arc ▪ Both HPLC and UPLC Modes available ▪ Pressure up to 800 bar ▪ Normal phase o Agilent 1260 Infinity II o Shimadzu Prominence o Preparative HPLC – Teledyne Isco AccqPrep HP125 ▪ Equipped with autosampler • HPLC-MS: o Agilent HPLC 1260 Infinity with Agilent 6150 MSD (Mass selective detector) ▪ Operating pressure up to 600 bar ▪ Mass range to 1200 mass units o 4 x Agilent HPLC 1260 Infinity II with Agilent G6125B MSD ▪ Operating pressure up to 600 bar ▪ Mass range to 2000 mass units ▪ ELS detection capability o Waters Aquity Arc with Qda MSD ▪ Both HPLC and UPLC Modes available ▪ Pressure up to 800 bar ▪ Reverse phase ▪ Charged Aerosol Detection (CAD) – ThermoScientific CoronaVeo • For detection of molecules without a chromophore o 2 x Agilent 1260 Infinity • UPLC-MS: o 3 x Shimadzu Nexera X2 (LCMS-2020 MSD) ▪ Mass range to 2000 mass units • 2 x Shimadzu Nexera X2 UPLC o Used to run multiple columns and solvent systems to scout methods

• GC: o Agilent 7890A GC with Agilent 5975C MSD
o Shimadzu GC 2010 o GC – Agilent 6850 o Additional GC-MS on order • GPC – Waters e2695 separation module with 2414 RI detector • Hydrogen Generator #1 & #2 – Peak Scientific Precision Hydrogen 200 cc • Hydrogen Generator #3 – LNI Swissgas HG Pro • Karl Fischer Titrator - Metrohm 784 KFP Titrino • Acid/Base Titrator - Metrohm 888 Titrando • FT-IR – Perken Elmer Spectrum Two o KBr pellets and liquid sample cards • UV/Vis spectrophotometer – ThermoScientific Genesys 10S o 10 mm path length cells o Quartz cells available • Polarimeter – Perken Elmer Model 343 o 1 mL and 10 mL sample cells • TGA – TA Instruments 951 • Melting Point: o Buchi M565 ▪ Equipped with playback o Buchi B545 • Analytical balances: o Mettler Toledo New Classic MS ▪ 5 decimal places, reads grams and milligrams o Sartorious Quintix123-IS ▪ 5 decimal places o Fisher SLF5000


ic

Chemical Synthesis

Price on request

Adesis has a long record of success in performing expeditious synthesis campaigns, often multi-steps, under tight customer timelines. Our success is enabled through seamless execution of robust chemistries, which limit risks, in tandem with research and logistical operations.

Such projects are often defined as Single Compound (One-offs; Fee-for-Service) projects and are bid at a guaranteed fixed price for labor. Raw materials may either be included in the fixed price or back-charged at cost. The decision to back-charge raw materials depends on the anticipated reliability of the synthesis procedure provided, as well as scalability. One-off projects are typically projects involving large quantities of material.

Drug Discovery Good Laboratory Practice gram kilogram all

ic

Chemistry and Materials

Price on request
Request a quote for more information about this service.

ic

Process and Scale-Up Chemistry

Price on request

On-site Specialized Equipment:
2 x 3000 L Liquid nitrogen tanks to supply high purity N2 for analytical and inert atmosphere for reaction safety.
Reactors:
• 2 L Chemglass glass jacketed, Huber Ministat 230 (-40-200C)

• 2 x 12 L Jacketed glass round-bottom (custom made by At-Mar)

• 1 x 20 L ChemGlass Glass Jacketed, Huber chiller/heater (-50 to 250C)

• 3 x 100 L ChemGlass Glass Jacketed, Huber chiller/heater (-50 to 250C)

• 300 mL, 500 mL, and 1 L ChemGlass jacketed reactors

Process Development Equipment:
• EasyMax 102

   o Advanced synthesis work station enabling the optimization of synthetic routes

   o Capable of optimizing reaction conditions on volumes between 0.5 – 100 mL

   o Temperature range of -40 °C – 180 °C

 

• Biotage Endeavor o Catalyst screening system capable of optimization of pressurized reactions

   o Pressure range of 50 – 500 psi

   o Temperature range of ambient to 200 °C

• PolyBLOCK

   o Flexible and Compact Multi-Reactor System

   o Eight independent reaction zones

   o Temperature range of -60 °C to 225 °C

• Thermal screening unit (TSU)

• Olympus Microscope

• X-Ray powder diffractometer (XRPD)

Distillation Equipment:
• Molecular-film Distillation o Capable on small scale through kilo scale depending on type of compound

• Fractional Distillation

   o Capable of operation on kilo-scale

• Kugelrohr distillation

Chromatography Equipment:
• Automated Chromatography systems:

   o Capable of mg - ~100 g during a single purification

   o Biotage chromatography system

   o 7 x Buchi chromatography system

▪ Capable with ELS detector

   o 11 x Interchim automated chromatography systems

   o Interchim preparative chromatography system

   o Teledyne Isco AccuPrep preparative chromatography system

• Biotage Flash Chromatography systems (for large scale purifications)

• Proprietary chromatography systems (for large scale purifications)

• Preparative chiral separations (via third-party arrangements)

• Glass columns for chromatography ranging in size from small scale to industrial size

Specialized Equipment:
• Hydrogenator and Parr reactors (20 mL, 100 mL, 250 mL, 2 L, and 20 L)

   o Capable of up to 2000 psi at varying temperatures

   o Typical ranges: Approx. up to 200 psi and up to 150 °C

• Ozone Generator: up to 5 lb per day

• Automated microwave synthesizer (parallel synthesis format)

• Advion benchtop mass spec with TLC plate express

• Rayonet Photolyzer

• UV Lamps

• Lyophilizer

Sublimation Equipment:
• Sublimation / Zone refinement

   o 2 PVD sublimation units

▪ 100 mm and 200 mm diameters

   o 4 Thermcraft sublimation units

      ▪ 1, 3, 4, and 6 inch diameters

   o Temperatures reaching over 500 °C

   o Mg to 400 g scale

   o Edwards rough pumps

   o Leybold turbo pumps – reaching pressures as low as 1 x 10-6 torr o Dry ice traps & particle traps


Miscellaneous Equipment:
• Flow cytometer

• Soxhlet Extraction

• ChillstatTM chillers

• Syringe pump

• Buchi rotary evaporators w/pumps (ranging in size from bench top to stand-alone, industrial size)

• Preparatory TLC plates for small scale, precise, purification

• Dean-Stark distillation apparatus

• Schlenk glassware for air-sensitive chemistry

• Glove-box for air-sensitive chemistry

• Extraction and addition funnels, small scale through industrial scale

• Vacuum/convection ovens

On-Site Analytical Capabilities:
• Multi-nuclei 300 MHz and 400 MHz NMRs with heteronuclear capabilities

• HPLC:

   o 2 x Agilent HPLC 1100

   o Waters Aquity Arc

       ▪ Both HPLC and UPLC Modes available

       ▪ Pressure up to 800 bar

       ▪ Normal phase

   o Agilent 1260 Infinity II

   o Shimadzu Prominence

   o Preparative HPLC – Teledyne Isco AccqPrep HP125

       ▪ Equipped with autosampler

• HPLC-MS:

   o Agilent HPLC 1260 Infinity with Agilent 6150 MSD (Mass selective detector)

       ▪ Operating pressure up to 600 bar

       ▪ Mass range to 1200 mass units

   o 4 x Agilent HPLC 1260 Infinity II with Agilent G6125B MSD

       ▪ Operating pressure up to 600 bar

       ▪ Mass range to 2000 mass units

       ▪ ELS detection capability

   o Waters Aquity Arc with Qda MSD

       ▪ Both HPLC and UPLC Modes available

       ▪ Pressure up to 800 bar

       ▪ Reverse phase

       ▪ Charged Aerosol Detection (CAD) – ThermoScientific CoronaVeo

• For detection of molecules without a chromophore

   o 2 x Agilent 1260 Infinity

• UPLC-MS:

   o 3 x Shimadzu Nexera X2 (LCMS-2020 MSD)

       ▪ Mass range to 2000 mass units

• 2 x Shimadzu Nexera X2 UPLC o Used to run multiple columns and solvent systems to scout methods

• GC:

   o Agilent 7890A GC with Agilent 5975C MSD

   o Shimadzu GC 2010 o GC – Agilent 6850

   o Additional GC-MS on order

• GPC – Waters e2695 separation module with 2414 RI detector

• Hydrogen Generator #1 & #2 – Peak Scientific Precision Hydrogen 200 cc

• Hydrogen Generator #3 – LNI Swissgas HG Pro

• Karl Fischer Titrator - Metrohm 784 KFP Titrino

• Acid/Base Titrator - Metrohm 888 Titrando

• FT-IR – Perken Elmer Spectrum Two o KBr pellets and liquid sample cards

• UV/Vis spectrophotometer – ThermoScientific Genesys 10S o 10 mm path length cells o Quartz cells available

• Polarimeter – Perken Elmer Model 343

   o 1 mL and 10 mL sample cells

• TGA – TA Instruments 951

• Melting Point:

   o Buchi M565, Equipped with playback

   o Buchi B545

• Analytical balances:

   o Mettler Toledo New Classic MS

       ▪ 5 decimal places, reads grams and milligrams

o Sartorious Quintix123-IS

       ▪ 5 decimal places

o Fisher SLF5000


ic

Experimental Services

Price on request
Request a quote for more information about this service.

ic

Formulation Services

Price on request
Request a quote for more information about this service.

Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.

FileType/PDF Created with Sketch. Adesis_EquipmentList_18092019.pdf

Click to Download

FileType/PDF Created with Sketch. ADESIS-trifold-05-14-19.pdf

Click to Download

Adesis, Inc. has not received any reviews.

Adesis, Inc. has not received any endorsements.