Active Motif is the industry leader in developing and delivering innovative tools to enable epigenetics and gene regulation research. We are committed to providing the highest quality products and superior service & support to serve the life science, clinical and pharmaceutical/drug discovery communities. Whether you are an expert in the field of epigenetics or a researcher interested in integrating epigenetics research into your studies, Active Motif offers a comprehensive portfolio of epigenetics-related products and services and the support of our team of epigenetic experts to provide complete and innovative solutions to tackle your scientific inquiries.
Active Motif performs custom ChIP-qPCR assays to provide quantitative data on transcription factor binding and histone modification occupancy. Our Epigenetic Services team performs thousands of ChIP reactions every year. In order to make all of our experiments comparable and establish criteria for success, we have devised a unique normalization strategy. This normalization strategy, along with special attention dedicated to evaluating signal intensity and background levels, results in the highest quality ChIP data available.
The ChIP-qPCR Service includes:
Customers submit frozen tissues or cell pellets, then we:
Customers submit fixed cell pellets or frozen tissues, then we:
ATAC-Seq is based on transposase-mediated insertion of sequencing primers into open chromatin regions. This assay provides genome-wide profiles of open and accessible regions of chromatin that are indicative of active regulatory regions.
Why study Open Chromatin?
ATAC-Seq can be a good alternative to ChIP-Seq if it is unknown whether epigenetics plays a role in the response of your cell system, if it is unclear which histone modification is the most important to study using ChIP-Seq or when cell numbers are limited.
The ATAC-Seq assay includes;
Active Motif’s services team is the only group routinely generating ATAC-Seq data from tissues. Active Motif will accept the following sample types for this service:
RNA-Seq is a powerful tool for measuring gene expression changes with many applications including:
Active Motif provides a comprehensive RNA-Seq service that includes everything from isolation of RNA to data analysis. Combine our worldwide leading ChIP-Seq services with RNA-Seq to gain an even greater understanding of your biological system.
Reduced Representation Bisulfite Sequencing (RRBS) is a method that facilitates the identification of differentially methylated regions by providing DNA methylation data at single base pair resolution on greater than 4 million CpGs. More cost effective than Whole Genome Bisulfite Sequencing and with greater coverage than bead array based DNA methylation platforms, RRBS is an ideal platform to profile DNA methylation across samples.
New technologies and high-throughput approaches have created exciting opportunities at the intersection of genomics and immunology. Using next-gen sequencing, Active Motif has developed a novel method to profile the complete antibody repertoire of an organism. We have also created new gene assembly methods to convert immune repertoire sequence information into large collections of full IgG antibodies that can be screened for function.
RIME (Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins) is a recently developed technique ideally suited for the identification of transcriptional co-factors and chromatin associated proteins.
The RIME Service includes:
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