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Accurus Biosciences

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Richmond, California, US

About Accurus Biosciences

Accurus Biosciences is a young biomedical contract research service company based in the San Francisco Bay Area. The company has expertise in therapeutic antibody discovery, antibody and protein engineering, recombinant protein expression, stable cell line generation and cell based assay development. Currently we provide services in hybridoma antibody generation, antibody humanization, recombinant protein and antibody production, stable cell line generation and cell based assays.

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Our Services (15)


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Therapeutic Monoclonal Antibody (mAb) Development

Starting at $50,000.00 per study

Accurus Biosciences provides a complete suite of services for the discovery of therapeutic antibody leads. We employ a highly efficient mouse hybridoma antibody generation and screening process, coupled with a computer aided antibody humanization process to select high affinity therapeutic antibodies with desired functions and properties in a very competitive timeline.

Our advantages include:

- Proprietary antigen designs and multiple routes of immunization to boost immune responses in animals.

- Optimized and highly efficient hybridoma electrofusion process.

- High-throughput flow cytometry screening for monoclonal antibodies specific to cell surface receptor antigens.

- Functional screening of lead antibodies in complex bioassays.

- Generation of mAbs with high affinities and desired functional properties.

- Proven track record of success: generated therapeutic lead antibodies to CD47, CLDN18.2, CSF-1R, B7-H3, B7-H4, LAG-3, CD40, FOLR1, VISTA etc.



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Plasmid DNA Preparation

Starting at $150.00 per prep

Plasmid mini-; midi-; maxi-; mega or giga preps:

- Customer to provide plasmid DNA sample or E. coli culture

- Purified plasmid DNA ready for in vitro mammalian transient or stable expression

- Turn-around time: 3-5 days

Plasmid midi-; maxi-, mega or giga preps (Low endotoxin):

- Customer to provide plasmid DNA sample or E. coli culture

- Purified plasmid DNA ready for DNA immunizations & in vivo expression

- Turn-around time: 3-5 days


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Protein Engineering/Directed Evolution

Starting at $3,000.00 per study

Accurus Biosciences provides various protein/antibody engineering services to our academic and industrial customers. We use a wide variety of methodologies to improve the function, expression and stability of your recombinant protein and antibody. Here is a list of services we can provide:

- Protein Fc fusions

- Protein albumin fusions

- Protein mutagenesis

- Antibody-protein fusions

- Protein epitope tagging


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Antibody Engineering

Starting at $3,000.00 per study

Accurus Biosciences provides various protein/antibody engineering services to our academic and industrial customers. We use a wide variety of methodologies to improve the function, expression and stability of your recombinant protein and antibody. Here is a list of services we can provide:

- Antibody effector function optimization:

- Antibody glycosylation modifications:

- Antibody humanization:

     - We choose the optimal human antibody framework sequences for your rodent or rabbit antibodies based on our proprietary algorithms and our deep knowledge in antibody structure and function relationship.

     - We couple the humanization process with antibody expression and stability analysis so the final antibodies will have high expression and stability.


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Site-Directed Mutagenesis

Price on request
  • Customer to provide gene template and mutant sequences
  • Confirmation of mutation site by sequencing
  • Turn-around time: 7-10 days


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PCR

Price on request
  • Customer to provide PCR templates, primer sequences and destination vector
  • End-sequence confirmation
  • Turn-around time: 5-7 days


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DNA Subcloning

Price on request
  • Customer to provide target genes in a vector or as PCR products and the destination vectors
  • End-sequence confirmation
  • Turn-around time: 5-7 days


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Recombinant Protein Expression

Starting at $3,000.00 per prep

- We use a variety of mammalian expression host cells, including CHO-S, CHO-K1, HEK293T and HEK293E.

- Our proprietary production cell lines and expression vector systems enable high levels of protein production in both transient and stable settings.

- We ensure high quality of our purified proteins and antibodies. Customers have the option to test the conditioned media before purification.

- Purity > 95% as determined by SDS-PAGE or HPLC.

- Endotoxin < 1 EU/mg by LAL assay.

- Optimized protein formulation buffer.

- Fast turn-around time: 3-6 weeks for 1-100 mgs of protein or antibodies


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Recombinant Antibody Production

Starting at $3,000.00 per prep

- We use a variety of mammalian expression host cells, including CHO-S and HEK293E.

- Our proprietary production cell lines and expression vector systems enable high levels of protein production in both transient and stable settings.

- Customers have the option to test the conditioned media before purification.

- We ensure high quality of our purified proteins and antibodies. 

- Purity > 95% as determined by SDS-PAGE or HPLC

- Endotoxin < 1 EU/mg

- Optimized antibody formulation buffer

- Fast turn-around time: 3-6 weeks for 1-100 mgs of protein or antibodies


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Cell Line Generation

Starting at $5,000.00 per cell line
  • Our proprietary expression vector systems enable high level protein production as well as receptor cell surface expression.
  • We use a variety of common mammalian expression hosts, including CHO-S, 293E, 293F, 293T, Ba/F3 and MDCKII.
  • We also use a wide variety of tumor cell lines requested by our customers such as NIH3T3, LNcap, CT26, THP-1 and MDA-MB-231.
  • We ensure the quality of our stable cell lines.
    • Protein production or cell surface expression levels stable for at least 30 days in culture
    • One log shift in FACS analysis, if expressing receptors on cell surface

Timelines: 2-3 weeks for stable pools and 4-5 weeks for stable cell lines


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Custom Cell-Based Assay Development

Price on request
Request a quote for more information about this service.

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Cell Proliferation Assays

Price on request
Request a quote for more information about this service.

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Apoptosis Assays

Price on request
Request a quote for more information about this service.

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Protein Production

Price on request
Request a quote for more information about this service.

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Cytometry

Starting at $1,000.00 per study

We provide custom flow cytometry analysis for our clients.  We currently have one BD FACS Caliber for multicolor flow cytometry analysis of your samples and one ThermoFisher Attune NxT Cytometer for 96 well based high throughput FACS analysis. 


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