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Absorption Systems

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4 Orders Completed
Exton, Pennsylvania, US

About Absorption Systems

Founded: 1996 Type: Privately Held Size: 51-200 employees

Absorption Systems is a full service nonclinical CRO developing innovative services and solutions for the pharmaceutical, biotech, medical device and regenerative medicine industry. Our services include research and testing for small molecules, large molecules, biologics, medical device and cell and gene... Show more »

Absorption Systems is a full service nonclinical CRO developing innovative services and solutions for the pharmaceutical, biotech, medical device and regenerative medicine industry. Our services include research and testing for small molecules, large molecules, biologics, medical device and cell and gene therapy products. The company's mission is to continually develop innovative research tools that can be used to accurately predict human outcomes or to explain unanticipated outcomes when they occur. The company's facilities are strategically located in Philadelphia, San Diego, Boston and Panama, servicing hundreds of customers throughout the world. Our focus is to maintain accuracy, timelines, and reliability at every stage of development. For more information on the company's comprehensive contract services and applied research programs, please visit absorption.com.

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Our Services (115)


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PCR

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ELISA

Enzyme-linked immunosorbent assay
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Immunoassays

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In vitro Drug Efficacy Testing

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Potency Assays

Potency Assays

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Gene Therapy Development

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Large Molecule Bioanalysis

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Drug Transporter Assays

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Dermal Pharmacology & Efficacy Studies

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Dermal Toxicity Studies

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Cell Permeability Assay

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In Vitro Permeation Testing

In Vitro Permeation Testing

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Drug Release Studies/In Vitro Release Testing (IVRT)

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Ocular Toxicology

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Our formulations team can help identify and prepare dose vehicles that are appropriate for short or long-term toxicology studies. Dosing and observations are handled by our expert staff with more than a decade’s experience in small and large animal studies (acute, subchronic, chronic, dose range finding, etc). Our in-house... Show more »

Our formulations team can help identify and prepare dose vehicles that are appropriate for short or long-term toxicology studies. Dosing and observations are handled by our expert staff with more than a decade’s experience in small and large animal studies (acute, subchronic, chronic, dose range finding, etc). Our in-house bioanlaytical capabilities (both non-GLP and GLP) enable us to oversee your project from beginning to end.
Services available:
Direct / Indirect Ophthalmoscopy
Slit-Lamp Biomicroscopy
Optical Coherence Tomography (OCT)
Fundus Photography
Fluorescein Angiography
Auto-Fluorescence
Indocyanine Green (ICG)
Pachymetry
Intraocular Pressure
Electroretinography (ERG, mfERG), VEP
Specular Microscopy
Ultrasound
Phacoemulsification
Vitrectomy
Cell Culture Room

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Medical Device Testing

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Absorption Systems offers a wide range of in vivo preclinical medical device testing services at our San Diego facility. Our goal is helping our clients attain successful 510(k) or PMA submissions. Our USDA-registered and NIH-assured, AAALAC-accredited GLP facility is also available for contract vivarium leasing and physician... Show more »

Absorption Systems offers a wide range of in vivo preclinical medical device testing services at our San Diego facility. Our goal is helping our clients attain successful 510(k) or PMA submissions. Our USDA-registered and NIH-assured, AAALAC-accredited GLP facility is also available for contract vivarium leasing and physician training sessions.

Overview of Services
In vivo, GLP and non-GLP
In-House IACUC
Research Protocols
Model Development
Feasibility Studies
Safety and Efficacy
Physician Training & Cadaver Studies
Histopathological Support
Bioanalytical Support
Vivarium Leasing
Surgical Suites

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Human Rabbit Guinea pig Sheep Goat Mouse Pig Rat Dog Minipig Hematology Cardiovascular Ophthalmology Metabolism and Endocrinology Musculoskeletal/Orthopedic Echocardiography Clinical chemistry Fluoroscopic Radiography Ultrasound & TEE Endoscope Blood Gas Measurement MRI CT & Micro-CT Biomarkers Show 24 more tags Show less

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Toxicology

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You can benefit from Absorption Systems’ integrated services for toxicology support. Preclinical toxicology and related safety studies are a pivotal part of the drug development life cycle, as they are needed to demonstrate that the test compound is safe, and at what doses, for administration to humans as part of clinical... Show more »

You can benefit from Absorption Systems’ integrated services for toxicology support. Preclinical toxicology and related safety studies are a pivotal part of the drug development life cycle, as they are needed to demonstrate that the test compound is safe, and at what doses, for administration to humans as part of clinical trials.
Dosing and observations are handled by our expert staff with more than a decade’s experience in small and large animal studies (acute, subchronic, chronic, dose range finding, etc). Our in-house bioanlaytical capabilities (both non-GLP and GLP) enable us to oversee your project from beginning to end.

Dose Routes

  • Intravenous
  • Oral
  • Intraperitoneal
  • Sublingual
  • Buccal
  • Transdermal
  • Intraduodenal
  • Subcutaneous
  • Intracolonic
  • Intramuscular
  • Intratracheal
  • Ocular

Dose Vehicle Development & Evaluation:

  • Excipient Selection
  • API – Compatibility
  • Vehicle – Suitability
  • Stability (dose vehicle)
  • Artificial Fluids Interactions
  • Simulated (gastric and intestinal fluids)
  • Phosphate-buffered Saline
  • Albumin Solution
  • In Vivo Performance Characterization
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In vivo Bioavailability/Bioequivalence Studies

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In vivo Percutaneous Absorption Studies

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We offer various surgically ported animal models to help with formulation assessment in addition to the standard rodent, canine and non-human primate models for oral and intravenous dosing. These include rats, dogs, and mini-pigs fitted with intestinal cannulas implanted at various sites for dosing solutions or suspensions, as... Show more »

We offer various surgically ported animal models to help with formulation assessment in addition to the standard rodent, canine and non-human primate models for oral and intravenous dosing. These include rats, dogs, and mini-pigs fitted with intestinal cannulas implanted at various sites for dosing solutions or suspensions, as well as dogs fitted with duodenal fistulas for dosing solids, semi-solids, capsules, and tablets directly into the duodenum. Several of these animal models are available routinely and other custom models can be prepared in line with customer needs.

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Animal Tissue Procurement

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CYP Inhibition Assay

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We incubate the test article, at either a single concentration or 7 concentrations, with a selective probe substrate and human liver microsomes. We monitor a specific metabolite and compare its rate of appearance with that of a solvent control to assess the extent of inhibition of a given CYP by each concentration of a test... Show more »

We incubate the test article, at either a single concentration or 7 concentrations, with a selective probe substrate and human liver microsomes. We monitor a specific metabolite and compare its rate of appearance with that of a solvent control to assess the extent of inhibition of a given CYP by each concentration of a test article. An IC50 can be determined when 7 concentrations are assessed. For reversible inhibition, an IC50 ≤ the plasma Cmax translates to a likely clinical DDI.
Time-dependent inhibition (TDI) is evaluated by quantifying the IC50 shift after pre-incubation of test article with liver microsomes +/- NADPH. Clinical correlation for a positive TDI score can then be determined by a follow-up in vitro measurement of KI and kinact. Comparison of KI and kinact to plasma Cmax can predict potential clinical DDIs due to TDI.

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Metabolite Identification

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We can perform isolation of a targeted metabolite from various in vitro and in vivo matrices followed by unambiguous structural elucidation using NMR. If isolation of metabolites is not feasible from biological matrices, we offer a complimentary approach – biomimetic oxidation.

Two-Tiered Approach

Preliminary

*... Show more »

We can perform isolation of a targeted metabolite from various in vitro and in vivo matrices followed by unambiguous structural elucidation using NMR. If isolation of metabolites is not feasible from biological matrices, we offer a complimentary approach – biomimetic oxidation.

Two-Tiered Approach

Preliminary

  • Report Expected Metabolites
    Comprehensive Analysis
  • Thorough metabolite detection
  • Structure Elucidation
    -Soft spot prioritization
  • Relative Abundance
  • Isolation of targeted metabolite(s)
    -Various matrices
    -Unambiguous structural elucidation using NMR
  • Biomimetic Oxidation
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Animal Bone Marrow

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Canine bone marrow collection

Canine bone marrow collection

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Plasma Protein Binding

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Plasma protein binding is critical in the early phases of drug development to determine the amount of a drug available for distribution throughout various organs and tissues in the body. In addition, these in vitro tests can predict the extent to which the drug will be bound to plasma proteins in vivo.

Plasma protein binding is critical in the early phases of drug development to determine the amount of a drug available for distribution throughout various organs and tissues in the body. In addition, these in vitro tests can predict the extent to which the drug will be bound to plasma proteins in vivo.

  • Low Protein Binding → High Free Drug Distribution
  • High Protein Binding → Low Free Drug Distribution
  • Protein bound drugs may have greater difficulty crossing cell membranes
  • Red Blood Cell / Plasma Partitioning
  • Multiple Species
  • Multiple Platform
    -Ultrafiltration
    - Equilibrium Dialysis
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Solubility and Dissolution Testing

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  • LogD by Shake Flask
  • Solubility by Shake Flask
  • Stability in Buffer
  • Stability in Gastric Fluids (FeSSIF, FaSSIF, SGF)
  • Stability in Plasma/Whole Blood
  • LogD by Shake Flask
  • Solubility by Shake Flask
  • Stability in Buffer
  • Stability in Gastric Fluids (FeSSIF, FaSSIF, SGF)
  • Stability in Plasma/Whole Blood
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Product Stability Testing

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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We offer an extensive range of preclinical animal models for drug discovery and development, both at its own sites and through access to preferred providers.

Pre-approved protocols for:

  • Intravenous
  • Intraperitoneal
  • Buccal
  • Intraperitoneal
  • Ocular
  • Oral
  • Sublingual
  • Topical
  • Subcutaneous
  • Intracheal

We offer an extensive range of preclinical animal models for drug discovery and development, both at its own sites and through access to preferred providers.

Pre-approved protocols for:

  • Intravenous
  • Intraperitoneal
  • Buccal
  • Intraperitoneal
  • Ocular
  • Oral
  • Sublingual
  • Topical
  • Subcutaneous
  • Intracheal
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RNAi Technology Development

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Contract Services Directory

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Radiography

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Preclinical Study Design

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Animal Model in vivo Analyses

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Nonclinical Research

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In vitro Metabolic Stability Assays

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Mass Spectrometry

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Hit to Lead and Lead Optimization

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High Throughput Screening (HTS)

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Pharmaceutical Formulation

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Feasibility Studies

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Drug Development

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Contract Research

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In vitro Percutaneous Absorption Studies

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The In Vitro Dissolution Absorption System (IDASTM) combines traditional dissolution testing with a means to determine and quantify interactions with a bio-relevant membrane. IDAS provides the ability to evaluate absorption, permeation, accumulation, biomarker regulation and metabolism, as well as the ability to test a... Show more »

The In Vitro Dissolution Absorption System (IDASTM) combines traditional dissolution testing with a means to determine and quantify interactions with a bio-relevant membrane. IDAS provides the ability to evaluate absorption, permeation, accumulation, biomarker regulation and metabolism, as well as the ability to test a finished dosage form from a tablet, capsule to suspension. The characterized and validated system allows for multiple dissolution media and drug products from all BCS classes.

Applications:

Evaluate Formulations – Bioequivalence, Post Approval Changes, 505(b)(2) Formulations
Evaluate Food Effects
Evaluate Locally Acting GI Products

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Permeation Biomarker regulation Toxicology

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Biopharmaceutical Development

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Biopharmaceutical Process Development

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Biological Testing

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Bioanalytical Analysis LC/MS/MS

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Animal Model Housing and Maintenance

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Assay Development

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Analytical Chemistry Services

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Time Dependent Study

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Solute-Linked Carrier (SLC) Transporter Inhibition Assays

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UDP-Glucuronosyltransferases (UGT) Assays

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Nucleoside Transporter Assays

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Glucose Transporter Assays

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Organic Ion Transporter Assays

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Peptide Transporter Assays

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Amino Acid Transporter Assays

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iTRAQ Protein Labeling

Isobaric Tags for Relative and Absolute Quantitation
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CYP Induction Assay

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Cyp Induction (1A2,2B6,3A4) EA409

Freshly isolated or cryopreserved hepatocytes are incubated with test article for 3 days.

Enzyme activity approach: Hepatocytes are then incubated with a selective probe substrate. Appearance of metabolite is compared to that of a control treatment (no test article) via LC-MS/MS in order to... Show more »

Cyp Induction (1A2,2B6,3A4) EA409

Freshly isolated or cryopreserved hepatocytes are incubated with test article for 3 days.

Enzyme activity approach: Hepatocytes are then incubated with a selective probe substrate. Appearance of metabolite is compared to that of a control treatment (no test article) via LC-MS/MS in order to assess the ability of the test article to induce a given CYP’s activity.
mRNA approach: mRNA is then isolated from the hepatocytes. cDNA is synthesized and used for qPCR to measure fold induction of CYP-specific mRNA. Comparison of treated cells to a control treatment (no test article) gives the article’s CYP induction potential.

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Ocular Absorption Studies

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Vaginal Permeability Studies

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HT ADME

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Histopathological Examination

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Protein Binding Ultrafiltration

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Small Molecule Bioanalysis

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In vivo Protein Binding Assays

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High Resolution Mass Spectrometry

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In vitro Bioavailability/Bioequivalence Studies

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In vivo Drug Efficacy Testing

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Accelerated Stability Testing

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Microsomal Stability Assay

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Chemistry and Materials

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Specialty Mass Spectrometry Methods

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Enzyme Assays

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Product Development, Testing, and Packaging

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Cell-Based Assays

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Clinical Research

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Clinical Laboratory Services

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Bioanalytical Assays

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Waters Xevo TQ-S
Thermo Scientific LTQ Orbitrap XL
AB Sciex 4000 QTRAP
AB Sciex API 4000
Waters Acquity UPLC
Leap CTC Analytics Autosamplers
Tomtec Quadra 96 robotic sample prep workstation
Conventional HPLC with UV detection
Fluorescence detectors
Scintillation counters

Waters Xevo TQ-S
Thermo Scientific LTQ Orbitrap XL
AB Sciex 4000 QTRAP
AB Sciex API 4000
Waters Acquity UPLC
Leap CTC Analytics Autosamplers
Tomtec Quadra 96 robotic sample prep workstation
Conventional HPLC with UV detection
Fluorescence detectors
Scintillation counters

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In vivo Toxicity Testing

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Safety Pharmacology

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Project Management

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Omics

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Animal Models and Studies

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Biology

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Biomolecular Interaction Analysis

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Pharmacology

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Pharmacology Services

Pharmacology Services

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Imaging & Spectroscopy

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Cells and Tissues

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Biochemical Assays

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Transporter & Cell Uptake Assays

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Bioanalysis

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Lead Identification and Validation

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Functional Human Tissue Assays

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Nucleic Acid Services

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Hit Identification

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Animal Biospecimens

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In vivo PK/PD Studies

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RNA Services

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Transferase Assays

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Manufacturing Services

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Spectroscopy

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In vitro ADME/DMPK Studies

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Proteomics

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Pharmacology & Toxicology

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In vitro Disease Models

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Drug Discovery

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Biospecimens

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Formulation Services

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Drug Discovery & Development

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Medical Devices & Diagnostics

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Medical Devices & Diagnostics Services

Medical Devices & Diagnostics Services

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Business Development Consulting

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Drug Absorption Studies

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Drug Absorption Studies Services

Drug Absorption Studies Services

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Biochemistry & Molecular Biology

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Metabolomics

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Metabolomics Services

Metabolomics Services

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Fluorescence Spectroscopy

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Toxicity Animal Models

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Protein-Protein Interaction Analysis

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  • Positive review for Tissue Processing:

    November 2018

    "The experience was overall positive. The platform was very easy to navigate."

Absorption Systems has not received any endorsements.