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Absolute Antibody

6 Orders Completed
Oxford, GB

About Absolute Antibody

Founded: 2012 Type: Privately Held Size: 11-50 employees

Absolute Antibody specialises in the sequencing, engineering, and recombinant production of antibodies. We offer antibody sequencing from cell lines such as hybridomas or immortalised B-cells as well as sequencing from purified antibody protein. Our engineering services include species/isotype/subtype switching, full humanization, generation of custom bispecifics, scFv, antibody fragments etc. If you can describe it, we can make it.
Using our serum-free transient expression platform we cater for milligram to gram scales with delivery in as little as 3 weeks. All of our services are royalty free.
We also have a catalog of recombinant reagents, including antibodies against common immune checkpoints and a range of research-grade biosimilars. All are available in any species and any isotype to suit your assay.
We're always excited to hear about new ideas, exciting innovations, and potential collaborations. Challenge us with your antibody problems - we'll see what we can do.

Standard sample shipment requirements:
Standard shipment on ice packs, dry ice on request

Our Services (9)


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Antibody Engineering

Price on request

At Absolute Antibody we have developed a proprietary cloning system to enable rapid reformatting of antibodies into almost any format. Our antibody engineering services include chimerization, humanization, isotype switching and the manufacturing of recombinant antibody fragments and bispecific antibodies.

Species, Isotype and Subtype switching
Change the constant domain of your antibody to Human, Mouse, Rabbit, Rat, Hamster, Goat, Sheep, Pig, Horse, Dog, Chicken, Fish, Platypus or a whole range on non-human Primates. Moreover, our in-house experts can determine antibody sequences from most species genomes (even if only partial assemblies are available).
Change the isotype or subtype of any antibody to alter the in vivo effector function, stability and aggregation profile of an antibody. Converting an IgG to an IgM can be used to increase avidity

Humanization
Royalty free antibody humanization service to identify a variant that retains activity and has preferential manufacturing criteria (e.g. high expression, low aggregation).

Antibody fragments
Convert an antibody into a fragment, such as a single chain Fv (scFv), Fab or F(ab)’2, followed by expression and purification at any scale.

Bispecific and multispecific antibodies
Bispecific/multispecific antibody service utilising a variety of formats.


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Antibody Purification

Price on request

Absolute Antibody offers transient mammalian expression and purification of your antibody at any scale from 1 microgram to 1 gram. Our proprietary high yielding serum-free mammalian production system - ABS293 is derived from HEK293 cells and allows to offer a service which is:

  • Rapid – from electronic sequence of antibody to purified protein in as little as 6 weeks. Even quicker for repeat batches where the antibody is already cloned into a vector.
  • High purity – no albumin or bovine IgG contamination
  • Low endotoxin – compatible with all in vitro or in vivo applications
  • Flexible – almost all species, IgG-subtypes and alternative isotypes and formats are available (see antibody enginering service for more information).

We also offer a guaranteed IgG expression service and a variant expression service


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Hybridoma Sequencing

Price on request

Next Generation Sequencing of Hybridomas (NGS)

Hybridoma sequencing is the sequencing of the cDNA encoding the variable heavy (VH) and variable light (VL) domains of your hybridoma cell line. Sequencing the antibody genes of your hybridoma offers many advantages including the following:

  • Security - your antibody can always be produced recombinantly even if your hybridoma line is lost
  • Humanization - once you know the VH and VL sequences you can proceed to humanisation if part of a therapeutic antibody project
  • Flexibility - convert your antibody to any species, isotype or format
  • Intellectual property - patent the sequences of your unique variable domains

Absolute Antibody offers a guaranteed antibody sequencing service.


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De Novo Antibody Sequencing

Price on request
Request a quote for more information about this service.

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Antibody Humanization

Price on request

We offer a royalty free antibody humanization service which aims to identify a variant that retains activity and has preferential manufacturing criteria (e.g. high expression, low aggregation).


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Antibody Fragment Production

Price on request
Request a quote for more information about this service.

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Therapeutic Monoclonal Antibody (mAb) Development

Price on request
Request a quote for more information about this service.

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Antibody Services

Price on request
Request a quote for more information about this service.

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Protein Services

Price on request
Request a quote for more information about this service.

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Michael Fiebig

Business Development Director
IW

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