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Abpro Bioresearch

Woburn, Massachusetts, US

Abpro Bioresearch provides early stage non-GLP preclinical studies to assess drug candidates during early product development process. We are flexible and responsive, providing customized studies to suit each study objectives. With our diverse expertise and comprehensive experience, we offer a range of animal models in rodents for pharmacology & toxicology studies as well as in vitro studies which can be stand alone or in support of in vivo studies.

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In vivo Drug Efficacy Testing
Price on request

Whether you are assessing small molecule drug candidate efficacy in a human xenograft tumor mouse model, or evaluation of immune-based therapies in a syngeneic mouse tumor model, Abpro BIoresearch provides you with the expertise in a wide variety of models and dosing routes and regimens to suit your needs. Efficacy as measured by... Show more »

Whether you are assessing small molecule drug candidate efficacy in a human xenograft tumor mouse model, or evaluation of immune-based therapies in a syngeneic mouse tumor model, Abpro BIoresearch provides you with the expertise in a wide variety of models and dosing routes and regimens to suit your needs. Efficacy as measured by tumor growth kinetics can be combined with pharmacokinetics, clinical pathology, histopathology and local/systemic immune function profiling in the following models:

  • Xenograft tumor models
  • Syngeneic mouse tumor models
  • PDX models
  • Custom models upon request
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Flow cytometry
xenograft
Colorectal cancer
Syngeneic tumor model
Orthotopic tumor xenograft model
Prostate Cancer
Breast Cancer
Lung Cancer
Ovarian Cancer
Gastric Cancer
Melanoma Skin Cancer
Pancreatic cancer
Liver cancer
bladder cancer
PDX
in vivo imaging
Preclinical Efficacy Studies
Price on request
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Mouse
Rat
Cancer
metabolic
xenograft
Syngeneic tumor model
Orthotopic tumor xenograft model
Autoimmune
In vivo Toxicity Testing
Price on request

Abpro offers a full range of in vivo non-GLP toxicology services in both mice and rats providing early assessment of drug candidate toxicity allowing for a more informed drug discovery direction and more confident decision-making. Examples of our toxicology study capabilities include:

Abpro offers a full range of in vivo non-GLP toxicology services in both mice and rats providing early assessment of drug candidate toxicity allowing for a more informed drug discovery direction and more confident decision-making. Examples of our toxicology study capabilities include:

  • Toxicokinetics
  • Maximum tolerated dose estimation (fixed or up and down dosing schedule)
  • Acute toxicity (up to 14 days)
  • Single or repeated dose
  • NOEL/NOAEL
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Repeated dose Toxicology 14, 28, 90 days
Toxicology
MTD
dose range finding
Single dose toxicology
Preclinical PK/PD Studies
in vivo Pharmacokinetics/Pharmacodynamics
Price on request

with noncompartmental and compartmental analysis

Abpro offers in vivo preclinical pharmacology services in both mouse and rat using a full range of dosing administration routes and regimens for both small molecules and biologics. Tissue and body fluid samples can either be shipped to the sponsor or undergo bioanalysis at Abpro.

with noncompartmental and compartmental analysis

Abpro offers in vivo preclinical pharmacology services in both mouse and rat using a full range of dosing administration routes and regimens for both small molecules and biologics. Tissue and body fluid samples can either be shipped to the sponsor or undergo bioanalysis at Abpro.

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PK/PD
in vivo PK
Human Tumor Xenograft Models
Price on request
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Brain Tumor models
Breast Tumor models
Colon Tumor models
Leukemia models
Liver cancer models
Lung cancer models
Lymphoma Tumor models
Melanoma Tumor models
Mesothelioma Tumor models
Multiple Myeloma Tumor models
Neuroblastoma models
Ovarian Cancer models
Pancreas Tumor models
Syngeneic (Allograft) Tumor Models
Price on request
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Breast Tumor models
Leukemia models
Lymphoma Tumor models
Melanoma Tumor models
Pancreas Tumor models
Colorectal models
Liver tumor models
Lung tumor models
Renal Tumor models
Sarcoma Tumor Models
Metabolic Disease Animal Models
Price on request

Choosing the most appropriate model for your metabolic disease research and drug development projects is crucial for proper efficacy assessment of therapeutic interventions. At Abpro, we can work with you to choose the most appropriate model for your disease area from a wide array of genetic or (diet or drug) induced disease... Show more »

Choosing the most appropriate model for your metabolic disease research and drug development projects is crucial for proper efficacy assessment of therapeutic interventions. At Abpro, we can work with you to choose the most appropriate model for your disease area from a wide array of genetic or (diet or drug) induced disease models. Examples include:

  • Type I and II diabetes models
  • Nutritional and genetic obesity models
  • Dyslipidemia
  • Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)
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Autoimmune Disease Animal Models
Price on request

With the wide range of rodent autoimmune and inflammatory models of human disease it can be confusing to decide which model is best for your particular drug development and research needs. Our immunology scientists have the knowledge and experience to help you design the most appropriate studies for your goals. We can provide you... Show more »

With the wide range of rodent autoimmune and inflammatory models of human disease it can be confusing to decide which model is best for your particular drug development and research needs. Our immunology scientists have the knowledge and experience to help you design the most appropriate studies for your goals. We can provide you a comprehensive qualitative and quantitative assessment of immune cell populations and functional readouts. Examples of our disease models include:

  • Systemic Lupus Erythematosus (SLE)
  • Multiple Sclerosis
  • Type 1 diabetes
  • Psoriasis
  • Inflammatory Bowel Disease
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In vitro Antibody-Drug Conjugate Toxicity Testing
Price on request
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
Price on request
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Custom Cell-Based Assays
Price on request

Abpro has a highly talented team of immunoassay scientists with extensive assay development experience. Our team has delivered high quality, functional monoclonal antibodies and corresponding assays to traditionally difficult targets (e.g., GPCRs, high homology proteins, idiotypes). Our expertise includes, but is not limited to:... Show more »

Abpro has a highly talented team of immunoassay scientists with extensive assay development experience. Our team has delivered high quality, functional monoclonal antibodies and corresponding assays to traditionally difficult targets (e.g., GPCRs, high homology proteins, idiotypes). Our expertise includes, but is not limited to: sandwich ELISAs for diagnostic kit development, competition, neutralizing, and blocking assays for drug screening and development.

In addition to assay development, we also have high throughput screening capabilities. Our platform leverages state-of-the-art automation to process and screen a huge volume of samples accurately and efficiently. Our screening capabilities include:

  • ELISA
  • Affinity Ranking (ForteBio Octet™)
  • Western Blots
  • Flow Cytometry
  • Immunoprecipitation
  • Dot Blot

Assay development and high throughput screening can be included as part of a custom antibody development project or offered as an independent service.

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Pharmacology & Toxicology
Price on request
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Biochemistry & Molecular Biology
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Drug Discovery & Development
Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Drug Potency and Efficacy Testing
Price on request

Drug Potency and Efficacy Testing Services

Drug Potency and Efficacy Testing Services

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Custom Mouse Models
Price on request

Oncology Animal Models Services - Xenograft, syngeneic, PDX
Also offer a wide array of genetic or induced disease models such as Type I and II diabetes models, inflammatory bowel disease

Oncology Animal Models Services - Xenograft, syngeneic, PDX
Also offer a wide array of genetic or induced disease models such as Type I and II diabetes models, inflammatory bowel disease

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Mouse
Rat
In vitro Toxicity Testing
Price on request

In vitro Toxicity Testing Services

In vitro Toxicity Testing Services

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Oncology Animal Models
Price on request

Oncology Animal Models Services

Oncology Animal Models Services

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Rodent Models
Price on request

Rodent Models Services

Rodent Models Services

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