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Abpro Labs

Woburn, Massachusetts, US

Abpro is a Massachusetts based biotechnology company. We are a global leader in therapeutic antibody discovery targeting cancer, auto immune and other diseases. Our mission is to bring innovation to the life sciences industry and ultimately improve living health. Our DiversImmune™ discovery platform has streamlined all aspects of the process to deliver antibodies at industry leading speeds against previously difficult targets. Our products and discovery services are used by leading academic labs and companies around the world for research purposes, such as diagnostics and therapeutics. We are currently collaborating with many pharmaceutical and biotech companies in the United States and China to co-develop bispecific antibodies using this platform.

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Drug Potency and Efficacy Testing
Price on request

Whether you are assessing small molecule drug candidate efficacy in a human xenograft tumor mouse model, or evaluation of immune-based therapies in a syngeneic mouse tumor model, Abpro provides you with the expertise in a wide variety of models and dosing routes and regimens to suit your needs. Efficacy as measured by tumor... Show more »

Whether you are assessing small molecule drug candidate efficacy in a human xenograft tumor mouse model, or evaluation of immune-based therapies in a syngeneic mouse tumor model, Abpro provides you with the expertise in a wide variety of models and dosing routes and regimens to suit your needs. Efficacy as measured by tumor growth kinetics can be combined with pharmacokinetics, clinical pathology, histopathology and local/systemic immune function profiling in the following models:

  • Xenograft tumor models
  • Syngeneic mouse tumor models (custom designed for your intended target)
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Metabolic Disease Animal Models
Price on request

Choosing the most appropriate model for your metabolic disease research and drug development projects is crucial for proper efficacy assessment of therapeutic interventions. At Abpro, we can work with you to choose the most appropriate model for your disease area from a wide array of genetic or (diet or drug) induced disease... Show more »

Choosing the most appropriate model for your metabolic disease research and drug development projects is crucial for proper efficacy assessment of therapeutic interventions. At Abpro, we can work with you to choose the most appropriate model for your disease area from a wide array of genetic or (diet or drug) induced disease models. Examples include:

  • Type I and II diabetes models
  • Nutritional and genetic obesity models
  • Dyslipidemia
  • Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)
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Small Animal Toxicology Studies
Price on request

Abpro offers a full range of in vivo non-GLP toxicology services in both mice and rats providing early assessment of drug candidate toxicity allowing for a more informed drug discovery direction and more confident decision-making. Examples of our toxicology study capabilities include:

Abpro offers a full range of in vivo non-GLP toxicology services in both mice and rats providing early assessment of drug candidate toxicity allowing for a more informed drug discovery direction and more confident decision-making. Examples of our toxicology study capabilities include:

  • Toxicokinetics
  • Maximum tolerated dose estimation (fixed or up and down dosing schedule)
  • Acute toxicity (up to 14 days)
  • Subacute toxicity
  • Chronic toxicity
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PK/PD Modeling
Pharmacokinetics/Pharmacodynamics Modeling
Price on request

with noncompartmental and compartmental analysis

Abpro offers in vivo preclinical pharmacology services in both mouse and rat using a full range of dosing administration routes and regimens for both small molecules and biologics. Tissue and body fluid samples can either be shipped to the sponsor or undergo bioanalysis at Abpro.

with noncompartmental and compartmental analysis

Abpro offers in vivo preclinical pharmacology services in both mouse and rat using a full range of dosing administration routes and regimens for both small molecules and biologics. Tissue and body fluid samples can either be shipped to the sponsor or undergo bioanalysis at Abpro.

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Autoimmune Disease Animal Models
Price on request

With the wide range of rodent autoimmune and inflammatory models of human disease it can be confusing to decide which model is best for your particular drug development and research needs. Our immunology scientists have the knowledge and experience to help you design the most appropriate studies for your goals. We can provide you... Show more »

With the wide range of rodent autoimmune and inflammatory models of human disease it can be confusing to decide which model is best for your particular drug development and research needs. Our immunology scientists have the knowledge and experience to help you design the most appropriate studies for your goals. We can provide you a comprehensive qualitative and quantitative assessment of immune cell populations and functional readouts. Examples of our disease models include:

  • Systemic Lupus Erythematosus (SLE)
  • Multiple Sclerosis
  • Type 1 diabetes
  • Psoriasis
  • Inflammatory Bowel Disease
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Custom Cell-Based Assays
Price on request

Abpro has a highly talented team of immunoassay scientists with extensive assay development experience. Our team has delivered high quality, functional monoclonal antibodies and corresponding assays to traditionally difficult targets (e.g., GPCRs, high homology proteins, idiotypes). Our expertise includes, but is not limited to:... Show more »

Abpro has a highly talented team of immunoassay scientists with extensive assay development experience. Our team has delivered high quality, functional monoclonal antibodies and corresponding assays to traditionally difficult targets (e.g., GPCRs, high homology proteins, idiotypes). Our expertise includes, but is not limited to: sandwich ELISAs for diagnostic kit development, competition, neutralizing, and blocking assays for drug screening and development.

In addition to assay development, we also have high throughput screening capabilities. Our platform leverages state-of-the-art automation to process and screen a huge volume of samples accurately and efficiently. Our screening capabilities include:

  • ELISA
  • Affinity Ranking (ForteBio Octet™)
  • Western Blots
  • Flow Cytometry
  • Immunoprecipitation
  • Dot Blot

Assay development and high throughput screening can be included as part of a custom antibody development project or offered as an independent service.

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Therapeutic Monoclonal Antibody (mAb) Development
Price on request

We are a global leader in therapeutic antibody discovery targeting cancer, auto immune and other diseases. Our mission is to bring innovation to the life sciences industry and ultimately improve living health. Our DiversImmune™ discovery platform has streamlined all aspects of the process to deliver antibodies at industry leading... Show more »

We are a global leader in therapeutic antibody discovery targeting cancer, auto immune and other diseases. Our mission is to bring innovation to the life sciences industry and ultimately improve living health. Our DiversImmune™ discovery platform has streamlined all aspects of the process to deliver antibodies at industry leading speeds against previously difficult targets. Our products and discovery services are used by leading academic labs and companies around the world for research purposes, such as diagnostics and therapeutics. We welcome collaboration with partners to co-develop therapeutic bispecific antibodies using this platform.

« Show less
Animal Models and Studies
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Cell-Based Assays
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Animal Models of Disease
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Protein Services
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Biology
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Toxicology
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In vivo Toxicity Testing
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Metabolic Animal Models
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Immunology Animal Models
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Pharmacology & Toxicology
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Antibody Services
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ADME and DMPK Studies
Drug Metabolism and Pharmacokinetics
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Specialized Cell-Based Assays
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Biochemistry & Molecular Biology
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