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Abby and Howard P. Milstein Chemistry Core Facility

4 Orders Completed
New York, New York, US

About Abby and Howard P. Milstein Chemistry Core Facility

The Abby and Howard P. Milstein Chemistry Core Facility (MCCF) was established in 2006 through the generosity of Weill Cornell Overseer Howard P. Milstein. Though primarily designed to assist with synthetic chemistry, our expertise and equipment allows us to provide essential analytical services as well. Major... Show more »

The Abby and Howard P. Milstein Chemistry Core Facility (MCCF) was established in 2006 through the generosity of Weill Cornell Overseer Howard P. Milstein. Though primarily designed to assist with synthetic chemistry, our expertise and equipment allows us to provide essential analytical services as well. Major equipment includes UPLC/MS, with mass detection up to 3000 amu, preparative HPLC/MS, preparative HPLC, GC/MS, IR, automated microwave synthesizer, and automated chromatography instrumentation. The recent acquisition of an Agilent RapidFire LC/MS system greatly expands our analytical capabilities. For example, we are now able to offer fragmentation analysis of analytes using the triple quadrupole mass spectrometer.

Our work is accomplished through the design and execution of efficient and economical synthesis of chemicals that are either not readily available through commercial vendors, or are prohibitively expensive. Such compounds may be known in the literature, or entirely novel, and can be generated in virtually any quantity desired, from sub-milligram quantities to tens of grams, using equipment currently within the lab. Each molecule generated is fully characterized by modern analytical techniques.

Synthetic projects generally fall within two subcategories:

• synthesis of a single compound that is known in the literature, or obtained from a chemical screen
• synthesis of compounds with unknown utility, but are predicted to have desirable properties

Analytical projects also generally fall within three subcategories:

• identification of unknown and/or known molecular entities
• evaluation of extracts from cellular assays
• analysis of biological extracts, serum, or plasma

The Milstein Chemistry Core Facility is supported by the Howard and Abby Milstein Foundation through its medical philanthropy. To learn more about this charity, please visit the Howard and Abby Milstein Foundation website.

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Our Services (11)


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Chemical Synthesis

Price on request

• Chemical synthesis of compounds that are not readily available, or are prohibitively expensive from external vendors

• Synthesis of assay development tools and reagents including: fluorescently labeled compounds; affinity labeled compounds; cross linker-tethered molecules; labeled (13C, 2H, 15N) and radiolabeled (3H, 14C,... Show more »

• Chemical synthesis of compounds that are not readily available, or are prohibitively expensive from external vendors

• Synthesis of assay development tools and reagents including: fluorescently labeled compounds; affinity labeled compounds; cross linker-tethered molecules; labeled (13C, 2H, 15N) and radiolabeled (3H, 14C, 32P, 125I, etc.) compounds for preclinical and clinical pharmacological studies

• Synthesis of compounds in quantities that allow for in vitro and in vivo assays, and followup assays when warranted

• Large-scale chemical synthesis of compounds with demonstrated biological activity in primary assays, to provide material for further investigation

• Confirmatory synthesis of compounds identified via high-throughput screening

• Consultation on experimental design and/or procedures, the commercial availability of individual chemical compounds and/or reagents, and the feasibility of chemical structures

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Chemical Analysis

Price on request

• Structure determination of unknown molecular entities

• Detailed chemical analysis of reaction mixtures, cell extracts, and bioassays

• Structure determination of unknown molecular entities

• Detailed chemical analysis of reaction mixtures, cell extracts, and bioassays

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Molecular Modeling

Price on request

• Molecular modeling and in silico screening using a variety of computational tools, including the Schrödinger software suite and Chemical Computing Group's Molecular Operating Environment (MOE)

• Molecular modeling and in silico screening using a variety of computational tools, including the Schrödinger software suite and Chemical Computing Group's Molecular Operating Environment (MOE)

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QSAR Studies

Quantitative Structure-Activity Relationship Studies
Price on request

• Structure-activity relationship (SAR) studies on validated pharmacophores in order to optimize targeting, specificity, and bioavailability, while minimizing toxicity

• Structure-activity relationship (SAR) studies on validated pharmacophores in order to optimize targeting, specificity, and bioavailability, while minimizing toxicity

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Radiolabeling/Radiosynthesis

Price on request

• Synthesis of assay development tools and reagents including: fluorescently labeled compounds; affinity labeled compounds; cross linker-tethered molecules; labeled (13C, 2H, 15N) and radiolabeled (3H, 14C, 32P, 125I, etc.) compounds for preclinical and clinical pharmacological studies

• Synthesis of assay development tools and reagents including: fluorescently labeled compounds; affinity labeled compounds; cross linker-tethered molecules; labeled (13C, 2H, 15N) and radiolabeled (3H, 14C, 32P, 125I, etc.) compounds for preclinical and clinical pharmacological studies

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Computational Modeling

Price on request
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Synthetic Chemistry

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Computational Chemistry

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Analytical Chemistry Services

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Radiochemistry

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Chemistry and Materials

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JW

J David Warren

Associate Research Professor

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