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AbBioSci

Seattle, Washington, US

AbBioSci is a privately held US Biotech Company that is focused on the production, detection, and characterization of Multi-Format Antibodies (MFAbs) for research, diagnostic, and therapeutic use. The MFAbs basically includes Polyclonal Antibodies (pAb), Monoclonal Antibodies (mAb) and Recombinant Antibodies (rAb) and Antibody Engineering Fragments (Ab-Eng). Our MFAbs technologies incorporate traditional and proprietary serological and genetic engineering approaches to produce antibodies formatted to exhibit defined antigen binding specificities and immunological properties.

AbBioSci’S mission is to help life science customers reach their goals, in which they could apply the right format antibody to research projects and product developments. We even combine three format antibodies with customers’ research goals and interesting targets to maximally create potential diagnostic and therapeutic antibodies.

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Animal Immunization for Antibody Production
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Rabbit
Guinea pig
Goat
Chicken
Mouse
Rat
Antibody Fragment Production
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Recombinant antibody production
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Recombinant antibodies (rAb) are important tools for biomedical research and they are increasingly being used as clinical diagnostic and therapeutic reagents. Currently, antibody genes can be easily and quickly cloned, genetically manipulated, and expressed to produce rAbs to any interesting targets because DNA recombinant... Show more »

Recombinant antibodies (rAb) are important tools for biomedical research and they are increasingly being used as clinical diagnostic and therapeutic reagents. Currently, antibody genes can be easily and quickly cloned, genetically manipulated, and expressed to produce rAbs to any interesting targets because DNA recombinant technology becomes mature and antibody genes, function and structure are more clear than any other stage.

Straight question you may ask is why do I need to make an rAb. Simple answer is that you could obtain antibodies and its genes simultaneously and quickly. rAb’s open ways to build genetic links between antibodies and genes. You are not restricted by using antibody only without knowing anything about its gene. With its genes, you can do a lot of things. A successful demonstration for example in the field was to make a GFP-fusion antibody that combined GFP fluorescence with binding characteristics of antibodies by recombinant antibody technology.

Three platforms are established and applied to produce recombinant antibodies (rAb) to a variety of targets:

  1. rAb selection from random library;
  2. rAb selection from target-specific library;
  3. rAb selection from activated cells.

We provide customer’s rAb with very flexible options and packages as each platform focuses.

Unique Feature with flexible options:

  • rAb from random library in Vitro
  • rAb from target-specific library in Vivo/Vitro
  • rAb from hybridoma
  • rAb from immunized animal
  • rAb from available gene or sequence
  • rAb from sorted and identified cells
  • Combination: pAb to rAb to whole Ig
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Antibody Engineering Services
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Antibody Engineering (Ab-Eng) is the efficient way to create a functional antibody with a suitable size by using DNA recombinant technology. As long as an antibody gene becomes available, the gene can be purposely engineered or modified in vitro to obtain a desirable antibody with biological activity. Mainly, that is to reformat... Show more »

Antibody Engineering (Ab-Eng) is the efficient way to create a functional antibody with a suitable size by using DNA recombinant technology. As long as an antibody gene becomes available, the gene can be purposely engineered or modified in vitro to obtain a desirable antibody with biological activity. Mainly, that is to reformat antibody fragments (Fc-scFv, Bis-Ab and so on) by using characterized-well rAb, such as Fab, scFv and etc. These include antigen binding region discovery, fusion molecules with dual or multiple functions, humanization, antibody fragment to full immunoglobulin. Antibody animation structurally demonstrates each part derived from the antibody.

Unique Feature with flexible options:

  • Improve rAb function
  • Create multiple functional molecules
  • Multiple antibody fragments for choice
  • Antibody comes with its gene
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Polyclonal Antibody Production
Price on request

Mostly, its called an antiserum or immunized serum. It can be produced in different species of animals, including mouse, rat, guinea pig, rabbit, chicken, goat and etc. Because of generating sources, it mainly consists of IgG or IgY. pAb recognizes multiple epitopes on antigen since immunized animal. Our outline, features and... Show more »

Mostly, its called an antiserum or immunized serum. It can be produced in different species of animals, including mouse, rat, guinea pig, rabbit, chicken, goat and etc. Because of generating sources, it mainly consists of IgG or IgY. pAb recognizes multiple epitopes on antigen since immunized animal. Our outline, features and followings will quickly direct you with a guide of what services we provide.

Unique Features with flexible options:

  • From pAb to mAb or rAb or both
  • Combining pAb with mAb and rAb
  • Multiple hosts for choice
  • Antibody with/without gene
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Monoclonal Antibody (mAb) Production
Price on request

Monoclonal antibody (mAb) is made specifically to recognize a single epitope on an antigen because the mAb come from only one type of cell, the hybridoma cell. So it becomes an important reagents utilized in a variety of experimental techniques in many fields of biomedical research. More importantly, they are potentially more... Show more »

Monoclonal antibody (mAb) is made specifically to recognize a single epitope on an antigen because the mAb come from only one type of cell, the hybridoma cell. So it becomes an important reagents utilized in a variety of experimental techniques in many fields of biomedical research. More importantly, they are potentially more effective than conventional drugs in fighting diseases. For this reason, it has been widely applied to develop therapeutic reagents.
Both rat and mouse mAbs are available for you to choose from . Our unique service can be present by three formats of combination, conversion and modification, pAb to mAb to rAb. That is to give you a flexible option to have three format antibodies to match your needs. It is shown in the following service packages and options.

Unique Feature with flexible options:

  • mAb from fusion in mice or rat
  • Combining option 1: tested pAb, then mAb
  • Combining option 2: validated mAb, then rAb
  • mAb gene from hybridoma
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Antibody Modification
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Antibody Screening
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Service Cat# rAb-PD-11
Deliverable Package
-Sample from positive clones
-Purified antibody from one desired clone
-Antigen if peptide
-Antibody Gene profile
-With free secondary antibody
-Full service report

Service Cat# rAb-PD-11
Deliverable Package
-Sample from positive clones
-Purified antibody from one desired clone
-Antigen if peptide
-Antibody Gene profile
-With free secondary antibody
-Full service report

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Antibody Affinity Maturation
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Epitope Mapping
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Define the exact binding region of a well-characterized antibody to an antigen

Define the exact binding region of a well-characterized antibody to an antigen

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Antigen design
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Choose and Prepare correct Antigen

Choose and Prepare correct Antigen

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Antibody Characterization
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In in vitro and in vivo.

In in vitro and in vivo.

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Immunoassay Services
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Screen the two best antibody binders to a well-characterized target by SPR-based competition and other immunoassays

Screen the two best antibody binders to a well-characterized target by SPR-based competition and other immunoassays

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Antibody Conjugation
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Immunoassays
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Protein Services
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Biology
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Pharmacology & Toxicology
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Therapeutic Monoclonal Antibody (mAb) Development
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Antibody Services
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Biochemistry & Molecular Biology
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