Ab Studio Inc.

1. Detailed sequence analysis and 3D structure modeling

• Identification of the best human germline sequence templates, grafting the rodent or rabbit antibody CDR regions into the human antibody frameworks
• Identifying back-mutations and remove “hot spots” with developability issues
• High throughput lead selection and evaluation
• Efficient lead preparation for research purpose in house (up to 20mg), CMC level protein preparation at the facility of our CMC partner

1. Monoclonal Antibody discovery service: hybridoma and phage display

• Antigen design via bioinformatics and computer aided design
• Antibody development via hybridoma and/or phage display technology
• Screening mAb clones for high affinity, high expression, good efficacy and good developability
• Bispecific antibody discovery service
  • Apply “knob into hole” plus common light chain technology for bispecific antibody development
  • Use Ab Studio’s unique methodology to screen common light chain
  • Apply computer aided design to engineer the two arms of a bi-specifc antibody for better purification efficacy
• Internalization antibody discovery service

1. Detailed sequence analysis and 3D structure modeling

• Identification of the best human germline sequence templates, grafting the rodent or rabbit antibody CDR regions into the human antibody frameworks
• Identifying back-mutations and remove “hot spots” with developability issues
• High throughput lead selection and evaluation
• Efficient lead preparation for research purpose in house (up to 20mg), CMC level protein preparation at the facility of our CMC partner

We collaborate with our partner Data-revive for IND filing

• We will discuss with specialists at Data-revive for the need of IND filing during the whole process of preclinical stage therapeutic antibody development
• We will write antibody discovery, lead selection, antibody humanization and optimization report to support our clients to file IND

Antibody Development Service (CMC)

1. We partner with Mab-Venture Biopharma to provide our clients with high quality CMC services.

• We can also work with CMC facilities chosen by our clients for lead therapeutic antibody manufacture protcol design and process trouble shooting