Ab Studio Inc.

1. Detailed sequence analysis and 3D structure modeling
   
2. Identification of the best human germline sequence templates, grafting the rodent or rabbit antibody CDR regions into the human antibody frameworks
   
3. Identifying back-mutations and remove “hot spots” with developability issues
   
4. High throughput lead selection and evaluation
   
5. Efficient lead preparation for research purpose in house (up to 20mg), CMC level protein preparation at the facility of our CMC partner

1. Monoclonal Antibody discovery service: hybridoma and phage display
   
   • Antigen design via bioinformatics and computer aided design
     
   • Antibody development via hybridoma and/or phage display technology
     
   • Screening mAb clones for high affinity, high expression, good efficacy and good developability
     
2. Bispecific antibody discovery service
   
   • Apply “knob into hole” plus common light chain technology for bispecific antibody development
     
   • Use Ab Studio’s unique methodology to screen common light chain
     
   • Apply computer aided design to engineer the two arms of a bi-specifc antibody for better purification efficacy
     
3. Internalization antibody discovery service
   

1. Detailed sequence analysis and 3D structure modeling
   
2. Identification of the best human germline sequence templates, grafting the rodent or rabbit antibody CDR regions into the human antibody frameworks
   
3. Identifying back-mutations and remove “hot spots” with developability issues
   
4. High throughput lead selection and evaluation
   
5. Efficient lead preparation for research purpose in house (up to 20mg), CMC level protein preparation at the facility of our CMC partner

We collaborate with our partner Data-revive for IND filing

• We will discuss with specialists at Data-revive for the need of IND filing during the whole process of preclinical stage therapeutic antibody development
  
• We will write antibody discovery, lead selection, antibody humanization and optimization report to support our clients to file IND

Antibody Development Service (CMC)

1. We partner with Mab-Venture Biopharma to provide our clients with high quality CMC services.
   
2. We can also work with CMC facilities chosen by our clients for lead therapeutic antibody manufacture protcol design and process trouble shooting