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2bind GmbH

Regensburg, DE

The 2bind GmbH is a provider of biophysical analytical services. Our main focus is on early drug discovery phases. Our mission is to assist our customers and collaboration partners with our biophysical assays. In addition, we offer assays to characterize protein stability and aggregation tendency.

Our team of experts can help in HTS assays to identify potent binding partners of a drug target. In addition, our assays allow to characterize a lead candidate in terms of basic binding parameters such as binding affinity, kinetics and thermodynamics. Last but not least, we can assist with assays to understand the MOA of a specific drug.

Our assays are based on different technologies:

  1. MicroScale Thermophoresis
    Our MicroScale Thermophoresis (MST) assays help to study the interaction between target protein and drug candidate(s). We offer a broad assay range from library screens, validation assays, competition... Show more »

The 2bind GmbH is a provider of biophysical analytical services. Our main focus is on early drug discovery phases. Our mission is to assist our customers and collaboration partners with our biophysical assays. In addition, we offer assays to characterize protein stability and aggregation tendency.

Our team of experts can help in HTS assays to identify potent binding partners of a drug target. In addition, our assays allow to characterize a lead candidate in terms of basic binding parameters such as binding affinity, kinetics and thermodynamics. Last but not least, we can assist with assays to understand the MOA of a specific drug.

Our assays are based on different technologies:

  1. MicroScale Thermophoresis
    Our MicroScale Thermophoresis (MST) assays help to study the interaction between target protein and drug candidate(s). We offer a broad assay range from library screens, validation assays, competition assays and so on. Basic binding parameters such as affinity, stoichiometry and thermodynamics can be determined. MST is fast, precise, offers free choice of buffer and low sample consumption.

  2. Biolayer Interferometry
    BLI is a surface based method, allowing to study kinetics of molecular interactions

  3. Isothermal titration calorimetry
    ITC is an in-solution method, enabling to study thermodynamics of molecular interactions without modification of the interaction partners.

  4. nanoDSF assay
    Our nanoDSF services offer information on the folding and the stability of the target protein. Buffer or detergent screens are used to determine optimal conditions for the target protein in terms of stability. Furthermore, quality controls as well as ligand screens can be performed using this innovative technology. nanoDSF works without modification of the target protein, with free choice of buffer and low sample consumption

Our worldwide customers are mainly biotech and pharma companies as well as scientists from universities. Their main interest field are drug development, antibody discovery, epigenetics and aptamer development.

Up to date we have finished over 350 projects with 6 of the top 10 pharma companies, more than 60 biotech companies and over 25 universities.

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2bind GmbH has not listed any services.

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Microscale Thermophoresis
Price on request

2bind offers label-free and fluorescence based MST assays. These include binding assays, stoichiometry assays, competition assays, assays with multiple binding partners, binding site mapping assays, stability assays and buffer optimization assays.

Dependent on the specific project the amount of required sample may differ as... Show more »

2bind offers label-free and fluorescence based MST assays. These include binding assays, stoichiometry assays, competition assays, assays with multiple binding partners, binding site mapping assays, stability assays and buffer optimization assays.

Dependent on the specific project the amount of required sample may differ as well as the turnover. MST measurements from 400 USD.

Samples should be shipped on dry ice.

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NanoDSF
Price on request

We offer nanoDSF assays to customers. Our assays based on the Prometheus NT48 system, enable to study thermal stability (melting temperature; Tm), Tm onset and aggregation behavior (T agg) of proteins. Main appication areas are buffer screening, small molecule ligand screening, quality controls, batch comparison, biosimilar studies, antibody characterization.

We offer nanoDSF assays to customers. Our assays based on the Prometheus NT48 system, enable to study thermal stability (melting temperature; Tm), Tm onset and aggregation behavior (T agg) of proteins. Main appication areas are buffer screening, small molecule ligand screening, quality controls, batch comparison, biosimilar studies, antibody characterization.

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Isothermal Titration Calorimetry (ITC)
Price on request

We offer Isothermal Titration Calorimetry (ITC) to our customers. The ITC assays enable to study thermodynamics of molecular interactions. Main application areas are aptamer characteriaztion and drug discovery.

We offer Isothermal Titration Calorimetry (ITC) to our customers. The ITC assays enable to study thermodynamics of molecular interactions. Main application areas are aptamer characteriaztion and drug discovery.

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Biolayer Interferometry
Price on request

We offer Biolayer Interferometry assay to customers interested in binding kinetics of their molecular interactions. Main application areas are characterization of antibody-antigen interactions and protein-drug interactions.

We offer Biolayer Interferometry assay to customers interested in binding kinetics of their molecular interactions. Main application areas are characterization of antibody-antigen interactions and protein-drug interactions.

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Calorimetry
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Interferometry
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Imaging & Spectroscopy
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Physical Analysis Methods
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Thermal Analysis Services
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Chemistry and Materials
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Engineering
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Analytical Chemistry Services
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2018-03-26 15:24:32 -1000

Net Promoter Score of 9 received for Microscale Thermophoresis.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 8.

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