High-throughput gene expression profiling... | Science Exchange

High-throughput (HT) RNA-seq technologies are accelerating the transcriptome research and reshaping how we discover drugs, playing a pivotal role in decision-making across key stages of the drug discovery pipeline—including target identification and validation, mechanism-of-action profiling, biomarker discovery, and toxicogenomics (1). Its ability to generate rich, unbiased transcriptomic data enables effective compound triage and lead prioritization. 

Admera Health is excited to offer an end-to-end solution for your research, starting from cell culture and compound dispensing using the Echo liquid handler, followed by automated RNA purification with the BioEcho purification system. Our streamlined workflow supports flexible RNA-seq assay formats and is backed by customized data analysis and experienced project support. Our industry-leading turnaround time will keep your research moving efficiently from sample to discovery. 

While many clients are satisfied with gene expression profiling directly from cell lysates, extracted RNA samples often yield higher gene coverage. Our BioEcho purification system supports this by providing rapid, high-throughput RNA isolation. Depending on your research goals, we offer both 3′ Tag-seq, ideal for cost-effective differential gene expression analysis, and full-length mRNA-seq for deeper insights into splicing events, isoforms, and transcript variants. We support various established techniques, including Smart-seq 3', Quantseq Pool, DRUG-Seq, and BRB-Seq. These off-the-shelf products help us to achieve highly reproducible results with strong QA/QC metrics.

Explore the technology features

Single cell RNA-Seq and spatial transcriptomics services 

Single-cell transcriptomics provides an unparalleled level of resolution by enabling gene expression analysis at the individual cell level-an essential tool for advancing personalized medicine (2). As these technologies continue to evolve, Admera Health moves beyond standard platforms. Admera Health is proud to be certified service providers for leading technologies with 10x Genomics, Parse, and Takara. In addition to these leading technologies, we offer access to multiple systems including Scale Bio and Illumina and provide expert guidance to help you in selecting the optimal library preparation method for your specific needs.

Understand single-cell technologies and their features 

Admera Health is also a proud certified service provider for spatial transcriptomic technologies utilizing Visium HD and Stereo-seq, two cutting-edge platforms that empower scientists to unlock the full potential of spatial biology. Mapping gene expression to precise tissue locations adds further context to single cell data and enables a comprehensive view of biology-bridging molecular data with tissue structure to reveal deeper insight into health and disease (3, 4).

These powerful tools are particularly valuable for projects involving diverse and challenging sample types, including FFPE and fixed tissues, as well as complex organs like brain, heart, kidney, liver, lung, and pancreas. Admera Health possesses extensive experience in handling these demanding samples, having successfully executed a wide array of single-cell and spatial transcriptomics projects. Our deep expertise, honed through hands-on work with these various tissue types, ensures meticulous tissue processing and robust fixed-RNA profiling. Recognizing the critical role of sample preparation, Admera Health provides tailored support across a wide range of tissue types, storage conditions, and preservation methods, guaranteeing optimal sample integrity and maximizing data output for your research endeavors.

See real spatial transcriptomics results from Admera Health 

Figure 1: Spatial transcriptomics data visualization using Stereo-seq on fresh frozen mouse brain sample.

Figure 2: Spatial transcriptomics data visualization using Stereo-seq on fresh frozen mouse spinal cord sample.

Figure 3: Spatial transcriptomics data visualization using Stereo-seq on FFPE mouse head sample.  

Figure 4: Spatial transcriptomics data visualization using 10x Genomics Visium HD on fresh frozen human pancreatic cancer sample.  

For more information on spatial transcriptomics at Admera Health, visit www.admerahealth.com/spatial-transcriptomics  

Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics are transforming translational research by offering unprecedented resolution into cellular behavior and tissue architecture (5, 6). With a proven track record in FFPE handling and fixed-RNA profiling, Admera Health is well-equipped to seamlessly integrate single cell genomics into biomarker discovery. Our team brings deep expertise in navigating the unique challenges of working with clinical samples, including limited tissue availability and variable quality from archived slides. As a CLIA and CCP certified provider, we uphold rigorous regulatory standards to ensure exceptional accuracy, reproducibility, and reliability across translational research and clinical applications.